Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Goran Stjepanovic"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract AMBRA1 is a tumor suppressor protein that functions as a substrate receptor of the ubiquitin conjugation system with roles in autophagy and the cell cycle regulatory network. The intrinsic disorder of AMBRA1 has thus far precluded its struct
Externí odkaz:
https://doaj.org/article/a97541d84e6b443bbbc43d2058a0bce3
Autor:
Yun Nan Hou, Yang Cai, Wan Hua Li, Wei Ming He, Zhi Ying Zhao, Wen Jie Zhu, Qiang Wang, Xinyi Mai, Jun Liu, Hon Cheung Lee, Goran Stjepanovic, Hongmin Zhang, Yong Juan Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
SARM1 is a key player in axon degeneration. Here, the authors generate a nanobody, which specifically recognizes the NMN-bound state of SARM1 and helps resolve the SARM1 structure in an intermediate state of activation.
Externí odkaz:
https://doaj.org/article/7ac80b9e728148edbeca55b6a3fc6886
Autor:
N. Helge Meyer, Claudia Corbo, Guillermo R. Castro, Goran Stjepanovic, Giada G. Genchi, Valerio Marino
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/36c21b2328ae40419cc71f12b32b49d4
Autor:
Brooke M. Gardner, Dominic T. Castanzo, Saikat Chowdhury, Goran Stjepanovic, Matthew S. Stefely, James H. Hurley, Gabriel C. Lander, Andreas Martin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Pex1 and Pex6 form a heterohexameric Type-2 AAA-ATPase motor whose function in peroxisomal matrix-protein import is still debated. Here, the authors combine structural, biochemical, and cell-biological approaches to show that Pex1/Pex6 is a protein u
Externí odkaz:
https://doaj.org/article/4061a2c4972642c8b618677d741846cd
Autor:
Shiqian Qi, Zichong Li, Ursula Schulze-Gahmen, Goran Stjepanovic, Qiang Zhou, James H. Hurley
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The host super elongation complex (SEC) is hijacked by HIV-1 for viral transcription. Here the authors present the structure of RNA polymerase elongation factor ELL2 bound to the intrinsically disordered scaffold protein AFF4, identifying an ELL2 sur
Externí odkaz:
https://doaj.org/article/e30f66ef897f4bb8982ba67f0e094f26
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
The class III PI 3-kinase, VPS34 forms distinct complexes essential for cargo sorting and membrane trafficking in endocytosis as well as for autophagosome nucleation and maturation. We used integrative structural biology approach to provide insights
Externí odkaz:
https://doaj.org/article/c7e48ecc886244c1905f53834cbac2f7
Autor:
Ursula Schulze-Gahmen, Ignacia Echeverria, Goran Stjepanovic, Yun Bai, Huasong Lu, Dina Schneidman-Duhovny, Jennifer A Doudna, Qiang Zhou, Andrej Sali, James H Hurley
Publikováno v:
eLife, Vol 5 (2016)
HIV-1 Tat hijacks the human superelongation complex (SEC) to promote proviral transcription. Here we report the 5.9 Å structure of HIV-1 TAR in complex with HIV-1 Tat and human AFF4, CDK9, and CycT1. The TAR central loop contacts the CycT1 Tat-TAR r
Externí odkaz:
https://doaj.org/article/31e1d27483494283b8b90982f215bc2a
Autor:
Sulochanadevi Baskaran, Lars-Anders Carlson, Goran Stjepanovic, Lindsey N Young, Do Jin Kim, Patricia Grob, Robin E Stanley, Eva Nogales, James H Hurley
Publikováno v:
eLife, Vol 3 (2014)
The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) that functions in early autophagy consists of the lipid kinase VPS34, the scaffolding protein VPS15, the tumor suppressor BECN1, and the autophagy-specific subunit ATG14. The structure
Externí odkaz:
https://doaj.org/article/878bfa6565584a0fa2c317242405c1e1
AMBRA1 is a tumor suppressor protein that functions as a substrate receptor of the ubiquitin conjugation system as part of autophagy and cell-cycle regulatory network. The highly intrinsic disorder of AMBRA1 has so far precluded its structural determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6571a7e8889d51c1327af96f45f0cdb2
https://doi.org/10.1101/2022.12.04.519012
https://doi.org/10.1101/2022.12.04.519012
Autor:
Livia Wilz Brier, Goran Stjepanovic, Ashley M. Thelen, Randy Schekman, Liang Ge, James H. Hurley
Publikováno v:
Molecular Biology of the Cell
Molecular biology of the cell, vol 30, iss 9
Molecular biology of the cell, vol 30, iss 9
Autophagy is a conserved eukaryotic pathway critical for cellular adaptation to changes in nutrition levels and stress. The class III phosphatidylinositol (PI)3-kinase complexes I and II (PI3KC3-C1 and -C2) are essential for autophagosome initiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556c11c5e2aa28d3b42dabfb82c6d458
https://doi.org/10.1091/mbc.e18-11-0743
https://doi.org/10.1091/mbc.e18-11-0743