Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Gopalasingam P"'
Autor:
Christoph Gerle, Chimari Jiko, Atsuki Nakano, Ken Yokoyama, Chai C. Gopalasingam, Hideki Shigematsu, Kazuhiro Abe
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107423- (2024)
Practical and conceptual barriers have kept human F-ATP synthase out of reach as a target for the treatment of human diseases. Although this situation has persisted for decades, it may change in the near future. In this review the principal functiona
Externí odkaz:
https://doaj.org/article/e62c9702b05742ac8c89d6f155c997bb
Autor:
Rebeca Campos-Sánchez, Ian Willis, Piraveen Gopalasingam, Daniel López-Juárez, Marco Cristancho, Cath Brooksbank, on behalf of The CABANA Consortium
Publikováno v:
Frontiers in Education, Vol 9 (2024)
The CABANA project (Capacity Building for Bioinformatics in Latin America) was funded by the UK’s Global Challenges Research Fund in 2017 with the aim to strengthen the bioinformatics capacity and extend its applications in Latin America focused on
Externí odkaz:
https://doaj.org/article/b91bee586d904958ad7a98f9085bddbc
Autor:
Oskar Kjærgaard Hørsdal, Niels Moeslund, Kristoffer Berg-Hansen, Roni Nielsen, Niels Møller, Hans Eiskjær, Henrik Wiggers, Nigopan Gopalasingam
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Lactate is traditionally recognized as a by-product of anaerobic metabolism. However, lactate is a preferred oxidative substrate for stressed myocardium. Exogenous lactate infusion increases cardiac output (CO). The exact mechanis
Externí odkaz:
https://doaj.org/article/65a963583d804b29bade278454b76dc0
Autor:
Nigopan Gopalasingam, Niels Moeslund, Kristian Hylleberg Christensen, Kristoffer Berg‐Hansen, Jacob Seefeldt, Casper Homilius, Erik Nguyen Nielsen, Mie Ringgaard Dollerup, Aage K. Alstrup Olsen, Mogens Johannsen, Ebbe Boedtkjer, Niels Møller, Hans Eiskjær, Lars Christian Gormsen, Roni Nielsen, Henrik Wiggers
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 8 (2024)
Background The ketone body 3‐hydroxybutyrate (3‐OHB) increases cardiac output (CO) by 35% to 40% in healthy people and people with heart failure. The mechanisms underlying the effects of 3‐OHB on myocardial contractility and loading conditions
Externí odkaz:
https://doaj.org/article/5b06f1a0c49843c0ad0ad5a5885374ac
Autor:
Kazuhiro Abe, Mami Ozako, Miki Inukai, Yoe Matsuyuki, Shinnosuke Kitayama, Chisato Kanai, Chiaki Nagai, Chai C. Gopalasingam, Christoph Gerle, Hideki Shigematsu, Nariyoshi Umekubo, Satoshi Yokoshima, Atsushi Yoshimori
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Existing drugs often suffer in their effectiveness due to detrimental side effects, low binding affinity or pharmacokinetic problems. This may be overcome by the development of distinct compounds. Here, we exploit the rich structural basis o
Externí odkaz:
https://doaj.org/article/cece4c3a0c2549c0b39e71717c9e426c
Autor:
Mads Svart, Nikolaj Rittig, Thien Vinh Luong, Nigopan Gopalasingam, Esben Thyssen Vestergaard, Lars Gormsen, Esben Søndergaard, Henrik Holm Thomsen, Claus H. Gravholt
Publikováno v:
Journal of Nutrition and Metabolism, Vol 2024 (2024)
Background. Beta-hydroxybuturate (β-OHB) supplements are commonly utilized in sports by both recreational and professional athletes. In a recent study, we observed a drop in testosterone levels following the oral ingestion of racemic sodium-β-OHB.
Externí odkaz:
https://doaj.org/article/128265b9086543378da4d283e1dd6d31
Akademický článek
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Akademický článek
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Autor:
Yuya Nishida, Sachiko Yanagisawa, Rikuri Morita, Hideki Shigematsu, Kyoko Shinzawa-Itoh, Hitomi Yuki, Satoshi Ogasawara, Ken Shimuta, Takashi Iwamoto, Chisa Nakabayashi, Waka Matsumura, Hisakazu Kato, Chai Gopalasingam, Takemasa Nagao, Tasneem Qaqorh, Yusuke Takahashi, Satoru Yamazaki, Katsumasa Kamiya, Ryuhei Harada, Nobuhiro Mizuno, Hideyuki Takahashi, Yukihiro Akeda, Makoto Ohnishi, Yoshikazu Ishii, Takashi Kumasaka, Takeshi Murata, Kazumasa Muramoto, Takehiko Tosha, Yoshitsugu Shiro, Teruki Honma, Yasuteru Shigeta, Minoru Kubo, Seiji Takashima, Yasunori Shintani
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Antimicrobial resistance to currently available antibiotics requires innovation of antibiotics. Here, the authors identify a critical inhibitory site in an energy-producing enzyme, which can lead to rational design of antibiotics.
Externí odkaz:
https://doaj.org/article/4c52d610a36f4a98ac427d2ed62acfe7