Zobrazeno 1 - 10
of 673
pro vyhledávání: '"Gonzalo I"'
Publikováno v:
RNA Biology, Vol 16, Iss 12, Pp 1775-1784 (2024)
Pre-messenger RNA splicing involves multi-step assembly of the large spliceosome complexes that catalyse the two consecutive trans-esterification reactions, resulting in intron removal. There is evidence that proof-reading mechanisms monitor the fide
Externí odkaz:
https://doaj.org/article/fe41cc9df50f45d7853c0dfdf966cbe4
Autor:
Bastián I. Cortés, Rodrigo C. Meza, Carlos Ancatén-González, Nicolás M. Ardiles, María-Ignacia Aránguiz, Hideaki Tomita, David R. Kaplan, Francisca Cornejo, Alexia Nunez-Parra, Pablo R. Moya, Andrés E. Chávez, Gonzalo I. Cancino
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-15 (2024)
Abstract Background The brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have long-lasting consequences on brain function and are associated with the etiology of brain disorders. We previo
Externí odkaz:
https://doaj.org/article/d4a3502f9ed749f19ffeddc6183b865b
Autor:
Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz, Juan A. Orellana
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-19 (2024)
Abstract Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcoho
Externí odkaz:
https://doaj.org/article/f80f0199ed6744449b3c85991d733a5d
Autor:
Gonzalo I. Gómez, Claudia García-Rodríguez, Jesús E. Marillán, Sergio A. Vergara, Tanhia F. Alvear, Arantza Farias-Pasten, Juan C. Sáez, Mauricio A. Retamal, Maximiliano Rovegno, Fernando C. Ortiz, Juan A. Orellana
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Multiple studies have demonstrated that acute ethanol consumption alters brain function and cognition. Nevertheless, the mechanisms underlying this phenomenon remain poorly understood. Astrocyte-mediated gliotransmission is crucial for hippocampal pl
Externí odkaz:
https://doaj.org/article/463f97fa14b444faa3d5873fc85c37d1
Autor:
América Chandía-Cristi, Daniela A. Gutiérrez, Andrés E. Dulcey, Marcelo Lara, Lina Vargas, Yi-Han Lin, Pablo Jimenez-Muñoz, Gabriela Larenas, Xin Xu, Amy Wang, Ashley Owens, Christopher Dextras, YuChi Chen, Claudio Pinto, Tamara Marín, Hugo Almarza-Salazar, Keryma Acevedo, Gonzalo I. Cancino, Xin Hu, Patricio Rojas, Marc Ferrer, Noel Southall, Mark J. Henderson, Silvana Zanlungo, Juan J. Marugan, Alejandra Álvarez R
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114144- (2024)
Summary: The molecular mechanisms underlying seizure generation remain elusive, yet they are crucial for developing effective treatments for epilepsy. The current study shows that inhibiting c-Abl tyrosine kinase prevents apoptosis, reduces dendritic
Externí odkaz:
https://doaj.org/article/d6f3af7f5f984ae686e586e3fd0a0393
Autor:
Claudia M. Lucero, Laura Navarro, Cristián Barros-Osorio, Patricio Cáceres-Conejeros, Juan A. Orellana, Gonzalo I. Gómez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Chronic kidney disease (CKD) is a prevalent health concern associated with various pathological conditions, including hypertensive nephropathy. Mesangial cells are crucial in maintaining glomerular function, yet their involvement in CKD pathogenesis
Externí odkaz:
https://doaj.org/article/e4c68d29d50c4fca9a92c2095aea4f94
Autor:
Juan Prieto-Villalobos, Claudia M. Lucero, Maximiliano Rovegno, Gonzalo I. Gómez, Mauricio A. Retamal, Juan A. Orellana
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-14 (2023)
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infe
Externí odkaz:
https://doaj.org/article/5207d3d0de97481f8147092d77a85606
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Neurodevelopmental disorders are characterized by alterations in the development of the cerebral cortex, including aberrant changes in the number and function of neural cells. Although neurogenesis is one of the most studied cellular processes in the
Externí odkaz:
https://doaj.org/article/f5881abd171146b8b06f93671c6a3d76
Autor:
Tamara Marín, Cristian Valls, Carolina Jerez, Tomás Huerta, Daniela Elgueta, René L. Vidal, Alejandra R. Alvarez, Gonzalo I. Cancino
Publikováno v:
IBRO Neuroscience Reports, Vol 13, Iss , Pp 378-387 (2022)
Parkinson's disease is the second most common neurodegenerative disorder. Although it is clear that dopaminergic neurons degenerate, the underlying molecular mechanisms are still unknown, and thus, successful treatment is still elusive. One pro-apopt
Externí odkaz:
https://doaj.org/article/c775d2a7ef1a4dfdb42297089a619ce0
Autor:
Rilda León, Daniela A. Gutiérrez, Claudio Pinto, Cristian Morales, Catalina de la Fuente, Cristóbal Riquelme, Bastián I. Cortés, Adrián González-Martin, David Chamorro, Nelson Espinosa, Pablo Fuentealba, Gonzalo I. Cancino, Silvana Zanlungo, Andrés E. Dulcey, Juan J. Marugan, Alejandra Álvarez Rojas
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundGrowing evidence suggests that the non-receptor tyrosine kinase, c-Abl, plays a significant role in the pathogenesis of Alzheimer’s disease (AD). Here, we analyzed the effect of c-Abl on the cognitive performance decline of APPSwe/PSEN1Δ
Externí odkaz:
https://doaj.org/article/6accec4f1b6445c78136a93af6f6172c