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Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates.

Autor: Slingsby MHL; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. martina.slingsby@childrens.harvard.edu., Vijey P; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Tsai IT; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Roweth H; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Couldwell G; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Wilkie AR; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Gaus H; Nonclinical Development, Ionis Pharmaceuticals Inc., Carlsbad, CA., Goolsby JM; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Okazaki R; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Terkovich BE; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Semple JW; Departments of Pharmacology and Medicine, University of Toronto, Toronto, Canada; Division of Hematology and Transfusion Medicine, Lund University, Lund., Thon JN; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Henry SP; Nonclinical Development, Ionis Pharmaceuticals Inc., Carlsbad, CA., Narayanan P; Nonclinical Development, Ionis Pharmaceuticals Inc., Carlsbad, CA., Italiano JE Jr; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Publikováno v: Haematologica [Haematologica] 2022 Feb 01; Vol. 107 (2), pp. 519-531. Date of Electronic Publication: 2022 Feb 01.