Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Goran Söhl"'
Autor:
Xi Erick Lin, Goran Söhl, Wenxue Tang, Jill Hibshman, Klaus Willecke, Shoeb Ahmad, Ping Helen Chen, Yuhua Li, Yan Qu, Qing Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 104:1337-1341
Mutations in genes coding for connexin26 (Cx26) and/or Cx30 are linked to approximately half of all cases of human autosomal nonsyndromic prelingual deafness. Cx26 and Cx30 are the two major Cx isoforms found in the cochlea, and they coassemble to fo
Autor:
Wenxue Tang, Dalian Ding, Xi Erick Lin, Richard Salvi, Goran Söhl, Yan Qu, Ping Chen, Ian Dahlke, Klaus Willecke
Publikováno v:
The Journal of Comparative Neurology. 504:499-507
Mutations in connexin (Cx) genes are responsible for a large proportion of human inherited prelingual deafness cases. The most commonly found human Cx mutations are either Cx26 or Cx30 deletions. Histological observations made in the organ of Corti o
Autor:
Thorsten Höher, Stephanie Urschel, Reto Weiler, Timm Schubert, Goran Söhl, Rolf Dermietzel, Klaus Willecke, Philipp Wörsdörfer, Takayuki Asahara, Cantas Alev
Publikováno v:
Journal of Biological Chemistry. 281:33163-33171
Gap junctions in AII amacrine cells of mammalian retina participate in the coordination of the rod and cone signaling pathway involved in visual adaptation. Upon stimulation by light, released dopamine binds to D(1) receptors on AII amacrine cells le
Autor:
Martin Güldenagel, Dorothée Caille, Claes B. Wollheim, Jean-Claude Henquin, Paolo Meda, Klaus Willecke, Asllan Gjinovci, Magalie A. Ravier, Anne Charollais, Goran Söhl
Publikováno v:
Diabetes. 54:1798-1807
Normal insulin secretion requires the coordinated functioning of beta-cells within pancreatic islets. This coordination depends on a communications network that involves the interaction of beta-cells with extracellular signals and neighboring cells.
Publikováno v:
Trends in Neurosciences. 28:188-195
Recent research results indicate that glial gap-junction communication is much more complex and widespread than originally thought, and has diverse roles in brain homeostasis and the response of the brain to injury. The situation is far from clear, h
Autor:
Chris I. De Zeeuw, Klaus Willecke, Joachim Degen, Carola Meier, Rolf Dermietzel, Stephanie Urschel, Goran Söhl, Elisabeth Petrasch-Parwez, Ruben S. Van Der Giessen, Karl Schilling
Publikováno v:
Journal of Comparative Neurology. 473:511-525
Targeted deletion of the connexin36 (Cx36) gene in the mouse genome leads to visual transmission defects, weakened synchrony of rhythmic inhibitory potentials in the neocortex, and disruption of -frequency network oscillations. We have generated tran
Autor:
Barbara Teubner, Maria A. de Souza Silva, Joseph P. Huston, Goran Söhl, Martin Theis, Katerina Namestkova, KIaus Willecke, Ekrem Dere, Christian Frisch
Publikováno v:
European Journal of Neuroscience. 18:2313-2318
Gap junctions mediate communication between many cell types in the brain. Gap junction channels are composed of membrane-spanning connexin (Cx) proteins, allowing the cell-to-cell passage of small ions and metabolites. Cx43 is the main constituent of
Publikováno v:
Cell Communication & Adhesion. 10:413-417
The role of astrocytic gap junctions in ischemia remains controversial. Several studies support that astrocytic gap junctions play a role in the spread of hypoxic injury, while other reports have demonstrated that blocking astrocytic gap junctions in
Publikováno v:
European Journal of Neuroscience. 18:267-274
Previous immunofluorescence analyses in mice and rats showed a mainly astrocytic expression of the gap junction protein connexin43 (Cx43) in brain. However, in situ hybridization of murine brain sections suggested strong expression of Cx43 mRNA in hi
Autor:
Edilzh Chorev, Yosi Yarom, Marcel T. G. de Jeu, Chris I. De Zeeuw, Martin Gueldenagel, Dick Jaarsma, Klaus Willecke, Tom J. H. Ruigrok, Rolf Dermietzel, Anna Devor, Yait Manor, Ruben S. Van Der Giessen, Casper C. Hoogenraad, Carola Meier, J. Bijman, Elisabeth Petrasch-Parwez, Werner M. Kistler, Goran Söhl, Pim J. French
Publikováno v:
The Journal of Neuroscience. 23:4700-4711
Compensatory mechanisms after genetic manipulations have been documented extensively for the nervous system. In many cases, these mechanisms involve genetic regulation at the transcription or expression level of existing isoforms. We report a novel m