Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration

Autor: Castillo-Azofeifa, David, Fazio, Elena N, Nattiv, Roy, Good, Hayley J, Wald, Tomas, Pest, Michael A, de Sauvage, Frederic J, Klein, Ophir D, Asfaha, Samuel

Publikováno v: The EMBO journal, vol 38, iss 4

During homeostasis, the colonic epithelium is replenished every 3-5days by rapidly cycling Lgr5+ stem cells. However, various insults can lead to depletion of Lgr5+ stem cells, and colonic epithelium can be regenerated from Lgr5-negative cells. While

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::f0cded372613f78d779a3e5541131042
https://escholarship.org/uc/item/09z9j5nh

Atoh1 ⁺ secretory progenitors possess renewal capacity independent of Lgr5 ⁺ cells during colonic regeneration.

Autor: Castillo-Azofeifa D; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, USA., Fazio EN; Department of Medicine, University of Western Ontario, London, ON, Canada., Nattiv R; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, USA.; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Good HJ; Department of Medicine, University of Western Ontario, London, ON, Canada., Wald T; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, USA., Pest MA; Department of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada., de Sauvage FJ; Department of Molecular Oncology, Genentech, South San Francisco, CA, USA., Klein OD; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, USA ophir.klein@ucsf.edu sasfaha2@uwo.ca.; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Asfaha S; Department of Medicine, University of Western Ontario, London, ON, Canada ophir.klein@ucsf.edu sasfaha2@uwo.ca.

Publikováno v: The EMBO journal [EMBO J] 2019 Feb 15; Vol. 38 (4). Date of Electronic Publication: 2019 Jan 11.