Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gopinath S Palanisamy"'
Autor:
Gopinath S Palanisamy, Natalie M Kirk, David F Ackart, Andrés Obregón-Henao, Crystal A Shanley, Ian M Orme, Randall J Basaraba
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34148 (2012)
The typical host response to infection of humans and some animals by M. tuberculosis is the accumulation of reactive oxygen species generating inflammatory cells into discrete granulomas, which frequently develop central caseous necrosis. In previous
Externí odkaz:
https://doaj.org/article/70494065d5ad4bb6ad2dd0a766bce4e3
Autor:
Gopinath S Palanisamy, Natalie M Kirk, David F Ackart, Crystal A Shanley, Ian M Orme, Randall J Basaraba
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26254 (2011)
The development of granulomatous inflammation with caseous necrosis is an important but poorly understood manifestation of tuberculosis in humans and some animal models. In this study we measured the byproducts of oxidative stress in granulomatous le
Externí odkaz:
https://doaj.org/article/93f7bf8bdb5c42aa9219efda9820fa1e
Autor:
Alison D. Parisian, Gopinath S. Palanisamy, Fabian Ortega, Judevin L. Sapugay, William J. Bodell, David Kulp, Peter Kushner, Cyrus Harmon
Publikováno v:
Cancer Research. 83:P2-24
OP-1250, a complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD), is currently in Phase I/II clinical trials for the treatment of estrogen receptor positive (ER+)/human epidermal growth factor receptor 2 negati
Autor:
Alison D Parisian, Leslie Hodges-Gallagher, Richard Sun, Susanna Barratt, Gopinath S Palanisamy, Julia Lawrence, Pamela Klein, David C Myles, Cyrus L Harmon, Peter J Kushner
Publikováno v:
Cancer Research. 82:P5-08
The human epidermal growth factor receptor 2 (HER2, also known as ERBB2) oncogene is overexpressed in approximately 25% of breast cancer tumors and is associated with a high rate of brain metastasis. Patients with brain metastases have a poor prognos
Autor:
Yan Wu, Jean-Michel Vernes, Wei-Ching Liang, Karla Lancaster, Melissa Schutten, Y. Gloria Meng, Gopinath S. Palanisamy, Rutwij A. Dave, Matthew S Holdren, Adeyemi O Adedeji, Fiona Zhong, Mayur S. Mitra, Shannon J. Turley
Publikováno v:
Toxicological Sciences. 175:24-34
Transforming growth factor β (TGFβ) signaling has been recently shown to reduce antitumor response to PD-L1 blockade, leading to a renewed enthusiasm in developing anti-TGFβ therapies for potential combination with cancer immunotherapy agents. Inh
Autor:
Muriel Laine, Marianne E. Greene, Tiffany Leng, Sophia Li, Gopinath S. Palanisamy, Cyrus L. Harmon, Leslie Hodges-Gallagher, Peter J. Kushner, Geoffrey L. Greene
Publikováno v:
Cancer Research. 82:1618-1618
Estrogen receptor positive (ER+) breast cancers represent about 70-75% of all breast cancer. In general, these cancers are effectively treated with adjuvant endocrine therapies, with or without the addition of CDK4/6 inhibitors. However, many patient
Autor:
Edna F. Choo, Kevin DeMent, Jodie Pang, Dimitry M. Danilenko, Dolores Diaz, Arna Katewa, Dong U. Lee, Gopinath S. Palanisamy, Nico Ghilardi, Janice Corpuz, Paula Katavolos, Charly Sioson
Publikováno v:
Toxicology and Applied Pharmacology. 300:47-54
Bromo and extra terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are epigenetic transcriptional regulators required for efficient expression of growth promoting, cell cycle progression and antiapoptotic genes. Through their bromodomain, these prot
Autor:
Vinicius Carreira, Keith Nelson, Stacey Fossey, Lila Ramaiah, Kenneth A Schafer, Bevin Zimmerman, Erin Quist, Gopinath S. Palanisamy
Publikováno v:
Toxicologic pathology. 46(8)
The toxicologic pathologist plays a vital role in the scientific community, using their unique blend of diagnostic and investigative skills to advance biomedical research, public health, drug discovery, or regulatory practices. But what exactly do to
Autor:
Edward D. Chan, Marisa Harton, Gopinath S. Palanisamy, Marcela Henao Tamayo, Diane J. Ordway, Megan L. Caraway, Crystal A. Shanley, Ian M. Orme, Randall J. Basaraba, Shaobin Shang
Publikováno v:
Tuberculosis. 91:378-385
There is increasing evidence that clinical isolates of Mycobacterium tuberculosis that belong to the W-Beijing genotype of newly emerging strains are often of very high virulence when tested in small animal models, including the mouse and guinea pig.
Autor:
Marcela Henao-Tamayo, Diane J. Ordway, Ian M. Orme, Gopinath S. Palanisamy, Randall J. Basaraba, Erin E. Smith, Baolin Wang, Crystal A. Shanley
Publikováno v:
Clinical and Vaccine Immunology. 15:1248-1258
Mycobacterium bovis bacillus Calmette-Guérin (BCG) currently remains the only licensed vaccine for the prevention of tuberculosis. In this study, we used a newly described flow cytometric technique to monitor changes in cell populations accumulatin