Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gonzalo León-Espinosa"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The axon initial segment (AIS) is a region of the neuron that is critical for action potential generation as well as for the regulation of neural activity. This specialized structure—characterized by the expression of different types of io
Externí odkaz:
https://doaj.org/article/9430df4a28ef443491f19755fb189cad
Publikováno v:
Frontiers in Neuroanatomy, Vol 16 (2022)
Hibernation in small mammals is a highly regulated process with periods of torpor involving drops in body temperature and metabolic rate, as well as a general decrease in neural activity, all of which proceed alongside complex brain adaptive changes
Externí odkaz:
https://doaj.org/article/29ec5922827e4968a98a62dde87aa50a
Publikováno v:
Frontiers in Neuroanatomy, Vol 13 (2019)
Hibernating mammals undergo torpor periods characterized by a general decrease in body temperature, metabolic rate, and brain activity accompanied by complex adaptive brain changes that appear to protect the brain from extreme conditions of hypoxia a
Externí odkaz:
https://doaj.org/article/be3390e0176d47f393e941f46e6b2375
Autor:
Jesús Avila, Gonzalo León-Espinosa, Esther García, Vega García-Escudero, Félix Hernández, Javier DeFelipe
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2012 (2012)
Almost a 20% of the residues of tau protein are phosphorylatable amino acids: serine, threonine, and tyrosine. In this paper we comment on the consequences for tau of being a phosphoprotein. We will focus on serine/threonine phosphorylation. It will
Externí odkaz:
https://doaj.org/article/8e8e63d3b63f4ad48844d67cc6a42159
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The axon initial segment (AIS) is a region of the neuron that is critical for action potential generation as well as for the regulation of neural activity. This specialized structure—characterized by the expression of different types of ion channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31186fa455f95e5c1265ad270451bd41
https://pubmed.ncbi.nlm.nih.gov/35610289
https://pubmed.ncbi.nlm.nih.gov/35610289
Autor:
Javier DeFelipe, Félix Hernández, Diana Furcila, Mamen Regalado-Reyes, Jesús Avila, Gonzalo León-Espinosa
Publikováno v:
Journal of Alzheimer's Disease
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
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Despite extensive studies regarding tau phosphorylation progression in both human Alzheimer's disease cases and animal models, the molecular and structural changes responsible for neurofibrillary tangle development are still not well understood. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bfbe812eb59684145c08d69d9649c0
http://europepmc.org/articles/PMC6598029
http://europepmc.org/articles/PMC6598029
Autor:
Mamen Regalado-Reyes, Javier DeFelipe, Gonzalo León-Espinosa, Isabel Fernaud-Espinosa, Ruth Benavides-Piccione
Publikováno v:
Cerebral Cortex Communications
The dendritic spines of pyramidal cells are the main postsynaptic target of excitatory glutamatergic synapses. Morphological alterations have been described in hippocampal dendritic spines during hibernation—a state of inactivity and metabolic depr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80d060554e8da487af768ae5d98d010
http://europepmc.org/articles/PMC8152943
http://europepmc.org/articles/PMC8152943
Autor:
Gonzalo León-Espinosa, Leyre Sanchez‐Rojas, M. Monleón Pradas, Juan A. Barcia, Cristina Lendinez, Fernando J. Rascón-Ramírez, María Soledad Benito-Martín, Cristina Martínez-Ramos, Jorge Matías-Guiu, Ulises Gómez-Pinedo
Publikováno v:
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
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Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
Endogenous neurogenesis in stroke is insufficient to replace the lost brain tissue, largely due to the lack of a proper biological structure to let new cells dwell in the damaged area. We hypothesized that scaffolds made of hyaluronic acid (HA) bioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4206f1a050a3c999ad34f8a27c6dd017
https://doi.org/10.1002/jbm.b.34252
https://doi.org/10.1002/jbm.b.34252
Autor:
Gonzalo León-Espinosa, Javier DeFelipe, Asta Kastanauskaite, Ricardo Insausti, Ruth Benavides-Piccione, Idan Segev, Concepción Rojo, Isabel Fernaud-Espinosa, Silvia Tapia-González, Mamen Regalado-Reyes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cerebral Cortex
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Cerebral Cortex
Pyramidal neurons are the most common cell type and are considered the main output neuron in most mammalian forebrain structures. In terms of function, differences in the structure of the dendrites of these neurons appear to be crucial in determining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e18e1d2aaf20855e0fa14dc34d6d8a0
http://hdl.handle.net/10261/217458
http://hdl.handle.net/10261/217458
Autor:
Coral Barbas, Javier DeFelipe, Antonia García, Mamen Regalado-Reyes, Carolina Gonzalez-Riano, Gonzalo León-Espinosa
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Syrian hamsters undergo a reversible hyperphosphorylation of protein t during hibernation, providing a unique natural model that may unveil the physiological mechanisms behind this critical process involved in the development of Alzheimer's disease a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ea3386628c027a6c63adce32548945
https://pubmed.ncbi.nlm.nih.gov/30623656
https://pubmed.ncbi.nlm.nih.gov/30623656