Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response.

Autor: Pagadala M; Biomedical Sciences Program, University of California San Diego, La Jolla, CA, 92093, USA., Sears TJ; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, 92093, USA., Wu VH; Department of Pharmacology, UCSD Moores Cancer Center, La Jolla, CA, 92093, USA., Pérez-Guijarro E; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Kim H; Undergraduate Bioengineering Program, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, 92093, USA., Castro A; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, 92093, USA., Talwar JV; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, 92093, USA., Gonzalez-Colin C; La Jolla Institute for Immunology, La Jolla, CA, 92037, USA., Cao S; Division of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA., Schmiedel BJ; La Jolla Institute for Immunology, La Jolla, CA, 92037, USA., Goudarzi S; Canyon Crest Academy, San Diego, CA, 92130, USA., Kirani D; Undergraduate Biology and Bioinformatics Program, University of California San Diego, La Jolla, CA, 92093, USA., Au J; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, 92093, USA., Zhang T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Landi T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Salem RM; Division of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA., Morris GP; Department of Pathology, University of California San Diego, La Jolla, CA, 92093, USA., Harismendy O; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, 92093, USA.; Division of Biomedical Informatics, Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, 92093, USA., Patel SP; Center for Personalized Cancer Therapy, Division of Hematology and Oncology, UC San Diego Moores Cancer Center, San Diego, CA, 92037, USA., Alexandrov LB; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA., Mesirov JP; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA, 92093, USA., Zanetti M; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA.; The Laboratory of Immunology and Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Day CP; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Fan CC; Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK, 74136, USA.; Department of Radiology, University of California San Diego, La Jolla, CA, 92093, USA., Thompson WK; Division of Biostatistics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA., Merlino G; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Gutkind JS; Department of Pharmacology, UCSD Moores Cancer Center, La Jolla, CA, 92093, USA., Vijayanand P; La Jolla Institute for Immunology, La Jolla, CA, 92037, USA., Carter H; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA. hkcarter@health.ucsd.edu.; Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA, 92093, USA. hkcarter@health.ucsd.edu.

Publikováno v: Nature communications [Nat Commun] 2023 May 12; Vol. 14 (1), pp. 2744. Date of Electronic Publication: 2023 May 12.

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.

Autor: Schmiedel BJ; La Jolla Institute for Immunology, La Jolla, CA, USA., Rocha J; La Jolla Institute for Immunology, La Jolla, CA, USA.; Center for Genomic Sciences, National Autonomous University of Mexico, Cuernavaca, Morelos, Mexico., Gonzalez-Colin C; La Jolla Institute for Immunology, La Jolla, CA, USA.; Center for Genomic Sciences, National Autonomous University of Mexico, Cuernavaca, Morelos, Mexico., Bhattacharyya S; La Jolla Institute for Immunology, La Jolla, CA, USA., Madrigal A; La Jolla Institute for Immunology, La Jolla, CA, USA., Ottensmeier CH; La Jolla Institute for Immunology, La Jolla, CA, USA.; Liverpool Head and Neck Centre, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Ay F; La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Chandra V; La Jolla Institute for Immunology, La Jolla, CA, USA., Vijayanand P; La Jolla Institute for Immunology, La Jolla, CA, USA. vijay@lji.org.; Liverpool Head and Neck Centre, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. vijay@lji.org.; Department of Medicine, University of California San Diego, La Jolla, CA, USA. vijay@lji.org.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 19; Vol. 12 (1), pp. 6760. Date of Electronic Publication: 2021 Nov 19.

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.

Autor: Schmiedel BJ; La Jolla Institute for Immunology, La Jolla, CA, USA.; Equally contributed to this work., Chandra V; La Jolla Institute for Immunology, La Jolla, CA, USA.; Equally contributed to this work., Rocha J; La Jolla Institute for Immunology, La Jolla, CA, USA.; Equally contributed to this work., Gonzalez-Colin C; La Jolla Institute for Immunology, La Jolla, CA, USA.; Equally contributed to this work., Bhattacharyya S; La Jolla Institute for Immunology, La Jolla, CA, USA., Madrigal A; La Jolla Institute for Immunology, La Jolla, CA, USA., Ottensmeier CH; La Jolla Institute for Immunology, La Jolla, CA, USA.; Liverpool Head and Neck Centre, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, UK., Ay F; La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Joint senior authors., Vijayanand P; La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Liverpool Head and Neck Centre, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, UK.; Joint senior authors.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Dec 02. Date of Electronic Publication: 2020 Dec 02.

Effects of Akt Activator SC79 on Human M0 Macrophage Phagocytosis and Cytokine Production.

Autor: Lee, Robert J.^1,2 (AUTHOR) nithin.adappa@pennmedicine.upenn.edu, Adappa, Nithin D.¹ (AUTHOR) james.palmer@pennmedicine.upenn.edu, Palmer, James N.¹ (AUTHOR)

Publikováno v: Cells (2073-4409). Jun2024, Vol. 13 Issue 11, p902. 21p.

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