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Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically.
Autor: Riches LC; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Trinidad AG; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Hughes G; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Jones GN; Translational Medicine, Oncology R&D, Oncology, AstraZeneca, Cambridge, United Kingdom., Hughes AM; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Thomason AG; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Gavine P; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Cui A; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Ling S; Quantitative Biology, Discovery Science, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Stott J; Quantitative Biology, Discovery Science, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Clark R; Quantitative Biology, Discovery Science, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Peel S; Quantitative Biology, Discovery Science, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Gill P; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Goodwin LM; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Smith A; DMPK, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Pike KG; Chemistry, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Barlaam B; Chemistry, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Pass M; Oncology R&D, AstraZeneca, Cambridge, United Kingdom., O'Connor MJ; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Smith G; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Cadogan EB; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom. elaine.cadogan@astrazeneca.com.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2020 Jan; Vol. 19 (1), pp. 13-25. Date of Electronic Publication: 2019 Sep 18.
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Akademický článek
Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.
Autor: Ashford AL; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. anne.ashford@babraham.ac.uk., Dunkley TP; AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.; Roche Innovation Center Basel, Basel, Switzerland., Cockerill M; AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.; Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK., Rowlinson RA; AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK., Baak LM; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Gallo R; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Balmanno K; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Goodwin LM; AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK., Ward RA; AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK., Lochhead PA; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Guichard S; AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.; AstraZeneca, Waltham, MA, 02451, USA., Hudson K; AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK., Cook SJ; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. simon.cook@babraham.ac.uk.
Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2016 Feb; Vol. 73 (4), pp. 883-900. Date of Electronic Publication: 2015 Sep 07.
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Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.
Autor: Schug ZT; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Peck B; Cancer Research UK, London Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Jones DT; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Zhang Q; Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Grosskurth S; AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK., Alam IS; Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK., Goodwin LM; AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK., Smethurst E; Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Mason S; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Blyth K; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., McGarry L; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., James D; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Shanks E; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Kalna G; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Saunders RE; Cancer Research UK, London Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Jiang M; Cancer Research UK, London Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Howell M; Cancer Research UK, London Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Lassailly F; Cancer Research UK, London Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Thin MZ; Cancer Research UK, London Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Spencer-Dene B; Cancer Research UK, London Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Stamp G; Cancer Research UK, London Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., van den Broek NJ; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Mackay G; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Bulusu V; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Kamphorst JJ; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Tardito S; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Strachan D; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Harris AL; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Aboagye EO; Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK., Critchlow SE; AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK., Wakelam MJ; Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Schulze A; Cancer Research UK, London Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Gottlieb E; Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address: e.gottlieb@beatson.gla.ac.uk.
Publikováno v: Cancer cell [Cancer Cell] 2015 Jan 12; Vol. 27 (1), pp. 57-71.
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