Zobrazeno 1 - 10
of 2 099
pro vyhledávání: '"Gordon B Mills"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 45, Iss , Pp 100932- (2023)
Acquired uniparental disomy (aUPD) is a chromosomal alteration that can lead to homozygosity of existing aberrations. We used data from The Cancer Genome Atlas SNP-based arrays to identify distinct and common aUPD profiles in lung adenocarcinoma (LUA
Externí odkaz:
https://doaj.org/article/13a76921117242a09c9420ee7a3fd600
Autor:
Li Zhang, Xi Li, Gang Chen, Yu Fu, Bin Yang, Wenting Li, Jingbo Liu, Xu Qin, Gordon B Mills, Yaoyuan Cui, Xingyuan Hu, Funian Lu, Tianyu Qin, Zhe Hu, Ensong Guo, Junpeng Fan, Rourou Xiao, Dianxing Hu, Wenju Peng, Beibei Wang, Chaoyang Sun
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Mismatch repair deficiency (dMMR) is a well-recognized biomarker for response to immune checkpoint blockade (ICB). Strategies to convert MMR-proficient (pMMR) to dMMR phenotype with the goal of sensitizing tumors to ICB are highly sought.
Externí odkaz:
https://doaj.org/article/885194f4d4ed49448a58d817aacaae43
Autor:
Yiu Huen Tsang, Yumeng Wang, Kathleen Kong, Caitlin Grzeskowiak, Oksana Zagorodna, Turgut Dogruluk, Hengyu Lu, Nicole Villafane, Venkata Hemanjani Bhavana, Daniela Moreno, Sarah H Elsea, Han Liang, Gordon B Mills, Kenneth L Scott
Publikováno v:
eLife, Vol 9 (2020)
The melanoma-associated antigen family A (MAGEA) antigens are expressed in a wide variety of malignant tumors but not in adult somatic cells, rendering them attractive targets for cancer immunotherapy. Here we show that a number of cancer-associated
Externí odkaz:
https://doaj.org/article/b63be19c78e4404ea4ececcfde2c8abb
Autor:
Noriyuki Sasaki, Takeshi Iwaya, Takehiro Chiba, Masashi Fujita, Zhenlin Ju, Fumitaka Endo, Mizunori Yaegashi, Tsuyoshi Hachiya, Ryo Sugimoto, Tamotsu Sugai, Doris R Siwak, Lance A Liotta, Yiling Lu, Gordon B Mills, Hidewaki Nakagawa, Satoshi S Nishizuka
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0239966 (2020)
Circulating tumor DNA (ctDNA) is released from tumor cells into blood in advanced cancer patients. Although gene mutations in individual tumors can be diverse and heterogenous, ctDNA has the potential to provide comprehensive biomarker information. H
Externí odkaz:
https://doaj.org/article/3d3ac3aee9d64e55b0d52d0eec6c446f
Autor:
Dmitri Rozanov, Anton Cheltsov, Aaron Nilsen, Christopher Boniface, Isaac Forquer, James Korkola, Joe Gray, Jeffrey Tyner, Cristina E Tognon, Gordon B Mills, Paul Spellman
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0205623 (2019)
To determine the target of the recently identified lead compound NSC130362 that is responsible for its selective anti-cancer efficacy and safety in normal cells, structure-activity relationship (SAR) studies were conducted. First, NSC13062 was valida
Externí odkaz:
https://doaj.org/article/725ef1333a644e51a8aca39671124606
Autor:
Ileabett M Echevarría‐Vargas, Patricia I Reyes‐Uribe, Adam N Guterres, Xiangfan Yin, Andrew V Kossenkov, Qin Liu, Gao Zhang, Clemens Krepler, Chaoran Cheng, Zhi Wei, Rajasekharan Somasundaram, Giorgos Karakousis, Wei Xu, Jennifer JD Morrissette, Yiling Lu, Gordon B Mills, Ryan J Sullivan, Miao Benchun, Dennie T Frederick, Genevieve Boland, Keith T Flaherty, Ashani T Weeraratna, Meenhard Herlyn, Ravi Amaravadi, Lynn M Schuchter, Christin E Burd, Andrew E Aplin, Xiaowei Xu, Jessie Villanueva
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 5, Pp n/a-n/a (2018)
Abstract Despite novel therapies for melanoma, drug resistance remains a significant hurdle to achieving optimal responses. NRAS‐mutant melanoma is an archetype of therapeutic challenges in the field, which we used to test drug combinations to aver
Externí odkaz:
https://doaj.org/article/427671eabd2f438dbb2812ca02f929e3
Autor:
Zixing Wang, Kwok-Shing Ng, Tenghui Chen, Tae-Beom Kim, Fang Wang, Kenna Shaw, Kenneth L Scott, Funda Meric-Bernstam, Gordon B Mills, Ken Chen
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196939 (2018)
Identification of cancer driver mutations is critical for advancing cancer research and personalized medicine. Due to inter-tumor genetic heterogeneity, many driver mutations occur at low frequencies, which make it challenging to distinguish them fro
Externí odkaz:
https://doaj.org/article/b3bb9085ced6439eb6103ea2d8e82eab
Autor:
Garrett W Rhyasen, Yi Yao, Jingwen Zhang, Austin Dulak, Lillian Castriotta, Kelly Jacques, Wei Zhao, Farzin Gharahdaghi, Maureen M Hattersley, Paul D Lyne, Edwin Clark, Michael Zinda, Stephen E Fawell, Gordon B Mills, Huawei Chen
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200826 (2018)
BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes to acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent BRD4 gene amplifications. Despite previously de
Externí odkaz:
https://doaj.org/article/8462634de4fc494185365ef6a8d1e6ce
Autor:
James E Korkola, Eric A Collisson, Laura M Heiser, Chris Oates, Nora Bayani, Sleiman Itani, Amanda Esch, Wallace Thompson, Obi L Griffith, Nicholas J Wang, Wen-Lin Kuo, Brian Cooper, Jessica Billig, Safiyyah Ziyad, Jenny L Hung, Lakshmi Jakkula, Heidi Feiler, Yiling Lu, Gordon B Mills, Paul T Spellman, Claire Tomlin, Sach Mukherjee, Joe W Gray
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186551 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0133219.].
Externí odkaz:
https://doaj.org/article/f64d8adeba2f456294eef1b1123c9d8c
Autor:
Sharjeel H Sabir, Savitri Krishnamurthy, Sanjay Gupta, Gordon B Mills, Wei Wei, Andrea C Cortes, Kenna R Mills Shaw, Rajyalakshmi Luthra, Michael J Wallace
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189651 (2017)
Determine the characteristics of percutaneous core biopsies that are adequate for a next generation sequencing (NGS) genomic panel.All patients undergoing percutaneous core biopsies in interventional radiology (IR) with samples evaluated for a 46-gen
Externí odkaz:
https://doaj.org/article/a07a39409dc143faa2d14b7e3f5a7861