Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Gopinath, Krishnamoorthy"'
Autor:
Julia Figl, Heike Köhler, Nadine Wedlich, Elisabeth M. Liebler-Tenorio, Leander Grode, Gerald Parzmair, Gopinath Krishnamoorthy, Natalie E. Nieuwenhuizen, Stefan H. E. Kaufmann, Christian Menge
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5509 (2023)
A more effective vaccine against tuberculosis than Bacille Calmette-Guérin (BCG) is urgently needed. BCG derived recombinant VPM1002 has been found to be more efficacious and safer than the parental strain in mice models. Newer candidates, such as V
Externí odkaz:
https://doaj.org/article/cf3c8e959991469b9381847405d774b7
Autor:
Barr, David A *, Lewis, Joseph M, Feasey, Nicholas, Schutz, Charlotte, Kerkhoff, Andrew D, Jacob, Shevin T, Andrews, Ben, Kelly, Paul, Lakhi, Shabir, Muchemwa, Levy, Bacha, Helio A, Hadad, David J, Bedell, Richard, van Lettow, Monique, Zachariah, Rony, Crump, John A, Alland, David, Corbett, Elizabeth L, Gopinath, Krishnamoorthy, Singh, Sarman, Griesel, Rulan, Maartens, Gary, Mendelson, Marc, Ward, Amy M, Parry, Christopher M, Talbot, Elizabeth A, Munseri, Patricia, Dorman, Susan E, Martinson, Neil, Shah, Maunank, Cain, Kevin, Heilig, Charles M, Varma, Jay K, von Gottberg, Anne, Sacks, Leonard, Wilson, Douglas, Squire, S Bertel, Lalloo, David G, Davies, Gerry, Meintjes, Graeme
Publikováno v:
In The Lancet Infectious Diseases June 2020 20(6):742-752
Autor:
Gopinath Krishnamoorthy, Peggy Kaiser, Patricia Constant, Ulrike Abu Abed, Monika Schmid, Christian K. Frese, Volker Brinkmann, Mamadou Daffé, Stefan H. E. Kaufmann
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Mycofactocin is a new class of peptide-derived redox cofactors present in a selected group of bacteria including Mycobacterium tuberculosis. Mycofactocin biosynthesis requires at least six genes, including mftD, encoding putative lactate deh
Externí odkaz:
https://doaj.org/article/6d1b9d18c5514c898bf4807ce058aaa7
Autor:
Elisabeth M. Liebler-Tenorio, Johannes Heyl, Nadine Wedlich, Julia Figl, Heike Köhler, Gopinath Krishnamoorthy, Natalie E. Nieuwenhuizen, Leander Grode, Stefan H. E. Kaufmann, Christian Menge
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 10992 (2022)
Tuberculous granulomas are highly dynamic structures reflecting the complex host–mycobacterium interactions. The objective of this study was to compare granuloma development at the site of vaccination with BCG and its recombinant derivatives in goa
Externí odkaz:
https://doaj.org/article/943155d9e3524ec2855306ffbe0934db
Autor:
Gopinath Krishnamoorthy, Peggy Kaiser, Ulrike Abu Abed, January Weiner, Pedro Moura-Alves, Volker Brinkmann, Stefan H. E. Kaufmann
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
Lactate dehydrogenase A (LDHA) mediates interconversion of pyruvate and lactate, and increased lactate turnover is exhibited by malignant and infected immune cells. Hypoxic lung granuloma in Mycobacterium tuberculosis-infected animals present elevate
Externí odkaz:
https://doaj.org/article/1d4e6545a6c14d64b47bf69114bc310d
Autor:
Sandra-Maria Wienhold, Markus C. Brack, Geraldine Nouailles, Gopinath Krishnamoorthy, Imke H. E. Korf, Claudius Seitz, Sarah Wienecke, Kristina Dietert, Corinne Gurtner, Olivia Kershaw, Achim D. Gruber, Anton Ross, Holger Ziehr, Manfred Rohde, Jens Neudecker, Jasmin Lienau, Norbert Suttorp, Stefan Hippenstiel, Andreas C. Hocke, Christine Rohde, Martin Witzenrath
Publikováno v:
Viruses, Vol 14, Iss 1, p 33 (2021)
Respiratory infections caused by multidrug-resistant Acinetobacter baumannii are difficult to treat and associated with high mortality among critically ill hospitalized patients. Bacteriophages (phages) eliminate pathogens with high host specificity
Externí odkaz:
https://doaj.org/article/133b0ff03ec84f789f3f93a9994295ec
Autor:
Gopinath Krishnamoorthy, Peggy Kaiser, Laura Lozza, Karin Hahnke, Hans-Joachim Mollenkopf, Stefan H. E. Kaufmann
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Mycofactocin (MFT) belongs to the class of ribosomally synthesized and posttranslationally modified peptides conserved in many Actinobacteria. Mycobacterium tuberculosis assimilates cholesterol during chronic infection, and its in vitro grow
Externí odkaz:
https://doaj.org/article/d41ea91e2d8345c491431502cbe28df4
Autor:
Frida Arrey, Delia Löwe, Stefanie Kuhlmann, Peggy Kaiser, Pedro Moura-Alves, Gopinath Krishnamoorthy, Laura Lozza, Jeroen Maertzdorf, Tatsiana Skrahina, Alena Skrahina, Martin Gengenbacher, Geraldine Nouailles, Stefan H. E. Kaufmann
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Human immune system mice are highly valuable for in vivo dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB) disease, there is little data on the spatial organization and cellular composition of human imm
Externí odkaz:
https://doaj.org/article/1a112f5d08e5410491e9874807b8f1f8
Autor:
Aliabbas A. Husain, Gopinath Krishnamoorthy, Visai Muruganandah, Socorro Miranda-Hernandez, Harindra D. Sathkumara, Andreas Kupz, Julia Seifert, Rajpal S. Kashyap, Matthew A. Field, Isis Heijmenberg
Publikováno v:
Vaccine. 39:7265-7276
Tuberculosis (TB) is the leading infectious cause of death globally. The only licensed TB vaccine, Bacille Calmette-Guerin (BCG), has low efficacy against TB in adults and is not recommended in people with impaired immunity. The incorporation of the
Autor:
Sandra-Maria Wienhold, Markus C. Brack, Geraldine Nouailles, Gopinath Krishnamoorthy, Imke H. E. Korf, Claudius Seitz, Sarah Wienecke, Kristina Dietert, Corinne Gurtner, Olivia Kershaw, Achim D. Gruber, Anton Ross, Holger Ziehr, Manfred Rohde, Jens Neudecker, Jasmin Lienau, Norbert Suttorp, Stefan Hippenstiel, Andreas C. Hocke, Christine Rohde, Martin Witzenrath
Publikováno v:
Viruses, Vol 14, Iss 33, p 33 (2022)
Viruses; Volume 14; Issue 1; Pages: 33
Viruses; Volume 14; Issue 1; Pages: 33
Respiratory infections caused by multidrug-resistant Acinetobacter baumannii are difficult to treat and associated with high mortality among critically ill hospitalized patients. Bacteriophages (phages) eliminate pathogens with high host specificity