Výsledky vyhledávání - "Gonzalo, Rodríguez Berriguete"

Homeostasis: apoptosis and cell cycle in normal and pathological prostate

Autor: Raúl Vera, Manuel Sánchez-Chapado, Ricardo Paniagua, Benito Fraile, Norelia Torrealba, Gonzalo Rodríguez-Berriguete, Pilar Martínez-Onsurbe, Mar Royuela, Gabriel Olmedilla

Publikováno v: The aging male : the official journal of the International Society for the Study of the Aging Male. 23(5)

Prostatic diseases such as hyperplasia and cancer are a consequence of glandular aging due to the loss of homeostasis. Glandular homeostasis is guaranteed by the delicate balance between production and cell death. Both cell renewal and apoptosis are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919d783060b065916c886090cd68b97e
https://pubmed.ncbi.nlm.nih.gov/29730957

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PI3K pathway and Bcl-2 family. Clinicopathological features in prostate cancer

Autor: Mar Royuela, Gonzalo Rodríguez-Berriguete, Manuel Sánchez-Chapado, Benito Fraile, Ricardo Paniagua, Gabriel Olmedilla, Norelia Torrealba, Pilar Martínez-Onsurbe

Publikováno v: The aging male : the official journal of the International Society for the Study of the Aging Male. 21(3)

The phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathways and Bcl-2 family play a central role in prostate cancer (PC). The aim was to determine influence in the biochemical progression in PC. To evaluate the association between clinic pathological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4561853194fdb724bb278135f375c2f4
https://pubmed.ncbi.nlm.nih.gov/29316844

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Epidermal growth factor induces p38 MAPK-dependent G0/G1-to-S transition in prostate cancer cells upon androgen deprivation conditions

Autor: Benito Fraile, Mar Royuela, Norelia Torrealba, Ricardo Paniagua, Gonzalo Rodríguez-Berriguete

Publikováno v: Growth factors (Chur, Switzerland). 34(1-2)

Epidermal growth factor (EGF) is thought to contribute to the emergence of castration-resistant (CR) prostate tumors by inducing proliferation of cancer cells despite the low levels of circulating androgens achieved by androgen deprivation therapy. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c4d27be994c6f08fda72e5161af530
https://pubmed.ncbi.nlm.nih.gov/26880218

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Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors

Autor: Gabriel Olmedilla, Gonzalo Rodríguez-Berriguete, F R Bethencourt, Pilar Martínez-Onsurbe, Benito Fraile, Laura Galvis, Ricardo Paniagua, Mar Royuela

Publikováno v: Human Pathology. 43:229-237

Summary Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4390278da4a161395afa92b30316802a
https://doi.org/10.1016/j.humpath.2011.04.024

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Expression of NF-κB-related proteins and their modulation during TNF-α-provoked apoptosis in prostate cancer cells

Autor: Benito Fraile, Gonzalo Rodríguez-Berriguete, Patricio Aller, Ricardo Paniagua, Mar Royuela

Publikováno v: The Prostate. 72:40-50

BACKGROUND The involvement of TNF-α in cancer development is controversial, since this cytokine was reported to act either as tumor promoter or suppressor. TNF-α may activate signaling pathways critical for life/death decisions, such as mitogen-act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57ed9555691fa513f1254c1499bc5987
https://doi.org/10.1002/pros.21404

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Pro-inflammatory cytokines and prostate-specific antigen in hyperplasia and human prostate cancer

Autor: Nawfel Ben Rais, Benito Fraile, Mónica Ricote, Ridha Oueslati, Ricardo Paniagua, Mar Royuela, Yosra Bouraoui, Ignacio García-Tuñón, Gonzalo Rodríguez-Berriguete, Mounir Touffehi

Publikováno v: Cancer Detection and Prevention. 32:23-32

Background : The aim of this study was to relate the expression, analyzed by Western blot and immunohistochemistry, of several pro-inflammatory cytokines, including IL-1, IL-6 and TNF-α, with serum levels of prostate-specific antigen (PSA) in normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b3335f7c78c986c3c42f6189cc3acd
https://doi.org/10.1016/j.cdp.2008.02.007

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Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

Autor: Manuel Guil-Cid, Norelia Torrealba, Benito Fraile, Pilar Martínez-Onsurbe, Gabriel Olmedilla, Miguel A Ortega, Mar Royuela, Gonzalo Rodríguez-Berriguete, Ricardo Paniagua

Publikováno v: e_Buah Biblioteca Digital Universidad de Alcalá
instname
BMC Cancer
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Background: The expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We explored the associations be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305f6389d9677e14df847a7710c5fa52
http://hdl.handle.net/10017/32720

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Clinical significance of both tumor and stromal expression of components of the IL-1 and TNF-α signaling pathways in prostate cancer

Autor: Pilar Martínez-Onsurbe, Benito Fraile, Beatriz Sanchez-Espiridion, Mar Royuela, Manuel Sánchez-Chapado, José R. Cansino, Gonzalo Rodríguez-Berriguete, Ricardo Paniagua, Gabriel Olmedilla

Publikováno v: Cytokine. 64(2)

IL-1 and TNF-α, the two major proinflammatory cytokines, have been involved in initiation and progression of several malignancies. They could influence the biological behavior of prostatic tumors and patient outcome, and could be useful as prognosti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceefdb3dcb42dcbf65666231f066e21f
https://pubmed.ncbi.nlm.nih.gov/24063999

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MAP Kinases and Prostate Cancer

Autor: Mar Royuela, Benito Fraile, Gabriel Olmedilla, Pilar Martínez-Onsurbe, Ricardo Paniagua, Gonzalo Rodríguez-Berriguete

Publikováno v: Journal of Signal Transduction

The three major mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK are signal transducers involved in a broad range of cell functions including survival, apoptosis, and cell differentiation. Whereas JNK and p38 have been generally linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8d56bbb5d47ffef0e198361ff290f3
https://pubmed.ncbi.nlm.nih.gov/22046506

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