Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gopal Karemore"'
Autor:
Indranil Paul, Dante Bolzan, Ahmed Youssef, Keith A. Gagnon, Heather Hook, Gopal Karemore, Michael U. J. Oliphant, Weiwei Lin, Qian Liu, Sadhna Phanse, Carl White, Dzmitry Padhorny, Sergei Kotelnikov, Christopher S. Chen, Pingzhao Hu, Gerald V. Denis, Dima Kozakov, Brian Raught, Trevor Siggers, Stefan Wuchty, Senthil K. Muthuswamy, Andrew Emili
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Epithelial-to-mesenchymal transition (EMT) is a complex process regulated at multiple molecular levels. Here, the authors implement an analytic framework - PAMAF - to integrate data from twelve distinct omics modalities, which they use to understand
Externí odkaz:
https://doaj.org/article/f07b77169d2c404490c225320410df32
Autor:
Anna-Kathrine Pedersen, Anamarija Pfeiffer, Gopal Karemore, Vyacheslav Akimov, Dorte B. Bekker-Jensen, Blagoy Blagoev, Chiara Francavilla, Jesper V. Olsen
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102321- (2021)
Summary: Neuroblastoma is a highly heterogeneous embryonal solid tumor of the sympathetic nervous system. As some tumors can be treated to undergo differentiation, investigating this process can guide differentiation-based therapies of neuroblastoma.
Externí odkaz:
https://doaj.org/article/5501645317bc4f13a024b87b28776561
Autor:
Ronni S. Pedersen, Gopal Karemore, Thorkell Gudjonsson, Maj-Britt Rask, Beate Neumann, Jean-Karim Hériché, Rainer Pepperkok, Jan Ellenberg, Daniel W. Gerlich, Jiri Lukas, Claudia Lukas
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
DNA damage arising from replication stress is well studied, but the effect of mitotic errors on genome integrity is less understood. Here the authors knock down 47 mitotic regulators and record how they impact on DNA breakage events, providing a reso
Externí odkaz:
https://doaj.org/article/44999825db4e41e7abeaf600944f0a5b
Autor:
Indranil Paul, Dante Bolzan, Ahmed Youssef, Keith A. Gagnon, Heather Hook, Gopal Karemore, Michael UJ Oliphant, Weiwei Lin, Qian Liu, Sadhna Phanse, Carl White, Dzmitry Padhorny, Sergei Kotelnikov, Guillaume P. Andrieu, Christopher S. Chen, Pingzhao Hu, Gerald V. Denis, Dima Kozakov, Brian Raught, Trevor Siggers, Stefan Wuchty, Senthil K. Muthuswamy, Andrew Emili
SummaryEpithelial to mesenchymal transition (EMT) is a complex cellular program proceeding through a hybrid E/M state linked to cancer-associated stemness, migration and chemoresistance. Deeper molecular understanding of this dynamic physiological la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac22c5432f1ed48ff2dce3a928e6cd1f
https://doi.org/10.1101/2021.06.01.446492
https://doi.org/10.1101/2021.06.01.446492
Autor:
Akiko Harauma, Kathrin Landgraf, Jeffrey B. Travers, Edwards A. Park, Yukino Hoshi, Haidong Yu, Christina Lucas, Lajos Balogh, Jonas Coßmann, Michael Scott Kuefner, Tamás Röszer, Julianna Thuróczy, Sedat Dilbaz, Toru Moriguchi, Antje Körner, Susanne Brodesser, Annika Herwig, Christine M. Rapp, Victoria Diedrich, Gopal Karemore, Anh Cuong Hoang
Publikováno v:
J Clin Invest
Yu, H, Dilbaz, S, Coßmann, J, Hoang, A C, Diedrich, V, Herwig, A, Harauma, A, Hoshi, Y, Moriguchi, T, Landgraf, K, Körner, A, Lucas, C, Brodesser, S, Balogh, L, Thuróczy, J, Karemore, G, Kuefner, M S, Park, E A, Rapp, C, Travers, J B & Röszer, T 2019, ' Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages ', The Journal of Clinical Investigation, vol. 129, no. 6, pp. 2485-2499 . https://doi.org/10.1172/JCI125646
Yu, H, Dilbaz, S, Coßmann, J, Hoang, A C, Diedrich, V, Herwig, A, Harauma, A, Hoshi, Y, Moriguchi, T, Landgraf, K, Körner, A, Lucas, C, Brodesser, S, Balogh, L, Thuróczy, J, Karemore, G, Kuefner, M S, Park, E A, Rapp, C, Travers, J B & Röszer, T 2019, ' Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages ', The Journal of Clinical Investigation, vol. 129, no. 6, pp. 2485-2499 . https://doi.org/10.1172/JCI125646
Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious publ
Autor:
Josefin S Bartholdson, Sara Caviglia, Elke A. Ober, Aliaksandr Dzementsei, Jordi Cayuso, Gopal Karemore, Gavin J. Wright, Johanna C. Fischer
Publikováno v:
Developmental Cell
Summary Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b
Autor:
Fena Ochs, Maj-Britt Rask, Ezequiel Miron, Veronica J. Buckle, Lothar Schermelleh, Jill M. Brown, Jiri Lukas, Gopal Karemore, Hana Sedlackova, Marko Lampe, Claudia Lukas
Publikováno v:
Ochs, F, Karemore, G, Miron, E, Brown, J, Sedlackova, H, Rask, M-B, Lampe, M, Buckle, V, Schermelleh, L, Lukas, J & Lukas, C 2019, ' Stabilization of chromatin topology safeguards genome integrity ', Nature, vol. 574, no. 7779, pp. 571-574 . https://doi.org/10.1038/s41586-019-1659-4
To safeguard genome integrity in response to DNA double-strand breaks (DSBs), mammalian cells mobilize the neighbouring chromatin to shield DNA ends against excessive resection that could undermine repair fidelity and cause damage to healthy chromoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc78dd728e51219c615230411c69e824
https://ora.ox.ac.uk/objects/uuid:8f763984-002c-444d-a44c-d8f1d99d36e7
https://ora.ox.ac.uk/objects/uuid:8f763984-002c-444d-a44c-d8f1d99d36e7
Autor:
Fena, Ochs, Gopal, Karemore, Ezequiel, Miron, Jill, Brown, Hana, Sedlackova, Maj-Britt, Rask, Marko, Lampe, Veronica, Buckle, Lothar, Schermelleh, Jiri, Lukas, Claudia, Lukas
Publikováno v:
Nature. 574(7779)
To safeguard genome integrity in response to DNA double-strand breaks (DSBs), mammalian cells mobilize the neighbouring chromatin to shield DNA ends against excessive resection that could undermine repair fidelity and cause damage to healthy chromoso
Autor:
Thomas Wild, Marin Barisic, Chunaram Choudhary, Gopal Karemore, Susanne Hellmuth, Olaf Stemmann, Magda Budzowska, Susana Eibes
Publikováno v:
Cell Reports
Wild, T, Budzowska, M, Hellmuth, S, Eibes, S, Karemore, G, Barisic, M, Stemmann, O & Choudhary, C 2018, ' Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint ', Cell Reports, vol. 25, no. 9, 2317-2328.e5 . https://doi.org/10.1016/j.celrep.2018.10.104
Wild, T, Budzowska, M, Hellmuth, S, Eibes, S, Karemore, G, Barisic, M, Stemmann, O & Choudhary, C 2018, ' Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint ', Cell Reports, vol. 25, no. 9, 2317-2328.e5 . https://doi.org/10.1016/j.celrep.2018.10.104
Summary The multisubunit ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) is essential for mitosis by promoting timely degradation of cyclin B1. APC/C is tightly regulated by the spindle assembly checkpoint (SAC), which involves MPS1 and
The multisubunit ubiquitin ligase APC/C (anaphase promoting complex/cyclosome) is essential for mitosis by promoting timely degradation of cyclin B1. Proper timing of APC/C activation is regulated by the spindle assembly checkpoint (SAC), which is in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad1fa89912f1cc6db32bb2c4abb4b7e