Preclinical evidence for the effective use of TL-895, a highly selective and potent second-generation BTK inhibitor, for the treatment of B-cell malignancies.

Autor: Goodstal SM; Research Unit Oncology, EMD Serono Research and Development Institute, Inc., 45A Middlesex Turnpike, Billerica, MA, 01821, USA. samantha.goodstal@emdserono.com., Lin J; Research Unit Oncology, EMD Serono Research and Development Institute, Inc., 45A Middlesex Turnpike, Billerica, MA, 01821, USA., Crandall T; Research Unit Oncology, EMD Serono Research and Development Institute, Inc., 45A Middlesex Turnpike, Billerica, MA, 01821, USA., Crowley L; Research Unit Oncology, EMD Serono Research and Development Institute, Inc., 45A Middlesex Turnpike, Billerica, MA, 01821, USA., Bender AT; Research Unit Immunology, EMD Serono Research and Development Institute, Inc., Billerica, MA, 01821, USA., Pereira A; Research Unit Immunology, EMD Serono Research and Development Institute, Inc., Billerica, MA, 01821, USA., Soloviev M; Protein Engineering Antibody Technologies, EMD Serono Research and Development Institute, Inc., Billerica, MA, 01821, USA., Wesolowski JS; Protein Engineering Antibody Technologies, EMD Serono Research and Development Institute, Inc., Billerica, MA, 01821, USA., Iadevaia R; Research Unit Oncology, EMD Serono Research and Development Institute, Inc., 45A Middlesex Turnpike, Billerica, MA, 01821, USA., Schelhorn SE; Oncology Bioinformatics Quantitative Pharmacology and Drug Disposition (QPD) Biopharma, Merck KGaA, 64293, Darmstadt, Germany., Ross E; Oncology Bioinformatics Quantitative Pharmacology and Drug Disposition (QPD) Biopharma, Merck KGaA, 64293, Darmstadt, Germany., Morandi F; Discovery and Development Technologies, EMD Serono Research and Development Institute, Inc., Billerica, MA, 01821, USA., Ma J; Research Unit Oncology, EMD Serono Research and Development Institute, Inc., 45A Middlesex Turnpike, Billerica, MA, 01821, USA., Clark A; Research Unit Oncology, EMD Serono Research and Development Institute, Inc., 45A Middlesex Turnpike, Billerica, MA, 01821, USA.

Publikováno v: Scientific reports [Sci Rep] 2023 Nov 21; Vol. 13 (1), pp. 20412. Date of Electronic Publication: 2023 Nov 21.