Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gopi Shanker"'
Autor:
Baltazar Gomez‐Mancilla, Jeffrey A. Levy, Subramanian Ganesan, Thomas Faller, Gil Issachar, Ziv Peremen, Offir Laufer, Revital Shani‐Hershkovich, Kostas Biliouris, Ela Walker, Mark P. Healy, Oleksandr Sverdlov, Sachin Desai, S. Nassir Ghaemi, Jang‐Ho Cha, Y. Gopi Shanker
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2236-2252 (2023)
Abstract This single‐center study administered MIJ821 (onfasprodil) as an intravenous infusion to healthy volunteers and included two parts: a single ascending dose study (Part 1) and a repeated intravenous dose study (Part 2). Primary objective wa
Externí odkaz:
https://doaj.org/article/5df246e2bd1843acb8776d80c98f86a6
Autor:
Jingyao Li, Daniel J. Ho, Martin Henault, Chian Yang, Marilisa Neri, Robin Ge, Steffen Renner, Leandra Mansur, Alicia Lindeman, Brian Kelly, Tayfun Tumkaya, Xiaoling Ke, Gilberto Soler-Llavina, Gopi Shanker, Carsten Russ, Marc Hild, Caroline Gubser Keller, Jeremy L. Jenkins, Kathleen A. Worringer, Frederic D. Sigoillot, Robert J. Ihry
Publikováno v:
ACS chemical biology. 17(6)
Unbiased transcriptomic RNA-seq data has provided deep insights into biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84df92c55bb23f5e3de70243ffd28703
https://pubmed.ncbi.nlm.nih.gov/35508359
https://pubmed.ncbi.nlm.nih.gov/35508359
Publikováno v:
MHR: Basic science of reproductive medicine. 6:415-421
Gonadotrophin releasing hormone (GnRH) plays an important role in the reproductive processes of both males and females. It is synthesized by the hypothalamus and binds to a specific receptor on the pituitary to bring about the release of the gonadotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b31c86a0b4eb2350ee3ddb88897164
https://doi.org/10.1093/molehr/6.5.415
https://doi.org/10.1093/molehr/6.5.415
Autor:
Y. Gopi Shanker, A. Jagannadha Rao
Publikováno v:
Molecular Human Reproduction. 5:481-486
The presence of progesterone receptors (PR) in the human placenta has been demonstrated using the reverse transcriptase-polymerase chain reaction technique. It was observed that the amount of PR in the human placenta is less during late gestation. El
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1c0dac2d8c64c882af90f9a6f91b49
https://doi.org/10.1093/molehr/5.5.481
https://doi.org/10.1093/molehr/5.5.481
Publikováno v:
Molecular and Cellular Biochemistry. 187:133-139
Inhibition of synthesis of estradiol 17 beta by the addition of inhibitors of aromatase, a key enzyme in the biosynthesis of estradiol 17 beta, or addition of tamoxifen - an estrogen receptor antagonist, to human placental minces resulted in an incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d3e62f092db20d64fcdf3437e62d23a
https://doi.org/10.1023/a:1006843812495
https://doi.org/10.1023/a:1006843812495
Autor:
Liquan Huang, Y. Gopi Shanker, Fabien Campagne, Zhan Liu, Harel Weinstein, Sami Damak, Minqing Rong, Marianna Max, Robert F. Margolskee
Publikováno v:
Nature genetics. 28(1)
The ability to taste the sweetness of carbohydrate-rich foodstuffs has a critical role in the nutritional status of humans. Although several components of bitter transduction pathways have been identified, the receptors and other sweet transduction e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f37aad8e1a41af579483fe467cfc87
https://pubmed.ncbi.nlm.nih.gov/11326277
https://pubmed.ncbi.nlm.nih.gov/11326277
Publikováno v:
Reproductive Immunology ISBN: 9789401058254
Human placenta by virtue of its ability to produce, protein-peptide and steroid hormones, functions as a transient hypothalamo-pituitary-gonadal axis during pregnancy. In the present study, we have examined some aspects of regulation of GnRH, chorion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f10b7ee336fbc93ef3e9209b6b4882
https://doi.org/10.1007/978-94-011-4197-0_18
https://doi.org/10.1007/978-94-011-4197-0_18
Autor:
A. Jagannadha Rao, Y. Gopi Shanker
Publikováno v:
Biochemistry and molecular biology international. 43(3)
Ex vivo addition of estradiol 17 beta to first trimester or term human placental minces caused a significant increase in the quantity of progesterone produced. Addition of an aromatase inhibitor, CGS 16949 A, or the estrogen receptor antagonist, ICI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c26a66b09f3dc48d96cdd5a9ad81376
https://pubmed.ncbi.nlm.nih.gov/9352078
https://pubmed.ncbi.nlm.nih.gov/9352078
Publikováno v:
Biochemistry and molecular biology international. 42(6)
The human placenta produces large quantities of progesterone, the function and target tissues of action of which during pregnancy are not completely understood. Although it has been suggested that placenta itself could be a potential target tissue fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b544e2db441aa504e586117a7d22a752
https://pubmed.ncbi.nlm.nih.gov/9305541
https://pubmed.ncbi.nlm.nih.gov/9305541