Výsledky vyhledávání - "Gonzalo Raúl Acevedo"

Akademický článek

Different genotypes of Trypanosoma cruzi produce distinctive placental environment genetic response in chronic experimental infection.

Autor: Natalia Anahí Juiz, María Elisa Solana, Gonzalo Raúl Acevedo, Alejandro Francisco Benatar, Juan Carlos Ramirez, Priscilla Almeida da Costa, Andrea Mara Macedo, Silvia Andrea Longhi, Alejandro G Schijman

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005436 (2017)

Congenital infection of Trypanosoma cruzi allows transmission of this parasite through generations. Despite the problematic that this entails, little is known about the placenta environment genetic response produced against infection. We performed fu

Externí odkaz: https://doaj.org/article/93006ca35c8541dfbedcfb78bd366b53

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Akademický článek

Production of the main celiac disease autoantigen by transient expression in Nicotiana benthamiana

Autor: Vanesa Soledad Marin Viegas, Gonzalo Raúl Acevedo, Mariela Paula Bayardo, Fernando Gabriel Chirdo, Silvana ePetruccelli

Publikováno v: Frontiers in Plant Science, Vol 6 (2015)

Celiac Disease (CD) is a gluten sensitive enteropathy that remains widely undiagnosed and implementation of massive screening tests is needed to reduce the long term complications associated to untreated CD. The main CD autoantigen, human tissue tran

Externí odkaz: https://doaj.org/article/29781c9441374242bfe56d001e9d5535

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Genetic polymorphism of Trypanosoma cruzi bloodstream populations in adult chronic indeterminate Chagas disease patients from the E1224 clinical trial

Autor: Juan Carlos Ramírez, Gonzalo Raúl Acevedo, Carolina Torres, Rudy Parrado, Anabelle De La Barra, Sandro Villarroel, Lineth García, Joaquim Gascon, Lourdes Ortiz, Faustino Torrico, Isabela Ribeiro, Alejandro Gabriel Schijman

Publikováno v: J Antimicrob Chemother

Background The role that the genetic diversity of natural Trypanosoma cruzi populations plays in response to trypanocidal treatment of chronic Chagas disease (CD) patients remains to be understood. We analysed the genetic polymorphisms of parasite bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53435611138056501ac41879e32d9ea4
https://pubmed.ncbi.nlm.nih.gov/34865002

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T Cell Specificity: A Great Challenge in Chagas Disease

Autor: Karina A. Gómez, Fátima Ferragut, Gonzalo Raúl Acevedo

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
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Consejo Nacional de Investigaciones Científicas y Técnicas
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Frontiers in Immunology

The CD4+ and CD8+ T cell immune response against T. cruzi, the parasite causing Chagas disease, are relevant for both parasite control and disease pathogenesis. Several studies have been focused on their phenotype and functionally, but only a few hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e29477dca7e85d66404a497a5fb3370
https://www.frontiersin.org/articles/10.3389/fimmu.2021.674078/full

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IgE antibodies against Trypanosoma cruzi arginine kinase in patients with chronic Chagas disease

Autor: Vilma G. Duschak, Mariana R. Miranda, Fabio A Digirolamo, Juan Luis Concepción, Yolanda Hernández, Luciana Lía Soprano, Gonzalo Raúl Acevedo, Ana J. Cáceres, Karina A. Gómez, Edward A. Valera-Vera, Claudio A. Pereira, Marisa M. Fernández

Publikováno v: Molecular immunology. 138

Arginine kinase (AK) is an enzyme present in various invertebrates, as well as in some trypanosomatids such as T. cruzi, the etiological agent that causes Chagas disease. In invertebrates, this protein acts as an allergen inducing an IgE-type humoral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1f6ab64e976fe8a3e91c15f47699da
https://pubmed.ncbi.nlm.nih.gov/34364074

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In Silico Guided Discovery of Novel Class I and II Trypanosoma cruzi Epitopes Recognized by T Cells from Chagas’ Disease Patients

Autor: Marisa Liliana Fernandez, Lucas Perez Perri, Morten Nielsen, Natalia Anahí Juiz, Magalí C. Girard, Karina A. Gómez, Andrea Ziblat, Micaela S. Ossowski, Gonzalo Raúl Acevedo, Michael Wittig, Andre Franke, Yolanda Hernández, Raúl Chadi

T cell-mediated immune response plays a crucial role in controlling Trypanosoma cruzi infection and parasite burden, but it is also involved in the clinical onset and progression of chronic Chagas´ disease. Therefore, the study of T cells is central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de20b88a35aeb8e801da7f52acfec7d
https://www.jimmunol.org/content/204/6/1571

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CD4+ T cells from chronic Chagas disease patients with different degrees of cardiac compromise exhibit distinct expression patterns of inhibitory receptors TIGIT, Tim-3 and Lag-3

Autor: Magalí C. Girard, Karina A. Gómez, Marisa M. Fernández, Raúl Chadi, MP Beati, Gonzalo Raúl Acevedo, Yolanda Hernández, Alcaráz Pb

T cells are central to adaptive immune response against T. cruzi infection. In the chronic stage of Chagas disease, circulating parasite-specific memory T cells show reduced functionality and increased expression of inhibitory receptors, possibly as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aef0642fe1ab98a8d47f945fc986e5a
https://doi.org/10.1101/694729

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Altered frequency of CD24highCD38high transitional B cells in patients with cardiac involvement of chronic Chagas disease

Autor: Micaela S. Ossowski, Marisa M. Fernández, Gonzalo Raúl Acevedo, Raúl Chadi, Alcaráz Pb, Magalí C. Girard, Yolanda Hernández, Karina A. Gómez

The cardiomyopathy developed by patients with chronic Chagas disease (CCD), one of the most severe consequences of T. cruzi infection, is mainly associated with an imbalance between an excessive inflammatory reaction and a defective immunomodulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02b8604f53b51f23c89acbba70386ec

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Generation of T. cruzi-Specific Primary CD4+ T Cell Lines from Peripheral Blood Mononuclear Cells Isolated from Chagas Disease Patients

Autor: Paula B Alcaráz, Gonzalo Raúl Acevedo, Karina A. Gómez, Clemencia Pinilla

Publikováno v: T. cruzi infection
Methods in Molecular Biology ISBN: 9781493991471

Human CD8+ and CD4+ T cell lines and clones are valuable tools to explore the role of these cells in the context of diseases, especially in cases in which the main underlying actor is the immune response, like Chagas disease. These cell lines and clo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c13a82f05bf31bb0aa15b169de579b
https://link.springer.com/protocol/10.1007/978-1-4939-9148-8_24

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A panoramic view of the immune response to Trypanosoma cruzi infection

Autor: Gonzalo Raúl Acevedo, Karina A. Gómez, Magalí C. Girard

Publikováno v: Chagas disease: A clinical approach
Chagas Disease ISBN: 9783030000530

Chagas disease is a complex disorder in which the immunological response developed by the host plays a fundamental role, not only in the clearance of the parasite but also in the inflammatory status observed in specific affected tissues. Chagas disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672fe3155267b6daeb4cbd8439d779e7
https://link.springer.com/chapter/10.1007/978-3-030-00054-7_3

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