Výsledky vyhledávání - "Gordana Jovic"

Two-years Postradiotherapy Biopsies: Lessons from MRC RT01 Trial

Autor: Antoine, Kass-Iliyya, Gordana, Jovic, Claire, Murphy, Cyril, Fisher, Isabel, Syndikus, Chakiath, Jose, Christopher D, Scrase, John D, Graham, David, Nicol, Matthew R, Sydes, David, Dearnaley

Publikováno v: European Urology

Background The importance of 2-yr postradiotherapy prostate biopsy status remains uncertain. Objective To assess the value of 2 year post treatment biopsies in a randomised trial of radiotherapy dose escalation. Design, setting, and participants Betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6bc21a54832f4288e1d8e8f494568484
https://pubmed.ncbi.nlm.nih.gov/29307509

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Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial

Autor: David P, Dearnaley, Gordana, Jovic, Isabel, Syndikus, Vincent, Khoo, Richard A, Cowan, John D, Graham, Edwin G, Aird, David, Bottomley, Robert A, Huddart, Chakiath C, Jose, John H L, Matthews, Jeremy L, Millar, Claire, Murphy, J Martin, Russell, Christopher D, Scrase, Mahesh K B, Parmar, Matthew R, Sydes

Publikováno v: The Lancet. Oncology. 15(4)

The aim of this trial was to compare dose-escalated conformal radiotherapy with control-dose conformal radiotherapy in patients with localised prostate cancer. Preliminary findings reported after 5 years of follow-up showed that escalated-dose confor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d6cc52675f368ef09e0f2212902806a
https://pubmed.ncbi.nlm.nih.gov/25289413

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Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial

Autor: Karen Sanders, John Anderson, Mahesh K.B. Parmar, Charlene Green, John Dwyer, Claire Amos, Malcolm David Mason, George N. Thalmann, Alastair W. S. Ritchie, Johann S. de Bono, J. Martin Russell, Gordana Jovic, Matthew R. Sydes, Nicholas D. James, David P. Dearnaley, Noel W. Clarke

Publikováno v: Trials, Vol 13, Iss 1, p 168 (2012)
Trials

Background Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) is a randomized controlled trial that follows a novel multi-arm, multi-stage (MAMS) design. We describe methodological and practical issues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a91cd3552bca8edcb5dab7a7bc2fab9
http://www.trialsjournal.com/content/13/1/168

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An exact method for analysis following a two-stage phase II cancer clinical trial

Autor: John Whitehead, Gordana Jovic

Publikováno v: Statistics in medicine. 29(30)

This paper presents an exact method for the analysis of a phase II cancer clinical trial conducted using a two-stage design in which early stopping may be allowed for either futility or efficacy. The method provides a point and interval estimate of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4ec336fa906187e7a5a0ed1c9f95c7
https://pubmed.ncbi.nlm.nih.gov/21170906

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A prognostic model based on nodal status and Ki-67 predicts the risk of recurrence and death in breast cancer patients with residual disease after preoperative chemotherapy

Autor: Antonio Frassoldati, Antonino Maiorana, Federico Piacentini, S. Giovannelli, Guido Ficarra, Valentina Guarneri, Roberto D'Amico, Pierfranco Conte, Gordana Jovic

Background: Preoperative chemotherapy (PCT) allows for in vivo testing of treatment effects on tumor and its microenvironment. Aim of this analysis was to evaluate the effect of PCT on tumor biomarker expression and to evaluate the prognostic role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f2e6f06adc9a08ef54247f7ed28fee
http://hdl.handle.net/11577/2554087

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Comparison of HER-2 and hormone receptor expression in primary breast cancers and asynchronous paired metastases: impact on patient management

Autor: Maria Vittoria Dieci, Antonino Maiorana, Gordana Jovic, S. Giovannelli, Guido Ficarra, Roberto D'Amico, Federico Piacentini, Valentina Guarneri, Pierfranco Conte, Elena Barbieri, Stefania Bettelli

Introduction. The assessment of hormone receptors (HRs) and human epidermal growth factor receptor (HER)-2 is necessary to select patients who are candidates for hormonal and anti–HER-2 therapy. The evaluation of these parameters is generally carri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8dae03ece8383231d3844e961bbb27c
http://hdl.handle.net/11577/2554212

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Letrozole Versus Letrozole Plus Lapatinib (GW572016) in Hormone-Sensitive, HER2-Negative Operable Breast Cancer: A Double-Blind, Randomized Phase II Study with Biomarker Evaluation (EGF109077-LAP107692/LETLOB)

Autor: Pierfranco Conte, Antonio Frassoldati, Valentina Guarneri, Federico Piacentini, S. Giovannelli, Cristina Oliva, Gordana Jovic

Many hormone receptor-positive tumors show primary or acquired resistance, possibly because of a crosstalk with other growth factor-related transduction pathways (mainly epidermal growth factor receptor family related). The LETLOB study is a European

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f51de8f917bb9cd9387d0bfc5c4cf6
https://hdl.handle.net/11380/613054

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