Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection.

Autor: Martin GM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Pholcharee T; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Department of Biochemistry, University of Oxford, Oxford, OX1 3DR, UK., Oyen D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Pfizer Inc, San Diego, CA, 92121, USA., Flores-Garcia Y; Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Gibson G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Moskovitz R; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Jung DD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Copps J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Gonzalez-Paez G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Emerling D; Atreca Inc, San Carlos, CA, 94070, USA., MacGill RS; PATH's Malaria Vaccine Initiative, Washington, DC, 20001, USA., Locke E; PATH's Malaria Vaccine Initiative, Washington, DC, 20001, USA., King CR; PATH's Malaria Vaccine Initiative, Washington, DC, 20001, USA., Zavala F; Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. andrew@scripps.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 28; Vol. 14 (1), pp. 4546. Date of Electronic Publication: 2023 Jul 28.

Comparative analyses of functional antibody-mediated inhibition with anti-circumsporozoite monoclonal antibodies against transgenic Plasmodium berghei.

Autor: Nicholas, Justin^1,2 (AUTHOR), Kolli, Surendra Kumar¹ (AUTHOR), Subramani, Pradeep Annamalai¹ (AUTHOR), De, Sai Lata^1,3 (AUTHOR), Ogbondah, Madison M.¹ (AUTHOR), Barnes, Samantha J.¹ (AUTHOR), Ntumngia, Francis Babila¹ (AUTHOR), Adams, John H.¹ (AUTHOR) ja2@usf.edu

Publikováno v: Malaria Journal. 11/7/2023, Vol. 22 Issue 1, p1-10. 10p.

Progress in vaccine development for infectious diseases—a Keystone Symposia report.

Autor: Cable, Jennifer¹ (AUTHOR) annals@nyas.org, Graham, Barney S.² (AUTHOR), Koup, Richard A.³ (AUTHOR), Seder, Robert A.³ (AUTHOR), Karikó, Katalin⁴ (AUTHOR), Pardi, Norbert⁵ (AUTHOR), Barouch, Dan H.⁶ (AUTHOR), Sharma, Bhawna⁷ (AUTHOR), Rauch, Susanne⁸ (AUTHOR), Nachbagauer, Raffael^9,10 (AUTHOR), Forsell, Mattias N. E.¹¹ (AUTHOR), Schotsaert, Michael^9,12 (AUTHOR), Ellebedy, Ali H.¹³ (AUTHOR), Loré, Karin¹⁴ (AUTHOR), Irvine, Darrell J.^15,16,17 (AUTHOR), Pilkington, Emily^18,19 (AUTHOR), Tahtinen, Siri²⁰ (AUTHOR), Thompson, Elizabeth A.²¹ (AUTHOR), Feraoun, Yanis²² (AUTHOR), King, Neil P.²³ (AUTHOR)

Publikováno v: Annals of the New York Academy of Sciences. Jun2023, Vol. 1524 Issue 1, p65-86. 22p. 2 Diagrams.

A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.

Autor: Beutler, Nathan¹ (AUTHOR), Pholcharee, Tossapol² (AUTHOR), Oyen, David² (AUTHOR), Flores-Garcia, Yevel³ (AUTHOR), MacGill, Randall S.⁴ (AUTHOR), Garcia, Elijah¹ (AUTHOR), Calla, Jaeson⁵ (AUTHOR), Parren, Mara¹ (AUTHOR), Yang, Linlin¹ (AUTHOR), Volkmuth, Wayne⁶ (AUTHOR), Locke, Emily⁴ (AUTHOR), Regules, Jason A.⁷ (AUTHOR), Dutta, Sheetij⁷ (AUTHOR), Emerling, Daniel⁶ (AUTHOR), Early, Angela M.^8,9 (AUTHOR), Neafsey, Daniel E.^8,9 (AUTHOR), Winzeler, Elizabeth⁵ (AUTHOR), King, C. Richter⁴ (AUTHOR), Zavala, Fidel³ (AUTHOR), Burton, Dennis R.^1,10 (AUTHOR) burton@scripps.edu

Publikováno v: PLoS Pathogens. 3/28/2022, Vol. 18 Issue 3, p1-21. 21p.

Novel antibody competition binding assay identifies distinct serological profiles associated with protection.

Autor: Bolton, Jessica S., MacGill, Randall S., Locke, Emily, Regules, Jason A., Bergmann-Leitner, Elke S.

Publikováno v: Frontiers in Immunology; 2023, p1-10, 10p