Zobrazeno 1 - 10 of 188 pro vyhledávání: '"Gordon C. K. Roberts"'
1
Solution structure of the cytochrome P450 reductase–cytochrome c complex determined by neutron scattering
Autor: Emma Lloyd Raven, Anne L. Martel, Gordon C. K. Roberts, Juliette M. Devos, Jaswir Basran, Samuel L. Freeman
Publikováno v: The Journal of Biological Chemistry
Freeman, S L, Martel, A, Devos, J M, Basran, J, Raven, E L & Roberts, G C K 2018, ' Solution structure of the cytochrome P450 reductase–cytochrome c complex determined by neutron scattering ', Journal of Biological Chemistry, vol. 293, no. 14, pp. 5210-5219 . https://doi.org/10.1074/jbc.RA118.001941
'Journal of Biological Chemistry ', vol: 293, pages: 5210-5219 (2018)
Electron transfer in all living organisms critically relies on formation of complexes between the proteins involved. The function of these complexes requires specificity of the interaction to allow for selective electron transfer but also a fast turn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3284430df919f253412e9a277935a8db
http://europepmc.org/articles/PMC5892573
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2
The role of protein dynamics in allosteric effects—introduction
Autor: Gordon C. K. Roberts
Publikováno v: Biophysical Reviews. 7:161-163
Certainly no subject or field is making more progress on so many fronts at the present moment, than biology, and if we were to name the most powerful assumption of all, which leads one on and on in an attempt to understand life, it is that all things
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb84e5a862a4198d06305987a8094ba
https://doi.org/10.1007/s12551-015-0174-6
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3
Complete 1H, 15N and 13C resonance assignments of Bacillus cereus metallo-β-lactamase and its complex with the inhibitor R-thiomandelic acid
Autor: Andreas Ioannis Karsisiotis, Gordon C. K. Roberts, Christian Damblon
Publikováno v: Biomolecular Nmr Assignments
β-Lactamases inactivate β-lactam antibiotics by hydrolysis of their endocyclic β-lactam bond and are a major cause of antibiotic resistance in pathogenic bacteria. The zinc dependent metallo-β-lactamase enzymes are of particular concern since the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cc404238fde8666747768e4bdfffdc
http://europepmc.org/articles/PMC4145196
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4
RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover
Autor: Neil Bate, Igor L. Barsukov, Thomas Zacharchenko, David R. Critchley, Gordon C. K. Roberts, Paul R. Elliott, Christoph Ballestrem, Ricky Tsang, Fiona Hey, Alexandre R. Gingras, Benjamin T. Goult
Publikováno v: The Journal of Biological Chemistry
Background: Talin mediates RIAM-dependent integrin activation and binds vinculin, which stabilizes adhesions. Results: Structural and biochemical data show that vinculin inhibits RIAM binding to the compact N-terminal region of the talin rod, a regio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83eb04e1a4176b73452ab8bd2b996913
https://doi.org/10.1074/jbc.m112.438119
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5
Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain
Autor: Jaswir Basran, Igor L. Barsukov, David R. Critchley, Gordon C. K. Roberts, Clive R. Bagshaw, Kate L. Wegener, Iain D. Campbell
Talin is a large cytoskeletal protein that is involved in coupling the integrin family of cell adhesion molecules to the actin cytoskeleton, colocalising with the integrins in focal adhesions (FAs). However, at the leading edge of motile cells, talin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfbeabb5f802586582e67d093f2e4e7
https://ora.ox.ac.uk/objects/uuid:ff1c4639-917c-4df9-af8c-e74df27241f1
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6
The Role of Active Site Flexible Loops in Catalysis and of Zinc in Conformational Stability of Bacillus cereus 569/H/9 β-Lactamase*
Autor: Andreas Ioannis Karsisiotis, Andr eacute Matagne, Micha eumll Nigen, Christina Redfield, Gordon C. K. Roberts, Nicolas Willet, Caroline Montagner, Christian Damblon, Mireille Dumoulin, Olivier Jacquin
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (31), pp.16124-16137. ⟨10.1074/jbc.M116.719005⟩
Journal of Biological Chemistry 31 (291), 16124-16137. (2016)
Metallo-β-lactamases catalyse the hydrolysis of most β-lactam antibiotics and hence represent a major clinical concern. The development of inhibitors for these enzymes is complicated by the diversity and flexibility of their substrate binding sites
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f838d3b0a120da0b17b7c0910bd1b2d
https://europepmc.org/articles/PMC4965562/
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9
Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4
Autor: Yassar Farooq, Gordon C. K. Roberts
Publikováno v: Biochemical Journal. 432:485-494
We have incorporated CYP3A4 (cytochrome P450 3A4) and CPR (NADPH-cytochrome P450 reductase) into liposomes with a high lipid/protein ratio by an improved method. In the purified proteoliposomes, CYP3A4 binds testosterone with Kd (app)=36±6 μM and H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3370576291dca5dd45b33d05308ec013
https://doi.org/10.1042/bj20100744
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10
The domain structure of talin: Residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site
Autor: Benjamin T. Goult, Igor L. Barsukov, Gordon C. K. Roberts, Neil Bate, David R. Critchley, Alexandre R. Gingras
Publikováno v: Febs Letters
Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. Its rod region consists of a series of helical bundles. Here we show that residues 1815–1973 form a 5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3757d231e06c34309b5172dd678a22f
https://doi.org/10.1016/j.febslet.2010.04.028
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