GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis

Autor: Shahi, P, Wang, C-Y, Chou, J, Hagerling, C, Gonzalez Velozo, H, Ruderisch, A, Yu, Y, Lai, M-D, Werb, Z

Publikováno v: Oncogene, vol 36, iss 40

Semaphorin 3B (SEMA3B) is a secreted axonal guidance molecule that is expressed during development and throughout adulthood. Recently, SEMA3B has emerged as a tumor suppressor in non-neuronal cells. Here, we show that SEMA3B is a direct target of GAT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::37a2df75339f0b4d40fbf171fae7008c
https://escholarship.org/uc/item/2xz6p07t

Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases.

Autor: Christensson G; Department of Experimental Medical Science, Lund University, Lund, Sweden.; Lund University Cancer Centre (LUCC), Lund University, Lund, Sweden., Bocci M; Lund University Cancer Centre (LUCC), Lund University, Lund, Sweden.; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden., Kazi JU; Lund University Cancer Centre (LUCC), Lund University, Lund, Sweden.; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden., Durand G; Lund University Cancer Centre (LUCC), Lund University, Lund, Sweden.; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Lanzing G; Department of Experimental Medical Science, Lund University, Lund, Sweden.; Lund University Cancer Centre (LUCC), Lund University, Lund, Sweden., Pietras K; Lund University Cancer Centre (LUCC), Lund University, Lund, Sweden.; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden., Gonzalez Velozo H; Department of Anatomy, University of California, San Francisco, San Francisco, California.; Laboratory of Tumor Microenvironment and Metastasis, Centro Ciencia & Vida, Santiago, Chile., Hagerling C; Department of Experimental Medical Science, Lund University, Lund, Sweden.; Lund University Cancer Centre (LUCC), Lund University, Lund, Sweden.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Nov 01; Vol. 4 (11), pp. 2888-2902.

ZNF50 3/ Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression.

Autor: Shahi P; Department of Anatomy and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143., Wang CY; Department of Anatomy and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143., Lawson DA; Department of Anatomy and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143., Slorach EM; Department of Anatomy and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143., Lu A; Department of Anatomy and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143., Yu Y; Department of Anatomy and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143., Lai MD; Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan., Gonzalez Velozo H; Department of Anatomy and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143., Werb Z; Department of Anatomy and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143; zena.werb@ucsf.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Mar 21; Vol. 114 (12), pp. 3169-3174. Date of Electronic Publication: 2017 Mar 03.