Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gordin, Zupkovitz"'
Autor:
Gordin Zupkovitz, Julijan Kabiljo, Michael Kothmayer, Katharina Schlick, Christian Schöfer, Sabine Lagger, Oliver Pusch
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Erosion of the epigenetic DNA methylation landscape is a widely recognized hallmark of aging. Emerging advances in high throughput sequencing techniques, in particular DNA methylation data analysis, have resulted in the establishment of precise human
Externí odkaz:
https://doaj.org/article/1ff5f76daab54cc8b316f2d69e3e5779
Publikováno v:
Gene expression patterns : GEP. 33
The founding member of the sirtuin family, yeast Sir2, was the first evolutionarily conserved gene to be identified as a regulator of longevity. Sirtuins constitute a protein family of metabolic sensors, translating changes in NAD + levels into adapt
Autor:
Gordin Zupkovitz, David Martin, Christian Schöfer, Oliver Pusch, Astrid Hagelkruys, Christian Seiser, Marianne Steiner, Sabine Lagger
Publikováno v:
Histochemistry and Cell Biology
Aging is associated with profound changes in the epigenome, resulting in alterations of gene expression, epigenetic landscape, and genome architecture. Class I Histone deacetylases (HDACs), consisting of HDAC1, HDAC2, HDAC3, and HDAC8, play a major r
Autor:
Klara Weipoltshammer, Luc Snyers, Marlene Almeder, Christian Schöfer, Anja Stoisser, Gordin Zupkovitz, Marianne Fliesser
Publikováno v:
Nucleus
Actively transcribed regions of the genome have been found enriched for the histone H3 variant H3.3. This variant is incorporated into nucleosomes throughout the cell cycle whereas the canonical isoforms are predominately deposited in association wit
Autor:
Gordin Zupkovitz, Ivan Bilic, Patrick Matthias, Lamia El-Housseiny, Martin Gaisberger, Roland Tschismarov, Martina Rembold, Yu Zhang, Arnulf Hartl, Nicole Boucheron, Christian Seiser, Reinhard Grausenburger, Michelle M. Epstein, Wilfried Ellmeier
Publikováno v:
The Journal of Immunology. 185:3489-3497
Chromatin modifications, such as reversible histone acetylation, play a key role in the regulation of T cell development and function. However, the role of individual histone deacetylases (HDACs) in T cells is less well understood. In this article, w
Autor:
Dominique Meunier, Georg Weitzer, Sabine Lagger, Susanna Chiocca, Fritz Propst, Gordin Zupkovitz, Gerda Egger, Silvia Senese, Jennifer Jurkin, Martina Rembold, Christian Seiser, Reinhard Grausenburger, Julia Tischler, Reinhard Brunmeir
Publikováno v:
Molecular and Cellular Biology. 30:1171-1181
Histone deacetylases (HDACs) are chromatin-modifying enzymes that are involved in the regulation of proliferation, differentiation and development. HDAC inhibitors induce cell cycle arrest, differentiation, or apoptosis in tumor cells and are therefo
Autor:
Thomas Decker, Susanna Chiocca, Gerda Egger, Gordin Zupkovitz, Reinhard Grausenburger, Christian Seiser, Iwona Sadzak, Katrin Ramsauer, Markus Posch, Julia Tischler, Norbert Schweifer
Publikováno v:
Molecular and Cellular Biology. 26:7913-7928
Histone deacetylases (HDACs) catalyze the removal of acetyl groups from core histones. Because of their capacity to induce local condensation of chromatin, HDACs are generally considered repressors of transcription. In this report, we analyzed the ro
Publikováno v:
Journal of Biological Chemistry. 279:18046-18053
Prolonging the circulatory half-life of low mass protein drugs can be achieved either by administration of a pro-drug or through co-injection with a carrier protein that will slowly release the active protein. The rate of release is concentration and
Autor:
Reinhard Grausenburger, Sabine Lagger, Gordin Zupkovitz, Christian Seiser, Astrid Hagelkruys, Jennifer Jurkin, Lukas Kenner
Publikováno v:
Cell cycle (Georgetown, Tex.). 10(3)
Histone deacetylases (HDACs) are negative regulators of gene expression and have been implicated in tumorigenesis and tumor progression. Therefore, HDACs are promising targets for anti-tumor drugs. However, the relevant isoforms of the 18 members enc
Autor:
Stefan Winter, Christian Seiser, Elisabeth Simboeck, Susanna Chiocca, Luciano Di Croce, Franck Dequiedt, Silvia Senese, Egon Ogris, Gordin Zupkovitz, Anna Sawicka
Histone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are, therefore, promising anti-cancer drugs. The cyclin-dependent kinase inhibitor p21 is activated in histone deacetylase (HDAC) inhibitor-treated tumor cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a89d2c89128351e459a91c1a5abcaf
https://europepmc.org/articles/PMC3003405/
https://europepmc.org/articles/PMC3003405/