Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gopi S. Gadupudi"'
Autor:
Gopi S. Gadupudi, James Watt, Casey F. Pulliam, Martin J. J. Ronis, Ashlee E Williams, Alexander W. Alund, Larry W. Robertson, Ezazul Haque
Publikováno v:
Arch Toxicol
Skeletal toxicity has been reported following exposure to polychlorinated biphenyl (PCB) mixtures. However, molecular mechanisms remain poorly understood. We exposed groups of male 4–5-week-old Sprague–Dawley rats to 3,3′, 4, 4′, 5-pentachlor
Autor:
Brianna J. Stubbs, Gopi S. Gadupudi, Donald G. Stump, Andrey I. Nikiforov, John C. Newman, Nancy Higley, Sari L. Weston, Marisa O. Rihner, Gregory A. Krane, Eric Verdin
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 150
Bis-hexanoyl (R)-1,3-butanediol (BH-BD) is novel ketone ester undergoing development as a food ingredient to achieve nutritional ketosis in humans. Male and female Crl:CD(SD) rats were administered BH-BD twice daily at 9000, 12,000 or 15,000 mg/kg/da
Autor:
Gopi S. Gadupudi, Nazmin Eti, Michele L Osborn, Shana Littleton, Martin J. J. Ronis, Khursheed Iqbal, Ashlee E Williams, Larry J. Suva, James Watt, Kartik Shankar, Larry W. Robertson, Cole Maimone, Michael J. Soares, Kim Brint Pedersen
Publikováno v:
Toxicol Sci
Epidemiological evidence links polychlorinated biphenyls (PCBs) to skeletal toxicity, however mechanisms whereby PCBs affect bone are poorly studied. In this study, coplanar PCB 126 (5 μmol/kg) or corn oil vehicle was administered to N = 5 and 6 mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a99a8945492c5b5e0ba565fdf49a24
https://europepmc.org/articles/PMC7197949/
https://europepmc.org/articles/PMC7197949/
PCB126 Inhibits the Activation of AMPK-CREB Signal Transduction Required for Energy Sensing in Liver
Autor:
Fabian A Sandgruber, Benjamin A Elser, Katherine N. Gibson-Corley, Xueshu Li, Larry W. Robertson, Gopi S. Gadupudi
Publikováno v:
Toxicological Sciences. 163:440-453
3,3′,4,4′,5-pentachlorobiphenyl (PCB126), a dioxin-like PCB, elicits toxicity through a wide array of noncarcinogenic effects, including metabolic syndrome, wasting, and nonalcoholic fatty-liver disease. Previously, we reported decreases in the t
Autor:
Aloysius J. Klingelhutz, Gabriele Ludewig, Gopi S. Gadupudi, Francoise A. Gourronc, Larry W. Robertson
Publikováno v:
Toxicology in Vitro. 29:132-141
Emerging evidence indicates that persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs), are involved in the development of diabetes. Dysfunctional adipocytes play a significant role in initiating insulin resistance. Preadip
Autor:
Gabriele Ludewig, Larry W. Robertson, Gopi S. Gadupudi, Kiran Dhakal, Michael W. Duffel, Hans-Joachim Lehmler
Polychlorinated biphenyls (PCBs), a group of 209 congeners that differ in the number and position of chlorines on the biphenyl ring, are anthropogenic chemicals that belong to the persistent organic pollutants (POPs). For many years, PCBs have been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d21958551537119fb5b5fddf245c61a
https://europepmc.org/articles/PMC5785587/
https://europepmc.org/articles/PMC5785587/
Publikováno v:
Chemical research in toxicology. 29(9)
The dioxin-like PCB126 elicits toxicity in various target organs. In rat liver, an alteration in the transcript levels of several genes involved in glucose and fatty acid metabolism provides insights into the origin of its hepatotoxicity. To explore
Autor:
King-Thom Chung, Gopi S. Gadupudi
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 726:200-208
Several clinical studies have reported that an increase in excretion of tryptophan metabolites 3-hydroxyanthranilic acid (3-OHAA), anthranilic acid (AA) and other metabolites in the urine of bladder cancer patients are implicated to play a role in th
Autor:
Aloysius J. Klingelhutz, Alicia K. Olivier, William D. Klaren, Larry W. Robertson, Gopi S. Gadupudi
3,3',4,4',5-Pentachlorobiphenyl (PCB126), a dioxin-like polychlorinated biphenyl (PCB) and a potent aryl hydrocarbon receptor (AhR) agonist, is implicated in the disruption of both carbohydrate and lipid metabolism which ultimately leads to wasting d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43743757ae0aba179bc1bd79ef3094e
https://europepmc.org/articles/PMC4731404/
https://europepmc.org/articles/PMC4731404/