Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Goran Landek"'
Autor:
Andrew D. Cansfield, Mark A. Ator, Joydeep Banerjee, Michael Bestwick, Andrea Bortolato, Giles A. Brown, Jason Brown, Kristina Butkovic, Julie E. Cansfield, John A. Christopher, Miles Congreve, Gabriella Cseke, Francesca Deflorian, Benjamin Dugan, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Goran Landek, Jonathan Mason, Alistair O’Brien, Gregory R. Ott, Renata Rupcic, Gordon Saxty, Stacey M. Southall, Rahela Zadravec, Stephen P. Watson
Publikováno v:
ACS Chemical Neuroscience. 13:751-765
A series of macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonists identified using structure-based design principles, exemplified by HTL0028016 (1) and HTL0028125 (2), is described. Structural characterization by X-ray crystallograp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c446db762c3a729f140cd365a9977f1b
https://doi.org/10.1021/acschemneuro.1c00696
https://doi.org/10.1021/acschemneuro.1c00696
Autor:
Radan Spaventi, Santiago Ferrer, Sulejman Alihodžić, Goran Landek, Kristina Starčević, Esperanza Herreros, Ana Toplak, Dijana Pesic, Mihaela Perić
Publikováno v:
European Journal of Medicinal Chemistry. 49:365-378
Malaria remains the most prevalent tropical disease, and due to the spread of resistant parasites novel therapeutics are urgently needed. Azithromycin has shown potential in malaria treatment so we designed hybrid azalide molecules with the aim to im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac3d84ea1432960e02ac8734f711de5
https://doi.org/10.1016/j.ejmech.2012.01.039
https://doi.org/10.1016/j.ejmech.2012.01.039
Autor:
Mihaela Perić, Wilbur K. Milhous, Nedjeljko Kujundžić, Jasna Padovan, Zrinka Ivezić Schönfeld, Andrea Fajdetić, Kirsten S. Smith, Dubravko Jelić, Colin Ohrt, Wolfgang Schönfeld, William Y. Ellis, Arba L. Ager, Radan Spaventi, Dinko Žiher, Mirjana Bukvić Krajačić, Goran Landek
Publikováno v:
Journal of Medicinal Chemistry. 54:3595-3605
Azithromycin, a first member of the azalide family of macrolides, while having substantial antimalarial activity, failed as a single agent for malaria prophylaxis. In this paper we present the first analogue campaign to identify more potent compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df5e76ffd438c5a97f113e26e8c837c
https://doi.org/10.1021/jm2001585
https://doi.org/10.1021/jm2001585
Publikováno v:
Chromatographia. 64:469-473
1,1′-Binaphthyl-2,2′-diol (BINOL) was analysed on three different chiral stationary phases comprising 3,5-dinitrobenzoyl-l-leucine as chiral selector. Chromatographic data were related to NMR measurements performed for the mixture of the soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec49e2ef1fa7162288b1b2ed21380a21
https://doi.org/10.1365/s10337-006-0041-5
https://doi.org/10.1365/s10337-006-0041-5
The dynamic properties of planar chiral 1-hydroxymethyl-substituted dibenzo[b,f]thieno[3,4-d]-fused oxepine and thiepine derivatives have been investigated by use of variable-temperature nuclear magnetic resonance spectroscopy combined with line-shap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec96cda69a7e31e9c14b42ce5106c608
https://www.bib.irb.hr/1103598
https://www.bib.irb.hr/1103598
Autor:
Kristina Starčević, Esperanza Herreros, Radan Spaventi, Santiago Ferrer, Mihaela Perić, Goran Landek, Sulejman Alihodzic, Ana Toplak, Dijana Pesic
Publikováno v:
ChemInform. 43
Novel hybrid molecules comprising 4-aminoquinoline moiety covalently linked to 15-membered azalide scaffold at position C-3′ are synthesized and biologically evaluated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::072a13919d06b559275b638a32add807
https://doi.org/10.1002/chin.201230222
https://doi.org/10.1002/chin.201230222
Autor:
Andrea Fajdetić, Dubravko Jelić, Mirjana Bukvić Krajačić, Jasna Padovan, Sulejman Alihodžić, Arba L. Ager, Wilbur K. Milhous, Kirsten S. Smith, Milan Mesic, Dinko Žiher, Radan Spaventi, Antun Hutinec, William Y. Ellis, Mihaela Perić, Goran Landek, Zrinka Ivezić-Schönfeld, Renata Rupčić, Colin Ohrt
Publikováno v:
Journal of medicinal chemistry. 55(3)
Novel classes of antimalarial drugs are needed due to emerging drug resistance. Azithromycin, the first macrolide investigated for malaria treatment and prophylaxis, failed as a single agent and thus novel analogues were envisaged as the next generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e89530ff62b7a8631590f61d1dc18d3
https://pubmed.ncbi.nlm.nih.gov/22148880
https://pubmed.ncbi.nlm.nih.gov/22148880
Publikováno v:
ChemInform. 42
A range of enantiopure aryl allylamines is prepared by optical resolution with Novozym 435.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd64407c42b5bcc109335a5387d0e142
https://doi.org/10.1002/chin.201152056
https://doi.org/10.1002/chin.201152056
A range of 1-aryl-allylamines were prepared in moderate to excellent enantioselectivity (ee 63.5%→99.9%) using lipase B from a Candida antarctica catalyzed resolution of racemic amines. This is the first time that CaLB has been used for the resolut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922114d5409761e9bb2850f6c9e9ad8f
https://doi.org/10.1016/j.tetasy.2011.06.004
https://doi.org/10.1016/j.tetasy.2011.06.004
Publikováno v:
Tetrahedron: Asymmetry. 22:1594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a10a176ee615977238ace6773f817c8
https://doi.org/10.1016/j.tetasy.2011.09.001
https://doi.org/10.1016/j.tetasy.2011.09.001