Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function.

Autor: Andrade AF; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada.; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada., Annett A; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Karimi E; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada., Topouza DG; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Rezanejad M; Departments of Psychology and Computer Science, University of Toronto, Toronto, ON, M5S 3G3, M5S 2E4, Canada., Liu Y; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada., McNicholas M; Department of Oncology and The Milner Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; CRUK Children's Brain Tumour Centre of Excellence, University of Cambridge, Cambridge, E20 1JQ, UK., Gonzalez Santiago EG; Department of Pediatrics, Yale School of Medicine, New Haven, CT, 06510, USA., Llivichuzhca-Loja D; Department of Pediatrics, Yale School of Medicine, New Haven, CT, 06510, USA., Gehlhaar A; Life and Medical Sciences Institute, University of Bonn, Bonn, 53115, Germany., Jessa S; Quantitative Life Sciences, McGill University, Montreal, QC, Canada.; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, H3T 1E2, Canada., De Cola A; Department of Oncology and The Milner Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; CRUK Children's Brain Tumour Centre of Excellence, University of Cambridge, Cambridge, E20 1JQ, UK., Chandarana B; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Russo C; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Faury D; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Danieau G; Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Division of Orthopedic Surgery, McGill University Health Centre, Montreal, QC, H4A 3J1, Canada., Puligandla E; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Wei Y; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada., Zeinieh M; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Wu Q; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Hebert S; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada.; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, H3T 1E2, Canada., Juretic N; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Nakada EM; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Krug B; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Larouche V; Department of Pediatrics, Centre mère-enfant Soleil du CHU de Québec-Université Laval, Quebec City, QC, G1V 4G2, Canada., Weil AG; Brain and Development Research Axis, Sainte-Justine Research Centre, Montreal, QC, H3T 1C5, Canada.; Division of Neurosurgery, Department of Surgery, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, QC, H3T 1C5, Canada.; Department of Neuroscience, University of Montreal, Montreal, QC, H2X 0A9, Canada., Dudley RWR; Department of Pediatric Surgery, Division of Neurosurgery, Montreal Children's Hospital, McGill University, Montreal, QC, H4A 3J1, Canada., Karamchandani J; Department of Pathology, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Agnihotri S; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA., Quail DF; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, QC, H3G 1Y6, Canada.; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC, H4A 3J1, Canada., Ellezam B; Division of Pathology, Department of Pathology and Cell Biology, CHU Sainte-Justine, Université de Montréal, Montreal, QC, H3T 1C5, Canada., Konnikova L; Department of Pediatrics, Yale School of Medicine, New Haven, CT, 06510, USA. liza.konnikova@yale.edu.; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, 06510, USA. liza.konnikova@yale.edu.; Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT, 06510, USA. liza.konnikova@yale.edu., Walsh LA; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada.; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada., Pathania M; Department of Oncology and The Milner Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK. mp915@cam.ac.uk.; CRUK Children's Brain Tumour Centre of Excellence, University of Cambridge, Cambridge, E20 1JQ, UK. mp915@cam.ac.uk., Kleinman CL; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada. claudia.kleinman@mcgill.ca.; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, H3T 1E2, Canada. claudia.kleinman@mcgill.ca., Jabado N; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada. nada.jabado@mcgill.ca.; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada. nada.jabado@mcgill.ca.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada. nada.jabado@mcgill.ca.; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC, H4A 3J1, Canada. nada.jabado@mcgill.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 05; Vol. 15 (1), pp. 7769. Date of Electronic Publication: 2024 Sep 05.