Zobrazeno 1 - 10
of 308
pro vyhledávání: '"Gordon C, Jayson"'
Autor:
Margherita Carucci, Andrew Clamp, Cong Zhou, Chris Hurt, Rosalind Glasspool, Phillip J. Monaghan, Sally Thirkettle, Michael Wheatley, Madia Mahmood, Monica Narasimham, Tracy Cox, Hilary Morrison, Susan Campbell, Annmarie Nelson, Daniella Holland-Hart, Noreen Hopewell-Kelly, Abin Thomas, Catharine Porter, Magdalena Slusarczyk, Alys Irving, Caroline Dive, Richard Adams, Gordon C. Jayson
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Anti-angiogenic, VEGF inhibitors (VEGFi) increase progression-free survival (PFS) and, in some cases, overall survival in many solid tumours. However, their use has been compromised by a lack of informative biomarkers. We have sho
Externí odkaz:
https://doaj.org/article/2cb2b6eb4c584bf9a3d37059d285edbd
Autor:
Robert D. Morgan, Cristina Ferreras, Isabel Peset, Egle Avizienyte, Andrew G. Renehan, Richard J. Edmondson, Alexander D. Murphy, Shibani Nicum, Thomas Van Brussel, Andrew R. Clamp, Diether Lambrechts, Cong Zhou, Gordon C. Jayson
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Highlights Tissue microarrays and germline DNA from women recruited to the phase 3 trial, ICON7, underwent quantitative immunofluorescence for c-MET/VEGFR-2 co-expression and genetic sequencing for single nucleotide polymorphisms (SNPs) VEGF-pathway
Externí odkaz:
https://doaj.org/article/1954157b03284a32b79f59f1c52385eb
Autor:
Reem D. Mahmood, Danielle Shaw, Tine Descamps, Cong Zhou, Robert D. Morgan, Saifee Mullamitha, Mark Saunders, Nerissa Mescallado, Alison Backen, Karen Morris, Ross A. Little, Susan Cheung, Yvonne Watson, James P. B. O’Connor, Alan Jackson, Geoff J. M. Parker, Caroline Dive, Gordon C. Jayson
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Patients with metastatic colorectal cancer are treated with cytotoxic chemotherapy supplemented by molecularly targeted therapies. There is a critical need to define biomarkers that can optimise the use of these therapies to maxim
Externí odkaz:
https://doaj.org/article/357e10ddf5c4403488351151c9365ef5
Autor:
Louisa Nelson, Anthony Tighe, Anya Golder, Samantha Littler, Bjorn Bakker, Daniela Moralli, Syed Murtuza Baker, Ian J. Donaldson, Diana C. J. Spierings, René Wardenaar, Bethanie Neale, George J. Burghel, Brett Winter-Roach, Richard Edmondson, Andrew R. Clamp, Gordon C. Jayson, Sudha Desai, Catherine M. Green, Andy Hayes, Floris Foijer, Robert D. Morgan, Stephen S. Taylor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
High-grade serous ovarian carcinoma is often associated with TP53 mutation and chromosomal instability (CIN). Here, the authors generate ex vivo cultures from biopsies and ascites of patients and perform characterization to evaluate CIN mechanisms an
Externí odkaz:
https://doaj.org/article/5f96b03935524c6e8d18bbc5878047b4
Autor:
Chloe A. Logue, MBChB, MRes, Julia Pugh, BNurs (hons), MSc, PGDip, Philip Foden, BSc, MSc, Reem D. Mahmood, MBChB, MRCP, Robert D. Morgan, MBBS, Claire Mitchell, MBBS, MRCP, PhD, Jurjees Hasan, MSc, MD, FRCP, Andrew R. Clamp, MA, BMBCh, PhD, Gordon C. Jayson, PhD, FRCP
Publikováno v:
Sexual Medicine, Vol 10, Iss 1, Pp 100465- (2022)
ABSTRACT: Introduction: Up to 75% of women with ovarian cancer experience psychosexual morbidity and approximately 15–20% of women with ovarian cancer have a germline BRCA1/2 mutation (gBRCAm). However, psychosexual morbidity remains unexplored in
Externí odkaz:
https://doaj.org/article/b0123162747b48f18ee2caf28eb9129c
Autor:
Anne Marie Sowerbutts, Simon Lal, Jana Sremanakova, Andrew R. Clamp, Gordon C. Jayson, Antje Teubner, Lisa Hardy, Chris Todd, Anne-Marie Raftery, Eileen Sutton, Robert D. Morgan, Alexander J. Vickers, Sorrel Burden
Publikováno v:
BMC Palliative Care, Vol 18, Iss 1, Pp 1-10 (2019)
Abstract Background Malnutrition is a problem in advanced cancer, particularly ovarian cancer where malignant bowel obstruction (MBO) is a frequent complication. Parenteral nutrition is the only way these patients can received adequate nutrition and
Externí odkaz:
https://doaj.org/article/cb4fc2e7f25545448b3e1b621580c5e8
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Cancer in patients with chronic kidney disease (CKD) is an added burden to their overall morbidity and mortality. Cancer can be a cause or an effect of CKD. In CKD patients, a better understanding of cancer distribution and associ
Externí odkaz:
https://doaj.org/article/17ec03ed68414cdfa629fcac26600cda
Autor:
Fahad Ayesh Alharthi, Garrett T. Potter, Gordon C. Jayson, George F. S. Whitehead, Iñigo J. Vitórica-Yrezábal, John M. Gardiner
Publikováno v:
Organic Letters. 25:2196-2200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8c1cf97551a32ae98f7992fb926b4b
https://doi.org/10.1021/acs.orglett.3c00255
https://doi.org/10.1021/acs.orglett.3c00255
Autor:
Robert D. Morgan, Andrew R. Clamp, Daniel J. White, Marcus Price, George J. Burghel, W. David J. Ryder, Reem D. Mahmood, Alexander D. Murphy, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Chelsey Wheeler, Emma Buckley, Joanna Truelove, Georgia King, Yasmina Ainaoui, Sanjeev S. Bhaskar, Joseph Shaw, D. Gareth R. Evans, Bedirhan Kilerci, Simon P. Pearce, Gerard Brady, Caroline Dive, James P.B. O'Connor, Andrew J. Wallace, Dominic G. Rothwell, Richard J. Edmondson, Gordon C. Jayson
Publikováno v:
Clinical Cancer Research. :OF1-OF10
Purpose: A single maintenance course of a PARP inhibitor (PARPi) improves progression-free survival (PFS) in germline BRCA1/2-mutant high-grade serous ovarian cancer (gBRCAm-HGSOC). The feasibility of a second maintenance course of PARPi was unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0ce146e67df3eacbdf34201db33125b
https://doi.org/10.1158/1078-0432.ccr-22-3282
https://doi.org/10.1158/1078-0432.ccr-22-3282
Autor:
Gordon C. Jayson, Cong Zhou, Alison Backen, Laura Horsley, Kalena Marti-Marti, Danielle Shaw, Nerissa Mescallado, Andrew Clamp, Mark P. Saunders, Juan W. Valle, Saifee Mullamitha, Mike Braun, Jurjees Hasan, Delyth McEntee, Kathryn Simpson, Ross A. Little, Yvonne Watson, Susan Cheung, Caleb Roberts, Linda Ashcroft, Prakash Manoharan, Stefan J. Scherer, Olivia del Puerto, Alan Jackson, James P. B. O’Connor, Geoff J. M. Parker, Caroline Dive
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Identification of response biomarkers is a key step towards the development of personalised care. Here, Jayson et al. identify plasma Tie2 as a biomarker for the response of the tumor vasculature to anti-angiogenics in patients with metastatic colore
Externí odkaz:
https://doaj.org/article/51bffec067d642f8a6e2d9a8af7b2752