The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.

Autor: Goodfellow HS; Howard Hughes Medical Institute, UCSF, San Francisco, CA 94143, USA.; Department of Medicine, UCSF, San Francisco, CA 94143, USA., Frushicheva MP; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Ji Q; Department of Chemistry, Brown University, Providence, RI 02912, USA., Cheng DA; Howard Hughes Medical Institute, UCSF, San Francisco, CA 94143, USA.; Department of Medicine, UCSF, San Francisco, CA 94143, USA., Kadlecek TA; Howard Hughes Medical Institute, UCSF, San Francisco, CA 94143, USA.; Department of Medicine, UCSF, San Francisco, CA 94143, USA., Cantor AJ; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA., Kuriyan J; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA.; Department of Chemistry, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Chakraborty AK; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Salomon A; Department of Chemistry, Brown University, Providence, RI 02912, USA.; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA., Weiss A; Howard Hughes Medical Institute, UCSF, San Francisco, CA 94143, USA.; Department of Medicine, UCSF, San Francisco, CA 94143, USA.

Publikováno v: Science signaling [Sci Signal] 2015 May 19; Vol. 8 (377), pp. ra49. Date of Electronic Publication: 2015 May 19.