Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Gordon D McLaren"'
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0261690 (2021)
BackgroundIn hemochromatosis, causes of abdominal pain and its associations with cirrhosis are poorly understood.MethodsWe retrospectively compared characteristics of referred hemochromatosis probands with HFE p.C282Y homozygosity with/without biopsy
Externí odkaz:
https://doaj.org/article/702bf71fa79342d5b813cfee7099591c
Autor:
James C Barton, Howard H Wiener, Ronald T Acton, Paul C Adams, John H Eckfeldt, Victor R Gordeuk, Emily L Harris, Christine E McLaren, Helen Harrison, Gordon D McLaren, David M Reboussin
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0232125 (2020)
BackgroundFew cross-sectional studies report iron deficiency (ID) prevalence in women of different race/ethnicity and ages in US or Canada.Materials and methodsWe evaluated screening observations on women who participated between 2001-2003 in a cross
Externí odkaz:
https://doaj.org/article/87680c72321248f2bb7d466c6ba83ce4
Autor:
Colin P Farrell, Jessica R Overbey, Hetanshi Naik, Danielle Nance, Gordon D McLaren, Christine E McLaren, Luming Zhou, Robert J Desnick, Charles J Parker, John D Phillips
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163322 (2016)
Both familial and sporadic porphyria cutanea tarda (PCT) are iron dependent diseases. Symptoms of PCT resolve when iron stores are depleted by phlebotomy, and a sequence variant of HFE (C282Y, c.843G>A, rs1800562) that enhances iron aborption by redu
Externí odkaz:
https://doaj.org/article/ce3d2d5c55b04405afc0ca956d1f0a42
Autor:
Paul C Adams, James C Barton, Gordon D McLaren, Ronald T Acton, Mark Speechley, Christine E McLaren, David M Reboussin, Catherine Leiendecker-Foster, Emily L Harris, Beverly M Snively, Thomas Vogt, Phyliss Sholinsky, Elizabeth Thomson, Fitzroy W Dawkins, Victor R Gordeuk, John H Eckfeldt
Publikováno v:
Canadian Journal of Gastroenterology, Vol 23, Iss 11, Pp 769-772 (2009)
BACKGROUND: The HEmochromatosis and IRon Overload Screening (HEIRS) Study provided data on a racially, ethnically and geographically diverse cohort of participants in North America screened from primary care populations.
Externí odkaz:
https://doaj.org/article/6e53e75d0a134cf2a8ea25d468034d8f
Autor:
Gordon D McLaren, Christine E McLaren, Paul C Adams, James C Barton, David M Reboussin, Victor R Gordeuk, Ronald T Acton, Emily L Harris, Mark R Speechley, Phyliss Sholinsky, Fitzroy W Dawkins, Beverly M Snively, Thomas M Vogt, John H Eckfeldt, for the Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators
Publikováno v:
Canadian Journal of Gastroenterology, Vol 22, Iss 11, Pp 923-930 (2008)
BACKGROUND: Patients with hemochromatosis may suffer organ damage from iron overload, often with serious clinical consequences.
Externí odkaz:
https://doaj.org/article/3c6c7556d4464ce498ebe6998618e4c6
Autor:
Paul C Adams, Christine E McLaren, Mark Speechley, Gordon D McLaren, James C Barton, John H Eckfeldt
Publikováno v:
Canadian Journal of Gastroenterology, Vol 27, Iss 7, Pp 390-392 (2013)
BACKGROUND: Many patients referred for an elevated serum ferritin level
Externí odkaz:
https://doaj.org/article/646ac36f94da454ab432c33780c9fa2a
Autor:
Christine E McLaren, Stela McLachlan, Chad P Garner, Chris D Vulpe, Victor R Gordeuk, John H Eckfeldt, Paul C Adams, Ronald T Acton, Joseph A Murray, Catherine Leiendecker-Foster, Beverly M Snively, Lisa F Barcellos, James D Cook, Gordon D McLaren
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38339 (2012)
The existence of multiple inherited disorders of iron metabolism suggests genetic contributions to iron deficiency. We previously performed a genome-wide association study of iron-related single nucleotide polymorphisms (SNPs) using DNA from white me
Externí odkaz:
https://doaj.org/article/d5755e27d1bf4d418711620200f170ca
Autor:
Christine E McLaren, Chad P Garner, Clare C Constantine, Stela McLachlan, Chris D Vulpe, Beverly M Snively, Victor R Gordeuk, Debbie A Nickerson, James D Cook, Catherine Leiendecker-Foster, Kenneth B Beckman, John H Eckfeldt, Lisa F Barcellos, Joseph A Murray, Paul C Adams, Ronald T Acton, Anthony A Killeen, Gordon D McLaren
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17390 (2011)
The existence of multiple inherited disorders of iron metabolism in man, rodents and other vertebrates suggests genetic contributions to iron deficiency. To identify new genomic locations associated with iron deficiency, a genome-wide association stu
Externí odkaz:
https://doaj.org/article/b65e48c2eebe475e8db2cd147aec2f3d
Autor:
James C. Barton, Christine E. McLaren, Wen-pin Chen, Grant A. Ramm, Gregory J. Anderson, Lawrie W. Powell, V. Nathan Subramaniam, Paul C. Adams, Pradyumna D. Phatak, Lyle C. Gurrin, John D. Phillips, Charles J. Parker, Mary J. Emond, Gordon D. McLaren
Publikováno v:
Annals of Hepatology, Vol 17, Iss 5, Pp 871-879 (2018)
Introduction and aim. We sought to identify independent risk factors for cirrhosis in HFE p.C282Y homozygotes in a cross-sectional study.Material and methods. We evaluated 368 p.C282Y homozygotes who underwent liver biopsy and compared characteristic
Externí odkaz:
https://doaj.org/article/b614345361c84b339e0dc7dc77a70630
Autor:
James C. Barton, Gautam Rishi, Christine E. McLaren, V. Nathan Subramaniam, Eriza S. Secondes, Daniel F. Wallace, Gordon D. McLaren, Wen-Pin Chen, Louise E. Ramm, Lawrie W. Powell, Grant A. Ramm
Publikováno v:
Blood Cells Mol Dis
Glyceronephosphate O-acyltransferase (GNPAT) p.D519G (rs11558492) was identified as a genetic modifier correlated with more severe iron overload in hemochromatosis through whole-exome sequencing of HFE p.C282Y homozygotes with extreme iron phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66fbdff05caeb4cd03d6a8161529007
https://europepmc.org/articles/PMC7786288/
https://europepmc.org/articles/PMC7786288/
