Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Gordon E. Willick"'
Publikováno v:
Calcified Tissue International. 87:263-272
Many patients with symptomatic bone metastases receive radiation therapy, even though radiation is known to have potential adverse effects on bone. We hypothesized that the concurrent use of a bisphosphonate drug (zoledronic acid, ZA) or a combinatio
Autor:
Susanne MacLean, Jon P. Durkin, Ray H. Rixon, R. J. Isaacs, Wing L. Sung, Witold Neugebauer, V. Ross, Balu Chakravarthy, James F. Whitfield, Gordon E. Willick, Lyne Gagnon
Publikováno v:
Journal of Bone and Mineral Research. 9:1179-1189
PTH is regarded conventionally as a catabolic hormone that stimulates osteoclastic resorption of bone. However, it has been known since 1932 that intermittent pulses of PTH stimulate bone formation in animals and humans. PTH independently activates t
Publikováno v:
International Journal of Peptide and Protein Research. 43:555-562
Five analogues of human parathyroid hormone (hPTH-(20-34)-NH2, I; cyclo[Lys26-Asp30]-hPTH-(20-34)-NH2, II; cyclo[Glu22-Lys26]-hPTH-(20-34)-NH2, III; cyclo[Lys27-Asp30]- hPTH-(20-34)-NH2, IV; and [Leu27]-hPTH-(20-34)-NH2 V) were tested for their abili
Autor:
Ryszard Brzezinski, Barbier Jean-Rene, Ross E. Williams, Gordon E. Willick, Witold Neugebauer
Publikováno v:
Scopus-Elsevier
The use of chitin as a support for solid-phase peptide synthesis is described and illustrated by synthesis of four peptides, varying in length from 10 to 29 residues. Syntheses were performed in a continuous-flow peptide synthesizer, using Fmoc chemi
Autor:
James F. Whitfield, Thomas Dean, Thomas J. Gardella, Gordon E. Willick, Susanne MacLean, Barbier Jean-Rene, Zhanna Potetinova
Publikováno v:
Journal of Biological Chemistry. 280:23771-23777
We have used backbone N-methylations of parathyroid hormone (PTH) to study the role of these NH groups in the C-terminal amphiphilic α-helix of PTH (1–31) in binding to and activating the PTH receptor (P1R). The circular dichroism (CD) spectra ind
Publikováno v:
Calcified Tissue International. 74:351-356
The influence of intermittent hPTH(1-34)NH2, hPTH(1-31)NH2, and monocyclic [Leu27]cyclo (Glu22-Lys26)hPTH(1-31)NH2 treatment on callus formation, mechanical strength, and callus tissue mechanical quality of tibial fractures in rats was investigated a
Publikováno v:
Biochemistry. 40:8955-8961
Arg-20 is one of two residues conserved in all peptides known to activate the parathyroid hormone (PTH) receptor. Previous studies have failed to find any naturally encoded analogues of residue 20 that had any adenylyl cyclase (AC) stimulating activi
Publikováno v:
Current Pharmaceutical Design. 7:671-687
Osteoporosis is a disease characterised by low bone mass, structural deterioration of bone and increased risk of fracture. The prevalence, and cost, of osteoporosis is increasing dramatically with our ageing population and the World Health Organizati
Autor:
Gordon E. Willick, S. MacLean, James F. Whitfield, V. Ross, Barbier Jean-Rene, R. J. Isaacs, Paul Morley, Troels T. Andreassen
Publikováno v:
Calcified Tissue International. 68:95-101
The [Leu27]cyclo(Glu22-Lys26)-hPTH-(1-31)NH2 lactam is a stronger stimulator of adenylyl cyclase activity and a better stimulator of trabecular bone in the ovariectomized (OVX) rat model of osteopenia than hPTH-(1-31)NH2. This enhanced activity is du
Publikováno v:
Biochemistry. 39:14522-14530
Parathyroid hormone (PTH) has a helix-bend-helix structure in solution. Part of the C-terminal helix, residues 21-31, is amphiphilic and forms a critical receptor-binding region. Stabilization of this alpha-helix by lactam formation between residues