Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases

Autor: Sui, Yang, Qi, Lei, Zhang, Ke, Saini, Natalie, Klimczak, Leszek J., Sakofsky, Cynthia J., Gordenin, Dmitry A., Petes, Thomas D., Zheng, Dao-Qiong

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2020 Apr . 117(17), 9440-9450.

Externí odkaz: https://www.jstor.org/stable/26929950

Chromosomal Site-Specific Double-Strand Breaks Are Efficiently Targeted for Repair by Oligonucleotides in Yeast

Autor: Storici, Francesca, Durham, Christopher L., Gordenin, Dmitry A., Resnick, Michael A.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2003 Dec 01. 100(25), 14994-14999.

Externí odkaz: https://www.jstor.org/stable/3148549

Mutator Phenotypes of Yeast Strains Heterozygous for Mutations in the MSH2 Gene

Autor: Drotschmann, Karin, Clark, Alan B., Tran, Hiep T., Resnick, Michael A., Gordenin, Dmitry A., Kunkel, Thomas A.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1999 Mar . 96(6), 2970-2975.

Externí odkaz: https://www.jstor.org/stable/47473

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

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Nicholas, van Deurzen, Carolien HM, van de Vijver, Marc J, Veer, L van’t, von Mering, Christian

In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-C

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Integrative pathway enrichment analysis of multivariate omics data

Autor: Paczkowska, Marta, Barenboim, Jonathan, Sintupisut, Nardnisa, Fox, Natalie S, Zhu, Helen, Abd-Rabbo, Diala, Mee, Miles W, Boutros, Paul C, Abascal, Federico, Amin, Samirkumar B, Bader, Gary D, Beroukhim, Rameen, Bertl, Johanna, Boroevich, Keith A, Brunak, Søren, Campbell, Peter J, Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Chen, Ken, Choi, Jung Kyoon, Deu-Pons, Jordi, Dhingra, Priyanka, Diamanti, Klev, Feuerbach, Lars, Fink, J Lynn, Fonseca, Nuno A, Frigola, Joan, Gambacorti-Passerini, Carlo, Garsed, Dale W, Gerstein, Mark, Getz, Gad, Gonzalez-Perez, Abel, Guo, Qianyun, Gut, Ivo G, Haan, David, Hamilton, Mark P, Haradhvala, Nicholas J, Harmanci, Arif O, Helmy, Mohamed, Herrmann, Carl, Hess, Julian M, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Hornshøj, Henrik, Isaev, Keren, Izarzugaza, Jose MG, Johnson, Rory, Johnson, Todd A, Juul, Malene, Juul, Randi Istrup, Kahles, Andre, Kahraman, Abdullah, Kellis, Manolis, Khurana, Ekta, Kim, Jaegil, Kim, Jong K, Kim, Youngwook, Komorowski, Jan, Korbel, Jan O, Kumar, Sushant, Lanzós, Andrés, Lawrence, Michael S, Lee, Donghoon, Lehmann, Kjong-Van, Li, Shantao, Li, Xiaotong, Lin, Ziao, Liu, Eric Minwei, Lochovsky, Lucas, Lou, Shaoke, Madsen, Tobias, Marchal, Kathleen, Martincorena, Iñigo, Martinez-Fundichely, Alexander, Maruvka, Yosef E, McGillivray, Patrick D, Meyerson, William, Muiños, Ferran, Mularoni, Loris, Nakagawa, Hidewaki, Nielsen, Morten Muhlig, Park, Keunchil, Park, Kiejung, Pedersen, Jakob Skou, Pich, Oriol, Pons, Tirso, Pulido-Tamayo, Sergio, Raphael, Benjamin J, Reyes-Salazar, Iker, Reyna, Matthew A, Rheinbay, Esther, Rubin, Mark A, Rubio-Perez, Carlota, Sabarinathan, Radhakrishnan, Sahinalp, S Cenk, Saksena, Gordon, Salichos, Leonidas, Sander, Chris, Schumacher, Steven E, Shackleton, Mark, Shapira, Ofer, Shen, Ciyue, Shrestha, Raunak, Shuai, Shimin, Sidiropoulos, Nikos, Sieverling, Lina, Sinnott-Armstrong, Nasa, Stein, Lincoln D, Stuart, Joshua M, Tamborero, David, Tiao, Grace, Tsunoda, 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Vijver, Marc J, Veer, L van’t

Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discove

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