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Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Solveig K. Sieberts, Fan Zhu, Javier García-García, Eli Stahl, Abhishek Pratap, Gaurav Pandey, Dimitrios Pappas, Daniel Aguilar, Bernat Anton, Jaume Bonet, Ridvan Eksi, Oriol Fornés, Emre Guney, Hongdong Li, Manuel Alejandro Marín, Bharat Panwar, Joan Planas-Iglesias, Daniel Poglayen, Jing Cui, Andre O. Falcao, Christine Suver, Bruce Hoff, Venkat S. K. Balagurusamy, Donna Dillenberger, Elias Chaibub Neto, Thea Norman, Tero Aittokallio, Muhammad Ammad-ud-din, Chloe-Agathe Azencott, Víctor Bellón, Valentina Boeva, Kerstin Bunte, Himanshu Chheda, Lu Cheng, Jukka Corander, Michel Dumontier, Anna Goldenberg, Peddinti Gopalacharyulu, Mohsen Hajiloo, Daniel Hidru, Alok Jaiswal, Samuel Kaski, Beyrem Khalfaoui, Suleiman Ali Khan, Eric R. Kramer, Pekka Marttinen, Aziz M. Mezlini, Bhuvan Molparia, Matti Pirinen, Janna Saarela, Matthias Samwald, Véronique Stoven, Hao Tang, Jing Tang, Ali Torkamani, Jean-Phillipe Vert, Bo Wang, Tao Wang, Krister Wennerberg, Nathan E. Wineinger, Guanghua Xiao, Yang Xie, Rae Yeung, Xiaowei Zhan, Cheng Zhao, Members of the Rheumatoid Arthritis Challenge Consortium, Jeff Greenberg, Joel Kremer, Kaleb Michaud, Anne Barton, Marieke Coenen, Xavier Mariette, Corinne Miceli, Nancy Shadick, Michael Weinblatt, Niek de Vries, Paul P. Tak, Danielle Gerlag, Tom W. J. Huizinga, Fina Kurreeman, Cornelia F. Allaart, S. Louis Bridges Jr., Lindsey Criswell, Larry Moreland, Lars Klareskog, Saedis Saevarsdottir, Leonid Padyukov, Peter K. Gregersen, Stephen Friend, Robert Plenge, Gustavo Stolovitzky, Baldo Oliva, Yuanfang Guan, Lara M. Mangravite
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Rheumatoid arthritis patients respond differently to anti-TNF treatment. Using community-based challenge, the authors show that currently available data does not reveal meaningful genetic predictors of response to anti-TNF therapy, thus confirming cl
Externí odkaz:
https://doaj.org/article/75f77ca55d0d4c649c320c5fdaffe293
Autor:
Bhagwan Yadav, Peddinti Gopalacharyulu, Tea Pemovska, Suleiman A. Khan, Agnieszka Szwajda, Jing Tang, Krister Wennerberg, Tero Aittokallio
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 10, Pp 1255-1264 (2015)
Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addicti
Externí odkaz:
https://doaj.org/article/26d5126068be4c76814df74a456af733
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171078 (2017)
Sarraceniaceae is a New World carnivorous plant family comprising three genera: Darlingtonia, Heliamphora, and Sarracenia. The plants occur in nutrient-poor environments and have developed insectivorous capability in order to supplement their nutrien
Externí odkaz:
https://doaj.org/article/0c10f34b72074b21a81f47973458909d
Autor:
Vidya R. Velagapudi, Rahil Hezaveh, Christopher S. Reigstad, Peddinti Gopalacharyulu, Laxman Yetukuri, Sama Islam, Jenny Felin, Rosie Perkins, Jan Borén, Matej Orešič, Fredrik Bäckhed
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 1101-1112 (2010)
The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and the lipidomes of ser
Externí odkaz:
https://doaj.org/article/f9a2e7b724a545cc9ea85327e0368bb7
Autor:
Solveig K. Sieberts, Fan Zhu, Javier García-García, Eli Stahl, Abhishek Pratap, Gaurav Pandey, Dimitrios Pappas, Daniel Aguilar, Bernat Anton, Jaume Bonet, Ridvan Eksi, Oriol Fornés, Emre Guney, Hongdong Li, Manuel Alejandro Marín, Bharat Panwar, Joan Planas-Iglesias, Daniel Poglayen, Jing Cui, Andre O. Falcao, Christine Suver, Bruce Hoff, Venkat S. K. Balagurusamy, Donna Dillenberger, Elias Chaibub Neto, Thea Norman, Tero Aittokallio, Muhammad Ammad-ud-din, Chloe-Agathe Azencott, Víctor Bellón, Valentina Boeva, Kerstin Bunte, Himanshu Chheda, Lu Cheng, Jukka Corander, Michel Dumontier, Anna Goldenberg, Peddinti Gopalacharyulu, Mohsen Hajiloo, Daniel Hidru, Alok Jaiswal, Samuel Kaski, Beyrem Khalfaoui, Suleiman Ali Khan, Eric R. Kramer, Pekka Marttinen, Aziz M. Mezlini, Bhuvan Molparia, Matti Pirinen, Janna Saarela, Matthias Samwald, Véronique Stoven, Hao Tang, Jing Tang, Ali Torkamani, Jean-Phillipe Vert, Bo Wang, Tao Wang, Krister Wennerberg, Nathan E. Wineinger, Guanghua Xiao, Yang Xie, Rae Yeung, Xiaowei Zhan, Cheng Zhao, Members of the Rheumatoid Arthritis Challenge Consortium, Jeff Greenberg, Joel Kremer, Kaleb Michaud, Anne Barton, Marieke Coenen, Xavier Mariette, Corinne Miceli, Nancy Shadick, Michael Weinblatt, Niek de Vries, Paul P. Tak, Danielle Gerlag, Tom W. J. Huizinga, Fina Kurreeman, Cornelia F. Allaart, S. Louis Bridges Jr., Lindsey Criswell, Larry Moreland, Lars Klareskog, Saedis Saevarsdottir, Leonid Padyukov, Peter K. Gregersen, Stephen Friend, Robert Plenge, Gustavo Stolovitzky, Baldo Oliva, Yuanfang Guan, Lara M. Mangravite
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 7: Article number: 12460 (2016); Published: 23 August 2016; Updated: 10 October 2016. The HTML version of this Article incorrectly duplicated the authors S. Louis Bridges, Lindsey Criswell, Larry Moreland, Lars Klareskog, Saedis
Externí odkaz:
https://doaj.org/article/8cf02848677143269013f79182f99711
Autor:
Xiaojun Xu, Peddinti Gopalacharyulu, Tuulikki Seppänen-Laakso, Anna-Liisa Ruskeepää, Cho Cho Aye, Brian P Carson, Silvia Mora, Matej Orešič, Aurelio A Teleman
Publikováno v:
PLoS Genetics, Vol 8, Iss 1, p e1002478 (2012)
The insulin/IGF signaling pathway is a highly conserved regulator of metabolism in flies and mammals, regulating multiple physiological functions including lipid metabolism. Although insulin signaling is known to regulate the activity of a number of
Externí odkaz:
https://doaj.org/article/6eae0debc1224f6d887dd722cd41f8a3
Autor:
Marko Sysi-Aho, Andrey Ermolov, Peddinti V Gopalacharyulu, Abhishek Tripathi, Tuulikki Seppänen-Laakso, Johanna Maukonen, Ismo Mattila, Suvi T Ruohonen, Laura Vähätalo, Laxman Yetukuri, Taina Härkönen, Erno Lindfors, Janne Nikkilä, Jorma Ilonen, Olli Simell, Maria Saarela, Mikael Knip, Samuel Kaski, Eriika Savontaus, Matej Orešič
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002257 (2011)
Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturb
Externí odkaz:
https://doaj.org/article/efa2394923bf45da8529c7eec04cc069
Autor:
Kirsi H Pietiläinen, Tomasz Róg, Tuulikki Seppänen-Laakso, Sam Virtue, Peddinti Gopalacharyulu, Jing Tang, Sergio Rodriguez-Cuenca, Arkadiusz Maciejewski, Jussi Naukkarinen, Anna-Liisa Ruskeepää, Perttu S Niemelä, Laxman Yetukuri, Chong Yew Tan, Vidya Velagapudi, Sandra Castillo, Heli Nygren, Tuulia Hyötyläinen, Aila Rissanen, Jaakko Kaprio, Hannele Yki-Järvinen, Ilpo Vattulainen, Antonio Vidal-Puig, Matej Orešič
Publikováno v:
PLoS Biology, Vol 9, Iss 6, p e1000623 (2011)
Identification of early mechanisms that may lead from obesity towards complications such as metabolic syndrome is of great interest. Here we performed lipidomic analyses of adipose tissue in twin pairs discordant for obesity but still metabolically c
Externí odkaz:
https://doaj.org/article/fcf716f0b0514305ae1327d2d91cb67b