Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Goragot, Wisedchaisri"'
Autor:
Lige Tonggu, Goragot Wisedchaisri, Tamer M. Gamal El-Din, Michael J. Lenaeus, Matthew M. Logan, Tatsuya Toma, Justin Du Bois, Ning Zheng, William A. Catterall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The poison dart toxin batrachotoxin is exceptional for its high potency and toxicity, and for its multifaceted modification of the function of voltage-gated sodium channels. By using cryogenic electron microscopy, we identify two homologous,
Externí odkaz:
https://doaj.org/article/0cd0beb8ab5c4f2796f93d647ea54c87
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels. However, most of these dr
Externí odkaz:
https://doaj.org/article/d4d6528835cd4d61b3ff18b5c9b134f7
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Gain-of-function mutations in voltage-gated sodium channel Na V 1.7 cause severe inherited pain syndromes, including inherited erythromelalgia (IEM). The structural basis of these disease mutations, however, remains elusive. Here, we focused on three
Publikováno v:
Biophysical Journal. 122:102a
Voltage-gated sodium channels initiate action potentials in prokaryotes and in many eukaryotic cells, including vertebrate nerve and muscle. Their activation is steeply voltage-dependent, but it is unclear how the voltage sensitivity is set or whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fede69e7afded8878f1067a78b13352
https://doi.org/10.1101/2020.11.21.392571
https://doi.org/10.1101/2020.11.21.392571
Autor:
Goragot, Wisedchaisri, Lige, Tonggu, Tamer M, Gamal El-Din, Eedann, McCord, Ning, Zheng, William A, Catterall
Publikováno v:
Mol Cell
Voltage-gated sodium channels initiate electrical signals and are frequently targeted by deadly gating-modifier neurotoxins, including tarantula toxins, which trap the voltage sensor in its resting state. The structural basis for tarantula-toxin acti
Publikováno v:
Nat Chem Biol
Electrical signaling was a dramatic development in evolution, allowing complex single-cell organisms like Paramecium to coordinate movement and early metazoans like worms and jellyfish to send regulatory signals rapidly over increasing distances. But
Publikováno v:
Nature Chemical Biology. 13:455-463
Electrical signals generated by minute currents of ions moving across cell membranes are central to all rapid processes in biology. Initiation and propagation of electrical signals requires voltage-gated sodium (NaV) and calcium (CaV) channels. These
Autor:
Ning Zheng, Liguo Wang, E. McCord, Lige Tonggu, Goragot Wisedchaisri, Tamer M. Gamal El-Din, William A. Catterall
Publikováno v:
Cell
Trends Pharmacol Sci
Trends Pharmacol Sci
Voltage-gated sodium (Na(V)) channels initiate action potentials in nerve, muscle, and other electrically excitable cells. The structural basis of voltage gating is uncertain because the resting state exists only at deeply negative membrane potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98813f6f11e0436ef277afe32b177c3b
https://europepmc.org/articles/PMC6688928/
https://europepmc.org/articles/PMC6688928/
Autor:
Goragot Wisedchaisri, E. McCord, William A. Catterall, Tamer M. Gamal El-Din, Ning Zheng, Lige Tonggu
Publikováno v:
Molecular Cell. 81:38-48.e4
Voltage-gated sodium channels initiate electrical signals and are frequently targeted by deadly gating-modifier neurotoxins, including tarantula toxins, which trap the voltage sensor in its resting state. The structural basis for tarantula-toxin acti