Výsledky vyhledávání - "Gordon B, Cutler"

Akademický článek

Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche

Autor: Diana Ponce, Fernando Rodríguez, José P. Miranda, Alexandra M. Binder, José L. Santos, Karin B. Michels, Gordon B. Cutler, Ana Pereira, Germán Iñiguez, Verónica Mericq

Publikováno v: Epigenetics, Vol 18, Iss 1 (2023)

Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyperinsulinemia, dyslipidemia, and polycystic ovary syndrome.

Externí odkaz: https://doaj.org/article/7428a6c1936f4beaa926de779c9b4405

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Akademický článek

Screening a large pediatric cohort with GH deficiency for mutations in genes regulating pituitary development and GH secretion: Frequencies, phenotypes and growth outcomesResearch in context

Autor: Werner F. Blum, Jürgen Klammt, Serge Amselem, Heike M. Pfäffle, Marie Legendre, Marie-Laure Sobrier, Marie-Pierre Luton, Christopher J. Child, Christine Jones, Alan G. Zimmermann, Charmian A. Quigley, Gordon B. Cutler, Jr, Cheri L. Deal, Jan Lebl, Ron G. Rosenfeld, John S. Parks, Roland W. Pfäffle

Publikováno v: EBioMedicine, Vol 36, Iss , Pp 390-400 (2018)

Background: Pituitary development and GH secretion are orchestrated by multiple genes including GH1, GHRHR, GLI2, HESX1, LHX3, LHX4, PROP1, POU1F1, and SOX3. We aimed to assess their mutation frequency and clinical relevance in children with severe G

Externí odkaz: https://doaj.org/article/eb38d45a2af84fb1a420e9f01ae4ca4c

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Genome-Wide Association Study and Polygenic Risk Scores of Serum DHEAS Levels in a Chilean Children Cohort

Autor: Ana Pereira, José P. Miranda, Verónica Mericq, José Luis Santos, Gordon B. Cutler, Camila Corvalán, Fernando Rodríguez, María Cecilia Lardone

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 107:e1727-e1738

Context Adrenarche reflects the developmental growth of the adrenal zona reticularis, which produces increasing adrenal androgen secretion (eg, dehydroepiandrosterone [DHEA]/dehydroepiandrosterone sulfate [DHEAS]) from approximately age 5 to 15 years

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e797ee1b12702df09b7a6ea1f42680
https://doi.org/10.1210/clinem/dgab814

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High DHEAS in girls and metabolic features throughout pubertal maturation

Autor: Ana Pereira, Paulina M. Merino, Jose L. Santos, German Iñiguez, Gordon B. Cutler, Camila Corvalan, Veronica Mericq

Publikováno v: Clinical endocrinologyREFERENCES. 96(3)

An association between premature adrenarche and metabolic syndrome at presentation has been described. Our aim was to assess whether the presence of high dehydroepiandrosterone sulphate (DHEAS [HD]) at the adrenarche determines the risk of metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7717948df3048b7cbdf8437ba6c21a61
https://pubmed.ncbi.nlm.nih.gov/34904249

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Resolution of Abnormal Gonadotropin Secretion After Surgical Cure in Men With ACTH-Dependent Cushing Syndrome

Autor: Skand Shekhar, Lynnette K. Nieman, Joselyne Tessa Tonelu, Janet E. Hall, Gordon B. Cutler

Publikováno v: Journal of the Endocrine Society

Background: Hypothalamic-pituitary-gonadal (HPG) dysfunction is known to occur in male patients with Cushing Syndrome (CS) but the underlying mechanisms of HPG dysfunction remain unclear. We performed frequent blood sampling and GnRH stimulation test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d0470635015332cdc010018d9f69e4
https://doi.org/10.1210/jendso/bvab048.1292

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Therapy with PTH 1–34 or calcitriol and calcium in diverse etiologies of hypoparathyroidism over 27 years at a single tertiary care center

Autor: Bo Zhang, Michail S. Lionakis, Gordon B. Cutler, Monica M. Schmitt, Elise M. N. Ferré, Shangyuan Ye, Karen K. Winer

Publikováno v: Bone. 149:115977

Objective Hypoparathyroidism has heterogeneous genetic and acquired etiologies with a broad spectrum of severity. Herein we describe the clinical outcomes of the largest cohort of hypoparathyroid patients reported to date, who were followed over 27-y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3c73b67466879d160913df961286d1
https://doi.org/10.1016/j.bone.2021.115977

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Development of additional pituitary hormone deficiencies in pediatric patients originally diagnosed with isolated growth hormone deficiency due to organic causes

Autor: Cheri Deal, Charmian A. Quigley, Ron G. Rosenfeld, Alan G. Zimmermann, Gordon B. Cutler, Werner F. Blum, Christopher J. Child, Stenvert L. S. Drop

Publikováno v: European Journal of Endocrinology, 174(5), 669-679. Bioscientifica Ltd

ObjectiveTo determine characteristics of children initially diagnosed with isolated growth hormone deficiency (IGHD) of organic aetiology, who later developed multiple pituitary hormone deficiencies (MPHD).DesignData were analysed for 716 growth horm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb58f4743d14445c9a5c2e634ea6f62
https://doi.org/10.1530/eje-15-1203

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In Vivo and In Vitro Characterization of Basal Insulin Peglispro: A Novel Insulin Analog

Autor: John Michael Beals, Hui-Rong Qian, Steven D. Kahl, Xiaoping Ruan, Gordon B. Cutler, Andrew Mark Vick, Owens Rebecca Anne, Julie S. Moyers, Mark W. Farmen, M. Dodson Michael, Shun Li, Ryan John Hansen, Chen Zhang, Anja Koester

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 357:459-465

The aim of this research was to characterize the in vivo and in vitro properties of basal insulin peglispro (BIL), a new basal insulin, wherein insulin lispro was derivatized through the covalent and site-specific attachment of a 20-kDa polyethylene-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c2025f98992771961b7f38e68e34dd
https://doi.org/10.1124/jpet.115.231035

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Height Gain and Safety Outcomes in Growth Hormone-Treated Children with Idiopathic Short Stature: Experience from a Prospective Observational Study

Autor: Kupper A. Wintergerst, Werner F. Blum, Christopher J. Child, Judith L. Ross, Ron G. Rosenfeld, Wayne V. Moore, Charmian A. Quigley, Gordon B. Cutler

Publikováno v: Hormone research in paediatrics. 91(4)

Background/Objectives: Growth hormone (GH) treatment of idiopathic short stature (ISS) received US Food and Drug Administration approval in 2003. We assessed height gain and safety in 2,450 children with ISS treated with GH in US clinical practice. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f159927437cbada1107ee0178328fa
https://pubmed.ncbi.nlm.nih.gov/31185471

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