Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Gordon C, Weir"'
Autor:
Anna French, Jennifer Hollister-Lock, Brooke A. Sullivan, Eline Stas, Albert J. Hwa, Gordon C. Weir, Susan Bonner-Weir
Publikováno v:
Cell Transplantation, Vol 33 (2024)
Human islets can be transplanted into the portal vein for T1 diabetes, and a similar procedure is being used in a clinical trial for stem cell–derived beta-like cells. Efforts have been underway to find an alternative transplant site that will fost
Externí odkaz:
https://doaj.org/article/5fb2fd709e644bdc8df399532be47dd4
Autor:
Gordon C. Weir, Susan Bonner-Weir
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
As diabetes continues to grow as major health problem, there has been great progress in understanding the important role of pancreatic beta-cells in its pathogenesis. Diabetes develops when the normal interplay between insulin secretion and the insul
Externí odkaz:
https://doaj.org/article/2d690057f3494adf9b5204f651602268
Autor:
Aref G. Ebrahimi, Jennifer Hollister-Lock, Brooke A. Sullivan, Ryohei Tsuchida, Susan Bonner-Weir, Gordon C. Weir
Publikováno v:
Molecular Metabolism, Vol 35, Iss , Pp - (2020)
Objective: As diabetes develops, marked reductions of insulin secretion are associated with very modest elevations of glucose. We wondered if these glucose changes disrupt beta cell differentiation enough to account for the altered function. Methods:
Externí odkaz:
https://doaj.org/article/be98603d6e7e469786b8205045c7c2e4
Autor:
Ahmed I Mahmoud, Francisco X Galdos, Katherine A Dinan, Mark P Jedrychowski, Jeffrey C Davis, Ana Vujic, Inbal Rachmin, Christian Shigley, James R Pancoast, Samuel Lee, Jennifer Hollister-Lock, Catherine M MacGillivray, Steven P Gygi, Douglas A Melton, Gordon C Weir, Richard T Lee
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204595 (2018)
The in vivo microenvironment of tissues provides myriad unique signals to cells. Thus, following isolation, many cell types change in culture, often preserving some but not all of their in vivo characteristics in culture. At least some of the in vivo
Externí odkaz:
https://doaj.org/article/105ba49f67b348fb8916c00f5caeeb50
Autor:
Siddharth Jhunjhunwala, Volkan Yesilyurt, Omid Veiseh, Chandrabali Bhattacharya, Amanda L. Facklam, Daniel G. Anderson, Robert Langer, Gordon C. Weir, Lisa R. Volpatti, Suman Bose, Amy Wang, Yaoyu Tang, Dale L. Greiner, Collin McGladrigan, Devina Thiono, Jennifer Hollister-Lock
Publikováno v:
Nature biomedical engineering
The long-term function of transplanted therapeutic cells typically requires systemic immune suppression. Here, we show that a retrievable implant comprising a silicone reservoir and a porous polymeric membrane protects human cells encapsulated in it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608f396395bfff3de37894da9cb7639c
http://europepmc.org/articles/PMC8051527
http://europepmc.org/articles/PMC8051527
Autor:
Klearchos K Papas, Melena D Bellin, David E R Sutherland, Thomas M Suszynski, Jennifer P Kitzmann, Efstathios S Avgoustiniatos, Angelika C Gruessner, Kathryn R Mueller, Gregory J Beilman, Appakalai N Balamurugan, Gopalakrishnan Loganathan, Clark K Colton, Maria Koulmanda, Gordon C Weir, Josh J Wilhelm, Dajun Qian, Joyce C Niland, Bernhard J Hering
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134428 (2015)
BackgroundReliable in vitro islet quality assessment assays that can be performed routinely, prospectively, and are able to predict clinical transplant outcomes are needed. In this paper we present data on the utility of an assay based on cellular ox
Externí odkaz:
https://doaj.org/article/3b1106a0d9a04b4484572e0579606e02
Autor:
Hok Hei Tam, Daniel G. Anderson, Dale L. Greiner, Hye Jung Han, Marissa Griffin, Katy N. Olafson, Robert Langer, Peter Müller, James J. McGarrigle, Adam Graham, Shady Farah, Piotr S. Kowalski, Joshua C. Doloff, Jose Oberholzer, Jennifer Hollister-Lock, Ashley Meng, Malia McAvoy, Keval Vyas, Gordon C. Weir, Atieh Sadraei
Publikováno v:
Nature materials
Implantable medical devices have revolutionized modern medicine. However, immune-mediated foreign body response (FBR) to the materials of these devices can limit their function or even induce failure. Here we describe long-term controlled-release for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280f90c9adbdb3bc79ae6a844382cbdd
https://doi.org/10.1038/s41563-019-0377-5
https://doi.org/10.1038/s41563-019-0377-5
Autor:
Francisco Caballero, Karolina Siniakowicz, Jennifer Hollister-Lock, Luisa Duran, Hitoshi Katsuta, Takatsugu Yamada, Ji Lei, Shaoping Deng, Gunilla T. Westermark, James Markmann, Susan Bonner-Weir, Gordon C. Weir M.D.
Publikováno v:
Cell Transplantation, Vol 23 (2014)
There is great interest in the potential of the human endocrine pancreas for regeneration by β-cell replication or neogenesis. Our aim was to explore this potential in adult human pancreases and in both islet and exocrine tissue transplanted into mi
Externí odkaz:
https://doaj.org/article/38a5c989a30e450a9e2c506a315f3383
Autor:
Susan Bonner-Weir, Gordon C. Weir
Publikováno v:
J Clin Invest
BACKGROUND: The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin, and a reduction of β cell mass. There is a long-standing debate as to the relative contribution of these factors to clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832b7b91e9681c637980f3f751e18959
https://pubmed.ncbi.nlm.nih.gov/33905373
https://pubmed.ncbi.nlm.nih.gov/33905373
Autor:
Uriel Barkai Ph.D., Gordon C. Weir, Clark K. Colton, Barbara Ludwig, Stefan R. Bornstein, Mathias D. Brendel, Tova Neufeld, Chezi Bremer, Assaf Leon, Yoav Evron, Karina Yavriyants, Dimitri Azarov, Baruch Zimermann, Shiri Maimon, Noa Shabtay, Maria Balyura, Tania Rozenshtein, Pnina Vardi, Konstantin Bloch, Paul De Vos, Avi Rotem
Publikováno v:
Cell Transplantation, Vol 22 (2013)
The current epidemic of diabetes with its overwhelming burden on our healthcare system requires better therapeutic strategies. Here we present a promising novel approach for a curative strategy that may be accessible for all insulin-dependent diabete
Externí odkaz:
https://doaj.org/article/16b3b5a5d3cc465aa8cfdf841bc10acf