Výsledky vyhledávání - "Gordon D. Strachan"

E2F4 expression patterns in SIV encephalitis

Autor: Elisabeth M. Chalovich, Linda L. Otis, Kelly L. Jordan-Sciutto, Kathleen L. Morgan, Gordon D. Strachan

Publikováno v: Neuroscience Letters. 382:259-264

The E2F1 transcriptional regulator has been shown to exhibit altered expression and localization in HIVE and SIVE. However, other E2F family members are expressed in mature neurons and participate in neuronal differentiation. In an in vitro model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fc95800965bbab7e9d2d9f4bcaa018
https://doi.org/10.1016/j.neulet.2005.03.044

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The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein

Autor: Gordon D. Strachan, Rocky S. Tuan, Ravikumar Rallapalli, Kelly L. Jordan-Sciutto, David J. Hall

Publikováno v: Journal of Cellular Biochemistry. 88:557-568

Several proteins with important roles in oncogenesis have been shown to regulate the function of the E2F-1 transcription factor, which is known to activate the expression of genes required for proliferation and apoptosis. Here we identify the MDMX on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c00168cd6c730538aff6e9b1ae2cee1
https://doi.org/10.1002/jcb.10318

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A Transcriptionally Inactive E2F-1 Targets the MDM Family of Proteins for Proteolytic Degradation

Autor: Toulouse P. Lafond, Ravikumar Rallapalli, Bruna Pucci, David J. Hall, Gordon D. Strachan

Publikováno v: Journal of Biological Chemistry. 276:45677-45685

E2F-1-activated transcription promotes cell cycle progression and apoptosis. These functions are regulated by several factors including the E2F-1-binding protein MDM2 and the retinoblastoma protein pRb. Using a yeast two-hybrid screen we have identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6e08e5e079b1d0887649c3d3368100
https://doi.org/10.1074/jbc.m103765200

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E2F1 induces cell death, calpain activation, and MDMX degradation in a transcription independent manner implicating a novel role for E2F1 in neuronal loss in SIV encephalitis

Autor: Robert Siman, David J. Hall, Maya A. Koike, Gordon D. Strachan, Kelly L. Jordan-Sciutto

Publikováno v: Journal of cellular biochemistry. 96(4)

The E2F1 transcription factor can initiate proliferation or apoptosis, the latter by both transcription-dependent and -independent mechanisms. Recently, an E2F1 mutant lacking the DNA binding domain, E2F1(180–437), has been implicated in degradatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da536b17447b14bfd52dd2b2aca3f6e
https://pubmed.ncbi.nlm.nih.gov/16088944

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Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death

Autor: Gordon D. Strachan, Kelly L. Jordan-Sciutto, Liya Avshalumov Ostrow

Publikováno v: Biochemical and biophysical research communications. 336(2)

The fetal Alz-50 clone 1 (FAC1) protein exhibits altered expression patterns in neurodegenerative disease. Though it has been shown to bind DNA in a site-specific, phosphorylation-dependent manner, its cellular function remains unknown. Here, we demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1828f062eaf2cc49ff1018f0bdea8c6e
https://pubmed.ncbi.nlm.nih.gov/16137655

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Chemokine- and neurotrophic factor-induced changes in E2F1 localization and phosphorylation of the retinoblastoma susceptibility gene product (pRb) occur by distinct mechanisms in murine cortical cultures

Autor: Amanda S. Kopp, Gordon D. Strachan, Maya A. Koike, Kathleen L. Morgan, Kelly L. Jordan-Sciutto

Publikováno v: Experimental neurology. 193(2)

The retinoblastoma susceptibility gene product (pRb) and E2F1 have been found to exhibit altered localization and increased staining in several neurodegenerative diseases. We have observed similar localization in primary murine cortical cultures trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd1334970a1d6008db2751e31f7dd74
https://pubmed.ncbi.nlm.nih.gov/15869948

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Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells

Autor: Rocky S. Tuan, David J. Hall, Gordon D. Strachan, Ravikumar Rallapalli

Publikováno v: Journal of cellular biochemistry. 89(3)

The MDMX gene product is related to the MDM2 oncoprotein, both of which interact with the p53 tumor suppressor. A novel transcript of the MDMX gene has been previously identified that has a short internal deletion of 68 base pairs, producing a shift

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f716717891e33dd9eeb1edd3a1d1247f
https://pubmed.ncbi.nlm.nih.gov/12761890

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A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity

Autor: B Cho, W E Mercer, Gordon D. Strachan, David J. Hall, Ravikumar Rallapalli

Publikováno v: The Journal of biological chemistry. 274(12)

The MDMX gene product is related to the MDM2 oncoprotein, both of which interact with the p53 tumor suppressor. We have identified a novel transcript of the MDMX gene that is expressed in a variety of cell lines, and in particular, in growing and tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd20aa42ba39409815311ce4cbe4b720
https://pubmed.ncbi.nlm.nih.gov/10075736

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