Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial

Autor: Hildur Arnardottir, Sven-Christian Pawelzik, Ulf Öhlund Wistbacka, Gonzalo Artiach, Robin Hofmann, Ingalill Reinholdsson, Frieder Braunschweig, Per Tornvall, Dorota Religa, Magnus Bäck

Publikováno v: Frontiers in Physiology, Vol 11 (2021)

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 triggers an immune response with local inflammation in the lung, which may extend to a systemic hyperinflammatory react

Externí odkaz: https://doaj.org/article/5b3a8175eda043468839ae9202f81f17

Proteoglycan 4 is Increased in Human Calcified Aortic Valves and Enhances Valvular Interstitial Cell Calcification

Autor: Gonzalo Artiach, Miguel Carracedo, Till Seime, Oscar Plunde, Andres Laguna-Fernandez, Ljubica Matic, Anders Franco-Cereceda, Magnus Bäck

Publikováno v: Cells, Vol 9, Iss 3, p 684 (2020)

Aortic valve stenosis (AVS), a consequence of increased fibrosis and calcification of the aortic valve leaflets, causes progressive narrowing of the aortic valve. Proteoglycans, structural components of the aortic valve, accumulate in regions with fi

Externí odkaz: https://doaj.org/article/91029a4bb91e4f62b6f906ae82b0168d

Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis

Autor: Hildur Arnardottir, Peter Sjövall, Miguel Carracedo, Oscar Plunde, Silke Thul, Magnus Bäck, Gonzalo Artiach, Anders Franco-Cereceda, Craig E. Wheelock, Andres Laguna-Fernandez

Publikováno v: Circulation

Supplemental Digital Content is available in the text.
Background: Aortic valve stenosis (AVS), which is the most common valvular heart disease, causes a progressive narrowing of the aortic valve as a consequence of thickening and calcification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e4270d61f0ab97a60a398aec8df01c
https://doi.org/10.1161/circulationaha.119.041868

The resolvin D1 receptor GPR32 transduces inflammation-resolution and atheroprotection

Autor: Hildur Arnardottir, Göran K. Hansson, Gabrielle Paulsson-Berne, Gonzalo Artiach, Glykeria Karadimou, Miguel Carracedo, V. Mysdotter, April S. Caravaca, Sven-Christian Pawelzik, Roland Baumgartner, Silke Thul, Peder S. Olofsson, Daniel F. J. Ketelhuth, Magnus Bäck, Laura Tarnawski

Publikováno v: Arnardottir, H, Thul, S, Karadimou, G, Pawelzik, S-C, Artiach, G, Mysdotter, V, Carracedo, M, Tarnawski, L, Caravaca, A S, Baumgartner, R, Ketelhuth, D F, Olofsson, P S, Paulsson-Berne, G, Hansson, G K & Back, M 2021, ' The resolvin D1 receptor GPR32 transduces inflammation-resolution and atheroprotection ', Atherosclerosis, vol. 331, pp. E9 . https://doi.org/10.1016/j.atherosclerosis.2021.06.032

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b77ba7bfce861f3863fc11099b9f9f0
https://portal.findresearcher.sdu.dk/da/publications/f9e60f1c-522b-4984-991c-5006a38fe395

The resolution of inflammation through omega-3 fatty acids in atherosclerosis, intimal hyperplasia, and vascular calcification

Autor: Magnus Bäck, Gonzalo Artiach, Hildur Arnardottir, Miguel Carracedo

Publikováno v: Seminars in Immunopathology

Omega-3 fatty acids serve as the substrate for the formation of a group of lipid mediators that mediate the resolution of inflammation. The cardiovascular inflammatory response in atherosclerosis and vascular injury is characterized by a failure in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9634798742ee4be9320e5a82c101e63d
http://europepmc.org/articles/PMC6881483