Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gopal K. Soppa"'
Publikováno v:
Cryobiology. 71:161-163
Early diagnosis of lung cancer still poses a major issue, with a large proportion of patients diagnosed at late stages. Therapeutic options and treatment remain limited in these patients. In most cases only palliative therapies are available to allev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7a054513bbbef2e49a4bf04baad840
https://doi.org/10.1016/j.cryobiol.2015.06.001
https://doi.org/10.1016/j.cryobiol.2015.06.001
Autor:
Gopal K. Soppa, Magdi H. Yacoub, Alexey Moshkov, Cesare M. Terracciano, Julia Gorelik, Sara Abou Al-Saud, Manoraj Navaratnarajah, Abeer A. Al Masri, Urszula Siedlecka, Michael Ibrahim
Publikováno v:
The FASEB Journal
Prolonged mechanical unloading (UN) of the heart is associated with detrimental changes to the structure and function of cardiomyocytes. The mechanisms underlying these changes are unknown. In this study, we report the influence of UN on excitation-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6f99a60877fd065675aed228a9e8ed
https://doi.org/10.1096/fj.10-156638
https://doi.org/10.1096/fj.10-156638
Autor:
Ken Suzuki, Satsuki Fukushima, Mark A. Stagg, Samuel Youssef, Cesare M. Terracciano, Urszula Siedlecka, Magdi H. Yacoub, Joon Ha Lee, Gopal K. Soppa
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 296:H927-H936
Adult progenitor cell transplantation has been proposed for the treatment of heart failure, but the mechanisms effecting functional improvements remain unknown. The aim of this study was to test the hypothesis that, in failing hearts treated with cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f513c97fd777163f1a5aedbb951cce
https://doi.org/10.1152/ajpheart.00931.2008
https://doi.org/10.1152/ajpheart.00931.2008
Autor:
Mark A. Stagg, Joon Ha Lee, Gopal K. Soppa, M. Arora, Sian E. Harding, Urszula Siedlecka, Cesare M. Terracciano, Magdi H. Yacoub, Theofilos M. Kolettis
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 295:H1917-H1926
Clenbuterol, a compound classified as a β2-adrenoceptor (AR) agonist, has been employed in combination with left ventricular assist devices (LVADs) to treat patients with severe heart failure. Previous studies have shown that chronic administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a185e3c128ba32bf240f3fa282b5c4
https://doi.org/10.1152/ajpheart.00258.2008
https://doi.org/10.1152/ajpheart.00258.2008
Autor:
Fiona Mead, Urszula Siedlecka, Narla Mohandas, Jennifer C. Pinder, Pauline M. Bennett, Edward A. Carter, Mark A. Stagg, Anthony J. Baines, Nadia Sohrabi, Gopal K. Soppa, Pamela M. Taylor-Harris, Cesare M. Terracciano, Magdi H. Yacoub
Publikováno v:
Circulation Research. 103:855-863
The 4.1 proteins are a family of multifunctional adaptor proteins. They promote the mechanical stability of plasma membranes by interaction with the cytoskeletal proteins spectrin and actin and are required for the cell surface expression of a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a80f5119872e19ccd00fe74c659ccd0a
https://doi.org/10.1161/circresaha.108.176461
https://doi.org/10.1161/circresaha.108.176461
Publikováno v:
Current Opinion in Cardiology. 23:206-218
Purpose of review There is considerable increase in the use of left ventricular assist devices for the treatment of severe heart failure. Traditionally viewed as a bridge to transplantation and more recently as a destination therapy, left ventricular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb9ea4941a1f4ed2124e41c0f802202
https://doi.org/10.1097/hco.0b013e3282fc7010
https://doi.org/10.1097/hco.0b013e3282fc7010
Autor:
Leanne E. Felkin, Cesare M. Terracciano, Magdi H. Yacoub, Joon Ha Lee, Samuel Youssef, Gopal K. Soppa, Urszula Siedlecka, Paul J.R. Barton, Mark A. Stagg
Publikováno v:
Cardiovascular Research
Aims Combined left ventricular assist device (LVAD) and pharmacological therapy has been proposed to favour myocardial recovery in patients with end-stage heart failure (HF). Clenbuterol (Clen), a β2-adrenoceptor (β2-AR) agonist, has been used as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ee2b89ac39617334045794b9a44aa3
http://europepmc.org/articles/PMC5436743
http://europepmc.org/articles/PMC5436743
Autor:
Klára Farkasfalvi, István Szokodi, Gopal K. Soppa, Mark A. Stagg, Magdi H. Yacoub, Nandor Marczin, Cesare M. Terracciano, Steven R. Coppen, Urszula Siedlecka, Joon Ha Lee
Publikováno v:
Biochemical and Biophysical Research Communications. 357:889-895
Apelin, the ligand for the angiotensin receptor like-1, has been implicated in the pathogenesis of atrial fibrillation and heart failure. However, it is unknown if apelin has direct effects on cardiomyocyte contractility and electrophysiology. APJ-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0095cd8f4b4d61c58afe7cad28f052
https://doi.org/10.1016/j.bbrc.2007.04.017
https://doi.org/10.1016/j.bbrc.2007.04.017
Autor:
Mark A. Stagg, Maren U Koban, Cesare M. Terracciano, Gopal K. Soppa, Magdi H. Yacoub, Urszula Siedlecka, Joon Ha Lee
Publikováno v:
Annals of the New York Academy of Sciences. 1099:349-360
Different strategies can, at least in certain conditions, prevent or reverse myocardial remodeling due to heart failure and induce myocardial functional improvement. Na+/Ca2+ exchanger (NCX) is considered a major player in the pathophysiology of hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338834e26f133a00106580ce2705a5c9
https://doi.org/10.1196/annals.1387.061
https://doi.org/10.1196/annals.1387.061
Autor:
Cesare M. Terracciano, Aalya Malik, Ryszard T. Smolenski, Najma Latif, Ada H.Y. Yuen, Magdi H. Yacoub, Joanna Karbowska, Zdzislaw Kochan, Gopal K. Soppa
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 288:H1468-H1476
Clenbuterol (Clen), a β2-agonist, is known to produce skeletal and myocardial hypertrophy. This compound has recently been used in combination with left ventricular assist devices for the treatment of end-stage heart failure to reverse or prevent th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f52f4fcbf0fb497cf02850d3b1630cb
https://doi.org/10.1152/ajpheart.00624.2004
https://doi.org/10.1152/ajpheart.00624.2004