Dysregulation of NF-kB in glandular epithelial cells results in Sjögren's-like features.

Autor: Xiaoyan Wang, Abeer Shaalan, Silvia Liefers, Julie Coudenys, Dirk Elewaut, Gordon B Proctor, Hendrika Bootsma, Frans G M Kroese, Sarah Pringle

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0200212 (2018)

The autoimmune disease primary Sjögren's syndrome (pSS) is characterized by hypofunction of the salivary glands (SGs), the cause of which is not correlated to lymphocytic SG infiltration, as prevailing dogma often states. We knocked out the NF-κB p

Externí odkaz: https://doaj.org/article/8e3ef71915434afea7ee0d79750211ac

SIgA binding to mucosal surfaces is mediated by mucin-mucin interactions.

Autor: Hannah L Gibbins, Gordon B Proctor, Gleb E Yakubov, Stephen Wilson, Guy H Carpenter

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119677 (2015)

The oral mucosal pellicle is a layer of absorbed salivary proteins, including secretory IgA (SIgA), bound onto the surface of oral epithelial cells and is a useful model for all mucosal surfaces. The mechanism by which SIgA concentrates on mucosal su

Externí odkaz: https://doaj.org/article/7a7c7139fac5461da3208888c82ad140

Abundance and diversity of resistomes differ between healthy human oral cavities and gut

Autor: Victoria R. Carr, Elizabeth A. Witherden, Sunjae Lee, Saeed Shoaie, Peter Mullany, Gordon B. Proctor, David Gomez-Cabrero, David L. Moyes

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

Antimicrobial resistance (AMR) represents a global health threat. Here, the authors analyse the oral and gut resistomes from metagenomes of diverse populations and find that the oral resistome harbours higher abundance but lower diversity of antimicr

Externí odkaz: https://doaj.org/article/735991a569e94940aaa4225c473a42a0

Contributors

Autor: Yasutada Akiba, Denise Al Alam, Rana Al-Sadi, Qasim Aziz, Eric J. Battaglioli, Adil E. Bharucha, Richard S. Blumberg, Natacha Bohin, Joel C. Bornstein, Stuart M. Brierley, Simon J.H. Brookes, Joel Castro, Eugene B. Chang, Benoit Chassaing, Mary Cheung, Matthew A. Ciorba, Sheila E. Crowe, Michael Czerwinski, Soula Danopoulos, Soumita Das, Peter J. Dempsey, Gerco den Hartog, Hideki Enomoto, Andelain Erickson, Peter B. Ernst, Adam D. Farmer, Jaime P.P. Foong, Mark R. Frey, Andrew T. Gewirtz, Fayez K. Ghishan, Fiona M. Gribble, Luke Grundy, Marlene M. Hao, Andrea M. Harrington, Grant W. Hennig, Hongzhen Hu, Jan D. Huizinga, Shankar S. Iyer, Izumi Kaji, Purna C. Kashyap, Jonathan D. Kaunitz, Jennifer S. Labus, Brigitte Lavoie, Cambrian Y. Liu, Thomas Y. Ma, Xiaoya Ma, Gary M. Mawe, Juanita L. Merchant, Jeannette S. Messer, Larry Miller, Bruce D. Naliboff, Mark T. Nelson, Donald F. Newgreen, Prashant Nighot, Monica Passi, D. Brent Polk, Maria J. Pozo, Frank Reimann, Geoffrey P. Roberts, Bani C. Roland, James K. Ruffle, Hyder Said, Linda C. Samuelson, Michael A. Schumacher, Yatrik M. Shah, Terez Shea-Donohue, Noah F. Shroyer, Jason R. Spence, Nick J. Spencer, Stephanie N. Spohn, Lincon A. Stamp, William F. Stenson, Miyako Takaki, Kirsten Tillisch, Toshihiro Uesaka, Gijs R. van den Brink, Willemijn A. van Dop, Anil Vegesna, Jakob von Moltke, Arnold Wald, B. Florien Westendorp, Mathew Whitson, Jackie D. Wood, Hua Xu, Vincent W. Yang, Heather M. Young, Vincent B. Young, Nada A. Abumrad, Waddah A. Alrefai, Rana Ammoury, Gregory J. Anderson, Shinji Asano, Giorgos Bamias, Yangzom D. Bhutia, Niviann M. Blondet, Patrick Borel, Vincenza Cifarelli, James F. Collins, Robert J. Cousins, Nicholas O. Davidson, Paul A. Dawson, Guillaume de Lartigue, Charles Desmarchelier, Pradeep K. Dudeja, Shireen R.L. Flores, Vadivel Ganapathy, Chiara Ghezzi, Ravinder K. Gill, Fred S. Gorelick, Matthew B. Grisham, Earl H. Harrison, Gail A. Hecht, Dawn A. Israel, James D. Jamieson, Bryson W. Katona, Pawel R. Kiela, Rachel E. Kopec, Kris V. Kowdley, Nicholas F. LaRusso, Seong M. Lee, Rodger A. Liddle, Juan P. Liuzzi, Donald D.F. Loo, John P. Lynch, Anatoliy I. Masyuk, Tatyana V. Masyuk, Donald J. Messner, Mark B. Meyer, Karen F. Murray, Ebba Nexo, Curtis T. Okamoto, Bernardo Ortega, Stephen Pandol, Richard M. Peek, J. Wesley Pike, Shubha Priyamvada, Gordon B. Proctor, Vazhaikkurichi M. Rajendran, Helen E. Raybould, Jesus Rivera-Nieves, Hamid M. Said, Hideki Sakai, Seema Saksena, Monica Sala-Rabanal, Jörg-Dieter Schulzke, Ursula E. Seidler, Abeer K. Shaalan, Irshad A. Sheikh, Jay R. Thiagarajah, Alan S. Verkman, Xiaoyu Wang, Paul A. Welling, Allan W. Wolkoff, Ernest M. Wright

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51874f576fda423b8a309cb9f57d8157
https://doi.org/10.1016/b978-0-12-809954-4.09991-6

Systematic review and meta-analysis of salivary protein concentration in Parkinson's disease

Autor: Joseph M, Masters, Jonathan, Bestwick, Thomas T, Warner, Gavin, Giovannoni, Gordon B, Proctor, Alastair J, Noyce

Publikováno v: Movement disorders : official journal of the Movement Disorder Society. 30(14)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6b15e9c5aeb72c377d5a529e5110534
https://pubmed.ncbi.nlm.nih.gov/26583568