The universal suppressor mutation restores membrane budding defects in the HSV-1 nuclear egress complex by stabilizing the oligomeric lattice.

Autor: Draganova EB; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America., Wang H; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America.; Department of Bioengineering, UCLA, Los Angeles, California, United States of America.; California NanoSystems Institute, UCLA, Los Angeles, California, United States of America., Wu M; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia., Liao S; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America.; California NanoSystems Institute, UCLA, Los Angeles, California, United States of America., Vu A; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America., Gonzalez-Del Pino GL; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America., Zhou ZH; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America.; Department of Bioengineering, UCLA, Los Angeles, California, United States of America.; California NanoSystems Institute, UCLA, Los Angeles, California, United States of America., Roller RJ; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America., Heldwein EE; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2024 Jan 16; Vol. 20 (1), pp. e1011936. Date of Electronic Publication: 2024 Jan 16 (Print Publication: 2024).

Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.

Autor: Gonzalez-Del Pino GL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Li K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Park E; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Schmoker AM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Ha BH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215; eck@crystal.harvard.edu.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 07; Vol. 118 (36).