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Autor:
Michael M. Murray, Michael E. Kopach, Shujauddin M. Changi, Bernard McGarvey, Wei-Ming Sun, Sze-Wing Wong, Richard W. Shields, Willis V Bell, Martin D. Johnson, Tim M. Braden, Gordon Flanagan, Richard D. Spencer
Publikováno v:
Organic Process Research & Development. 20:540-550
This paper presents a case study in establishing the operation space of a Grignard reaction in a continuous stirred tank reactor (CSTR). The operation space is the multivariate space with the boundary defined by the proven acceptable range of every C