Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gopireddy R, Reddy"'
Autor:
Victor A. Flores‐Tamez, Miguel Martín‐Aragón Baudel, Junyoung Hong, Jade L. Taylor, Lu Ren, Thanhmai Le, Arsalan U. Syed, Yumna Moustafa, Navid Singhrao, Wendy R. Lemus‐Martinez, Gopireddy R. Reddy, Victoria Ramer, Kwun Nok Mimi Man, Peter Bartels, Ye Chen‐Izu, Chao‐Yin Chen, Sergi Simo, Eamonn J. Dickson, Stefano Morotti, Eleonora Grandi, L. Fernando Santana, Johannes W. Hell, Mary C. Horne, Madeline Nieves‐Cintrón, Manuel F. Navedo
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 20 (2024)
Background Increased vascular CaV1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are unclear. We hypothe
Externí odkaz:
https://doaj.org/article/3442030d4e57470fb2eaf2e11402d37c
Autor:
Maria Paz Prada, Arsalan U. Syed, Gopireddy R. Reddy, Miguel Martín-Aragón Baudel, Víctor A. Flores-Tamez, Kent C. Sasse, Sean M. Ward, Padmini Sirish, Nipavan Chiamvimonvat, Peter Bartels, Eamonn J. Dickson, Johannes W. Hell, John D. Scott, Luis F. Santana, Yang K. Xiang, Manuel F. Navedo, Madeline Nieves-Cintrón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Molecular mechanisms by which glucose modulates L-type Ca2+ channel activity and vascular reactivity are unclear. Here the authors report a nanocomplex orchestrated by AKAP5 that facilitates local purinergic stimulation of L-type Ca2+ channels and va
Externí odkaz:
https://doaj.org/article/16c1bd62635d42608c4af12cd7cb45a7
Autor:
Gopireddy R. Reddy, Lu Ren, Phung N. Thai, Jessica L. Caldwell, Manuela Zaccolo, Julie Bossuyt, Crystal M. Ripplinger, Yang K. Xiang, Madeline Nieves-Cintrón, Nipavan Chiamvimonvat, Manuel F. Navedo
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103693- (2022)
Summary: Sinoatrial node (SAN) cells are the pacemakers of the heart. This study describes a method for culturing and infection of adult mouse SAN cells with FRET-based biosensors that can be exploited to examine signaling events. SAN cells cultured
Externí odkaz:
https://doaj.org/article/a4901bdc385443a6b47fa18fb6c488d0
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract β1-adrenergic receptors (β1ARs) mediate catecholamine actions in cardiomyocytes by coupling to both Gs/cAMP-dependent and Gs-independent/growth-regulatory pathways. Structural studies of the β1AR define ligand-binding sites in the transme
Externí odkaz:
https://doaj.org/article/dcbfc13e7f234e8282b710543fd712ef
Autor:
Toni M. West, Qingtong Wang, Bingqing Deng, Yu Zhang, Federica Barbagallo, Gopireddy R. Reddy, Dana Chen, Kyle S. Phan, Bing Xu, Andres Isidori, Yang K. Xiang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 15 (2019)
Background In murine heart failure models and in humans with diabetic‐related heart hypertrophy, inhibition of phosphodiesterase 5 (PDE5) by sildenafil improves cardiac outcomes. However, the mechanism by which sildenafil improves cardiac function
Externí odkaz:
https://doaj.org/article/d34a9d274eca41d78880e0fc91e29768
Autor:
Maria Paz Prada, Arsalan U Syed, Olivia R Buonarati, Gopireddy R Reddy, Matthew A Nystoriak, Debapriya Ghosh, Sergi Simó, Daisuke Sato, Kent C Sasse, Sean M Ward, Luis F Santana, Yang K Xiang, Johannes W Hell, Madeline Nieves-Cintrón, Manuel F Navedo
Publikováno v:
eLife, Vol 8 (2019)
Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a Gs-coupled P2Y receptor is an upstream activator of PKA med
Externí odkaz:
https://doaj.org/article/834ddbe5b2af4b2d9cbfe39b3182cbe7
Autor:
Bing, Xu, Minghui, Li, Ying, Wang, Meimi, Zhao, Stefano, Morotti, Qian, Shi, Qingtong, Wang, Federica, Barbagallo, Jian-Peng, Teoh, Gopireddy R, Reddy, Elizabeth F, Bayne, Yongming, Liu, Ao, Shen, Jose L, Puglisi, Ying, Ge, Ji, Li, Eleonora, Grandi, Madeline, Nieves-Cintron, Yang K, Xiang
Publikováno v:
Circ Res
RATIONALE: Cardiotoxic β(1) adrenergic receptor (β(1)AR)-CaMKII signaling is a major and critical feature associated with development of heart failure. Synapse-associated protein 97 (SAP97) is a multi-functional scaffold protein that binds directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4ba863eb0b70c6a7b5a9deb6d892662
https://pubmed.ncbi.nlm.nih.gov/32507058
https://pubmed.ncbi.nlm.nih.gov/32507058