Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gonzalo I. Gómez"'
Autor:
Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz, Juan A. Orellana
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-19 (2024)
Abstract Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcoho
Externí odkaz:
https://doaj.org/article/f80f0199ed6744449b3c85991d733a5d
Autor:
Gonzalo I. Gómez, Claudia García-Rodríguez, Jesús E. Marillán, Sergio A. Vergara, Tanhia F. Alvear, Arantza Farias-Pasten, Juan C. Sáez, Mauricio A. Retamal, Maximiliano Rovegno, Fernando C. Ortiz, Juan A. Orellana
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Multiple studies have demonstrated that acute ethanol consumption alters brain function and cognition. Nevertheless, the mechanisms underlying this phenomenon remain poorly understood. Astrocyte-mediated gliotransmission is crucial for hippocampal pl
Externí odkaz:
https://doaj.org/article/463f97fa14b444faa3d5873fc85c37d1
Autor:
Claudia M. Lucero, Laura Navarro, Cristián Barros-Osorio, Patricio Cáceres-Conejeros, Juan A. Orellana, Gonzalo I. Gómez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Chronic kidney disease (CKD) is a prevalent health concern associated with various pathological conditions, including hypertensive nephropathy. Mesangial cells are crucial in maintaining glomerular function, yet their involvement in CKD pathogenesis
Externí odkaz:
https://doaj.org/article/e4c68d29d50c4fca9a92c2095aea4f94
Autor:
Juan Prieto-Villalobos, Claudia M. Lucero, Maximiliano Rovegno, Gonzalo I. Gómez, Mauricio A. Retamal, Juan A. Orellana
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-14 (2023)
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infe
Externí odkaz:
https://doaj.org/article/5207d3d0de97481f8147092d77a85606
Autor:
Claudia M. Lucero, Juan Prieto-Villalobos, Lucas Marambio-Ruiz, Javiera Balmazabal, Tanhia F. Alvear, Matías Vega, Paola Barra, Mauricio A. Retamal, Juan A. Orellana, Gonzalo I. Gómez
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15936 (2022)
Hypertension is one of the most common risk factors for developing chronic cardiovascular diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes damage and activation of mesangial cells (MCs), eliciting the productio
Externí odkaz:
https://doaj.org/article/cfd1ce8b30824c71b1822e61ded0707a
Autor:
Claudia M. Lucero, Lucas Marambio-Ruiz, Javiera Balmazabal, Juan Prieto-Villalobos, Marcelo León, Paola Fernández, Juan A. Orellana, Victoria Velarde, Juan C. Sáez, Gonzalo I. Gómez
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10097 (2022)
Connexin 43 (Cx43) is expressed in kidney tissue where it forms hemichannels and gap junction channels. However, the possible functional relationship between these membrane channels and their role in damaged renal cells remains unknown. Here, analysi
Externí odkaz:
https://doaj.org/article/9808bb4a8d1c4acca66f7a5355f731a9
Autor:
Juan Prieto-Villalobos, Tanhia F. Alvear, Andrés Liberona, Claudia M. Lucero, Claudio J. Martínez-Araya, Javiera Balmazabal, Carla A. Inostroza, Gigliola Ramírez, Gonzalo I. Gómez, Juan A. Orellana
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9503 (2021)
Maternal inflammation during pregnancy causes later-in-life alterations of the offspring’s brain structure and function. These abnormalities increase the risk of developing several psychiatric and neurological disorders, including schizophrenia, in
Externí odkaz:
https://doaj.org/article/527f748093034109a5f74dd62326b830
Autor:
Gonzalo I. Gómez, Romina V. Falcon, Carola J. Maturana, Valeria C. Labra, Nicole Salgado, Consuelo A. Rojas, Juan E. Oyarzun, Waldo Cerpa, Rodrigo A. Quintanilla, Juan A. Orellana
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
A mounting body of evidence indicates that adolescents are specially more susceptible to alcohol influence than adults. However, the mechanisms underlying this phenomenon remain poorly understood. Astrocyte-mediated gliotransmission is crucial for hi
Externí odkaz:
https://doaj.org/article/4300ac1bc8854dfabe1467bfed1d39c1
Autor:
Rosario Gajardo-Gómez, Cristian A. Santibañez, Valeria C. Labra, Gonzalo I. Gómez, Eliseo A. Eugenin, Juan A. Orellana
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2503 (2020)
At least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive, behavioral and motor deficits, collectively known as HIV-associated neurocognitive disorders (HAND). The molecular mechanisms that amplify
Externí odkaz:
https://doaj.org/article/abe4dbe843374ec6857e3f30d54caf5d
Autor:
Juan C. Sáez, Susana Contreras-Duarte, Gonzalo I. Gómez, Valeria C. Labra, Cristian A. Santibañez, Rosario Gajardo-Gómez, Beatriz C. Avendaño, Esteban F. Díaz, Trinidad D. Montero, Victoria Velarde, Juan A. Orellana
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction. We used EAhy 926 cells treat
Externí odkaz:
https://doaj.org/article/1e4f03d8525a4bd293b2ee61e30ff826