Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gordon F. Reidy"'
Publikováno v:
Biochemical Pharmacology. 44:815-818
The present study was undertaken to ascertain developmental profiles of microsomal epoxide hydrolase (mEH) and cytosolic epoxide hydrolase (cEH) enzyme activities in rat liver. During development, mEH activity reached an optimum by 6 weeks of age (63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99add64cbee7266241d835b4f44ad9d
https://doi.org/10.1016/0006-2952(92)90420-n
https://doi.org/10.1016/0006-2952(92)90420-n
Autor:
Gordon F. Reidy, Michael Murray
Publikováno v:
Biochemical and Biophysical Research Communications. 166:772-779
Removal of the orphenadrine metabolite from its complex with rat liver P-450 IIB1 is associated with a discrepancy in the reactivation of IIB1 activity. Two possible explanations are that either (1) NADPH-P-450-reductase is inaccessible to the restor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a0111ad3ff7a11de87fa6e4e30ad77
https://doi.org/10.1016/0006-291x(90)90876-o
https://doi.org/10.1016/0006-291x(90)90876-o
Publikováno v:
Biochemical Pharmacology. 37:4177-4181
Propiconazole, a foliar fungicide used for agricultural purposes was studied for its effects on the hepatic xenobiotic biotransformation in the rat. Rats were given an intraperitoneal injection of 0.1, 1, 10 or 100 mg/kg in corn oil for seven consecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff45acb72a01ff35a09c81002afd73c5
https://doi.org/10.1016/0006-2952(88)90113-x
https://doi.org/10.1016/0006-2952(88)90113-x
Autor:
Gordon F. Reidy, Michael Murray
Publikováno v:
Biochemical Pharmacology. 38:195-199
The in vitro inhibition of the cytochrome P-450 (P-450) isozyme specific positional hydroxylation of androst-4-ene-3,17-dione (androstenedione) by the alkylamino containing compounds trans -and cis -tamoxifen, 4-hydroxytamoxifen, N -desmethyltamoxife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eda9b6634eaa68db150299666ebe4a1
https://doi.org/10.1016/0006-2952(89)90168-8
https://doi.org/10.1016/0006-2952(89)90168-8
Autor:
Gordon F. Reidy, Michael Murray
Publikováno v:
Biochemical Pharmacology. 38:4359-4365
The phenothiazine tranquilizer thioridazine has been associated with drug interactions in man. This study investigated the capacity of the drug to inhibit hepatic drug oxidations mediated by cytochromes P-450 (P-450) in microsomes in vitro. Thioridaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a95b91c909d226c8a757dc7e807e12a
https://doi.org/10.1016/0006-2952(89)90643-6
https://doi.org/10.1016/0006-2952(89)90643-6
Publikováno v:
Biochemical pharmacology. 37(6)
Microsomes from male rats treated with picloram (100 mg/kg/day) for 7 days showed a 48% decrease in 16 alpha-hydroxylase activity when incubated with (4-14C) androstenedione. These data are consistent with the assertion that picloram decreases the ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6179078064550df18d28c6e9ad164ac
https://pubmed.ncbi.nlm.nih.gov/3355579
https://pubmed.ncbi.nlm.nih.gov/3355579
Publikováno v:
Archives of environmental contamination and toxicology. 18(6)
Ofurace, oxadixyl, and alachlor were studied for their effect on hepatic xenobiotic biotransformation in male rats by dosing i.p. with 1 or 100 mg/kg of chemical for 7 days. Ofurace decreased ethoxyresorufin-O-deethylase and aniline p-hydroxylase act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72bf0c72fa448323f96d3b82c58626e
https://pubmed.ncbi.nlm.nih.gov/2619326
https://pubmed.ncbi.nlm.nih.gov/2619326