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Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase.

Autor: Pau Jané, Gergő Gógl, Camille Kostmann, Goran Bich, Virginie Girault, Célia Caillet-Saguy, Pascal Eberling, Renaud Vincentelli, Nicolas Wolff, Gilles Travé, Yves Nominé

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0244613 (2020)

Protein domains often recognize short linear protein motifs composed of a core conserved consensus sequence surrounded by less critical, modulatory positions. PTEN, a lipid phosphatase involved in phosphatidylinositol 3-kinase (PI3K) pathway, contain

Externí odkaz: https://doaj.org/article/7bab4add76df4cae8c81a28d0fb5edf1

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ProFeatMap: a highly customizable tool for 2D feature representation of protein sets

Autor: Goran Bich, Elodie Monsellier, Gilles Travé, Yves Nominé

Publikováno v: Bioinformatics Advances. 3

Motivation Studies of sets of proteins are a central point in biology. In particular, the application of omics in the last decades has generated lists of several hundreds or thousands of proteins or genes. However, these lists are often not inspected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::078b10cedcd31d80c8e32a35a99c4fa0
https://doi.org/10.1093/bioadv/vbad022

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A Computational Protocol to Analyze PDZ/PBM Affinity Data Obtained by High-Throughput Holdup Assay

Autor: Yves Nominé, Gilles Travé, Lionel Chiron, Goran Bich, Pau Jane

Publikováno v: PDZ Mediated Interactions
PDZ Mediated Interactions, 2256, Springer US, pp.61-74, 2021, Methods in Molecular Biology, ⟨10.1007/978-1-0716-1166-1_4⟩
Methods in Molecular Biology ISBN: 9781071611654

The holdup assay is an automated high-throughput comparative chromatographic retention approach that allows to measure quantitative binding intensities (BI) for a large number of domain-motif pairs and deduce equilibrium binding affinity constants. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f21a2c41d72bb7b3db778900f0eadbd
https://hal.archives-ouvertes.fr/hal-03406173

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A Computational Protocol to Analyze PDZ/PBM Affinity Data Obtained by High-Throughput Holdup Assay

Autor: Pau, Jané, Lionel, Chiron, Goran, Bich, Gilles, Travé, Yves, Nominé

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2256

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c474805e16d27f8fff62bd2d96476f8e
https://pubmed.ncbi.nlm.nih.gov/34014516

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Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase

Autor: Yves Nominé, Virginie Girault, Célia Caillet-Saguy, Nicolas Wolff, Renaud Vincentelli, Goran Bich, Gilles Travé, Gergő Gógl, Camille Kostmann, Pascal Eberling, Pau Jane

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2020, 15 (12), pp.e0244613. ⟨10.1371/journal.pone.0244613⟩
PLoS ONE, 2020, 15 (12), pp.e0244613. ⟨10.1371/journal.pone.0244613⟩
PLoS ONE, Vol 15, Iss 12, p e0244613 (2020)

International audience; Protein domains often recognize short linear protein motifs composed of a core conserved consensus sequence surrounded by less critical, modulatory positions. PTEN, a lipid phosphatase involved in phosphatidylinositol 3-kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7eeb75649b819ef18e1dc11403dd703
https://hal.archives-ouvertes.fr/hal-03099990

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Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study

Autor: Camille Kostmann, Gergo Gogl, Renaud Vincentelli, Nikolai N. Sluchanko, Célia Caillet-Saguy, Goran Bich, Nicolas Wolff, László Nyitray, Yves Nominé, Gilles Travé, Pau Jane, Alexandra Cousido-Siah

Publikováno v: Structure
Structure, 2020, 28 (7), pp.747. ⟨10.1016/j.str.2020.03.010⟩
Structure, Elsevier (Cell Press), 2020, ⟨10.1016/j.str.2020.03.010⟩

International audience; Protein-protein interaction motifs are often alterable by post-translational modifications. For example, 19% of predicted human PDZ domain-binding motifs (PBMs) have been experimentally proven to be phosphorylated, and up to 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd03d011e663acf98c2a5544f37e1fb
https://hal.science/hal-02545805/document

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