Safety and biological outcomes following a phase 1 trial of GD2-specific CAR-T cells in patients with GD2-positive metastatic melanoma and other solid cancers

Autor: Gonzalo Tapia Rico, Michael P Brown, Andrew Ruszkiewicz, Amy Johnson, Tessa Gargett, Nga T H Truong, Wenbo Yu, Erica C F Yeo, Nicole L Wittwer, Bryan Gardam, Jesikah Logan, Purany Sivaloganathan, Maria Collis

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)

Background Chimeric antigen receptor (CAR) T cell therapies specific for the CD19 and B-cell maturation antigen have become an approved standard of care worldwide for relapsed and refractory B-cell malignancies. If CAR-T cell therapy for non-hematolo

Externí odkaz: https://doaj.org/article/8e9e3a75af7840e99fd72a527e82ccbb

Plasma glycoproteomic biomarkers identify metastatic melanoma patients with reduced clinical benefit from immune checkpoint inhibitor therapy

Autor: Chad Pickering, Paul Aiyetan, Gege Xu, Alan Mitchell, Rachel Rice, Yana G. Najjar, Joseph Markowitz, Lisa M. Ebert, Michael P. Brown, Gonzalo Tapia-Rico, Dennie Frederick, Xin Cong, Daniel Serie, Klaus Lindpaintner, Flavio Schwarz, Genevieve M. Boland

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

The clinical success of immune-checkpoint inhibitors (ICI) in both resected and metastatic melanoma has confirmed the validity of therapeutic strategies that boost the immune system to counteract cancer. However, half of patients with metastatic dise

Externí odkaz: https://doaj.org/article/62cef259e9024020840ad1d244cbbd04

Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial

Autor: Yunda Huang, Giuseppe Pantaleo, Gonzalo Tapia, Brittany Sanchez, Lily Zhang, Monica Trondsen, Arnt-Ove Hovden, Richard Pollard, Jürgen Rockstroh, Mats Ökvist, Maja A. Sommerfelt

Publikováno v: EBioMedicine, Vol 24, Iss C, Pp 195-204 (2017)

Background: In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24Gag vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART) received six immunizations over 18 weeks, followed by analytical treatment in

Externí odkaz: https://doaj.org/article/fc8f494e48c9497d8de11cf5cf214668

Safety and immunogenicity of CD40.HIVRI.Env, a dendritic cell-based HIV vaccine, in healthy HIV-uninfected adults: a first-in-human randomized, placebo-controlled, dose-escalation study (ANRS VRI06)

Autor: Levy, Yves, Candotti, Fabio, Centlivre, Mireille, Desvallées, Mathilde, Diallo, Alpha, Durand, Mélany, Ding, Song, Hanot, Laurent, Hardel, Lucile, Hocini, Hakim, Lacabaratz, Christine, Lelièvre, Jean-Daniel, Levoyer, Léa, Moog, Christiane, Pantaleo, Giuseppe, Paul, Stéphane, Richert, Laura, Rieux, Véronique, Surgers, Laure, Wiedemann, Aurélie, Viard, Jean-Paul, Batteux, Frédéric, Grabar, Sophie, Pollard, Hélène, Lachatre, Marie, Mercier, Noémie, Molinari, Laura, Pinoges, Loretxu, Boston, Anaïs, Boilet, Valérie, Campion, Cécilia, Delahaye, Solenne, Dembélé, Mohamed, Guillochon, Quentin, Khalil, Youssra, Soutthiphong, Anne-Aygline, Taïeb, Ludivine, Wittkop, Linda, Thiebaut, Rodolphe, Foucat, Emile, Krief, Corinne, Ribeiro, Alexandre, Rodrigues, Cécile, Decoville, Thomas, Laumond, Géraldine, Li, Li-Yun, Schmidt, Sylvie, Fenwick, Craig, Gonzalo, Tapia, Kiehl, Philippe, Ben Rayana, Raida, Bouvier, Magali, Diombera, Harouna, Mehawej, Hanane, Verlinde-Carvalho, Muriel, Zatta, Marta, Launay, Odile, Tanah, Motolete Alaba, Cheref, Kahina, Durel-Maurisse, Aurélie, Favreau, Mathilde, Grange, Pascal, Guerin, Corinne, Luong, Liem Binh, Parfait, Béatrice, Christinet, Vanessa, Hottinger, Rosemary, Sommer, Isabelle, Tommasini, Francesco, Voidey, Aline, Salazar, Andres, Cardinaud, Sylvain, Zurawski, Sandra, Zurawski, Gerard, Tomaras, Georgia D.

Publikováno v: In eClinicalMedicine November 2024 77

An Extreme Learning Machine for Blood Pressure Waveform Estimation using the Photoplethysmography Signal

Autor: Gonzalo Tapia, Rodrigo Salas, Matías Salinas, Carolina Saavedra, Alejandro Veloz, Alexis Arriola, Steren Chabert, Antonio Glaría

Publikováno v: Journal of Engineering Research and Sciences. 1:161-174

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc644dbe5a36fa3c3ad8181a8d120f50
https://doi.org/10.55708/js0104018