Valproate Targets Mammalian Gastrulation Impairing Neural Tissue Differentiation and Development of the Placental Source In Vitro

Autor: Ana Katušić-Bojanac, Milvija Plazibat, Marta Himelreich-Perić, Katarina Eck-Raković, Jure Krasić, Nino Sinčić, Gordana Jurić-Lekić, Davor Ježek, Floriana Bulić-Jakuš

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8861

The teratogenic activity of valproate (VPA), an antiepileptic and an inhibitor of histone deacetylase (HDACi), is dose-dependent in humans. Previous results showed that VPA impairs in vitro development and neural differentiation of the gastrulating e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94172e33185d6c105d2d22ab302ee8b

Extended Prophylactic Effect of N-tert-Butyl-α-phenylnitron against Oxidative/Nitrosative Damage Caused by the DNA-Hypomethylating Drug 5-Azacytidine in the Rat Placenta

Autor: Nikola Sobočan, Marta Himelreich-Perić, Ana Katušić-Bojanac, Jure Krasić, Nino Sinčić, Željka Majić, Gordana Jurić-Lekić, Ljiljana Šerman, Andreja Marić, Davor Ježek, Floriana Bulić-Jakuš

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 603
International Journal of Molecular Sciences, Vol 23, Iss 603, p 603 (2022)
International Journal of Molecular Sciences

Antioxidant N-tert-Butyl-α-phenylnitron (PBN) partly protected embryos from the negative effects of a DNA demethylating drug 5-azacytidine during pregnancy. Our aim was to investigate PBN’s impact on the placenta. Fischer rat dams were treated on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdb5992b1798da16989b4cf40783133

Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate

Autor: Mario Rašić, Ozren Gamulin, Jure Krasic, Nino Sinčić, Vedran Radonić, Floriana Bulić-Jakuš, Maria Krajačić, Marta Himerleich Perić, Gordana Jurić-Lekić, Maja Balarin, Ana Katušić Bojanac, Milvija Plazibat, Marko Škrabić

Publikováno v: The Febs Journal

Antiepileptic/teratogen valproate (VPA) is a histone deacetylase inhibitor/epigenetic drug proposed for the antitumor therapy where it is generally crucial to target poorly or undifferentiated cells to prevent a recurrence. Transplanted rodent gastru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ade048c29521d6f9c4923c5bd41b7e2
https://www.bib.irb.hr/1057756

A free radical scavenger ameliorates teratogenic activity of a DNA hypomethylating hematological therapeutic

Autor: Floriana Bulić-Jakuš, Marta Himelreich-Perić, Ljiljana Šerman, Željka Majić, Nino Sinčić, Nikola Sobočan, Davor Ježek, Gordana Jurić-Lekić, Maja Vlahović, Ana Katušić Bojanac, Jure Krasic

Publikováno v: Stem Cells and Development

The spin-trap free radical scavenger N-tert-butyl- a-phenylnitron (PBN) ameliorated effects of several teratogens involving reactive oxygen species (ROS). We investigated for the first time whether PBN could ameliorate teratogenesis induced by a DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0848d2a9a93778d091e8f0c6735cb203
http://doi.org/10.1089/scd.2018.0194

Interscapular brown adipose tissue recruitment is hindered by a temperature environment of 33°C: uncoupling protein-1 underexpression is not associated with obesity development in rats

Autor: Gordana Jurić-Lekić, Dragutin Lončar, Ljiljana Bedrica

Publikováno v: Archives of Biological Sciences, Vol 70, Iss 3, Pp 567-579 (2018)

Paper description: In rat’s brown adipose tissue (BAT), cold environment recruits adipocytes, stimulates Uncoupling protein-1 (UCP-1) expression and development of specific, uncoupled mitochondria (UC-mitochondria). The authors showed that at therm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466e128061bc590b18eed15b90a2ca1e
https://doi.org/10.2298/abs17121501j