Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.

Autor: Tonnus W; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany., Meyer C; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany., Steinebach C; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, Bonn, Germany., Belavgeni A; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany., von Mässenhausen A; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany., Gonzalez NZ; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany., Maremonti F; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany., Gembardt F; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany., Himmerkus N; Institute of Physiology, Christian-Albrecht-University Kiel, Kiel, Germany., Latk M; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany., Locke S; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany., Marschner J; Division of Nephrology, Department of Medicine IV, University Hospital LMU Munich, Munich, Germany., Li W; Department of Surgery, Washington University, Saint Louis, MO, USA., Short S; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada., Doll S; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Ingold I; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Proneth B; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Daniel C; Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany., Kabgani N; Clinic for Renal and Hypertensive Disorders, Rheumatological and Immunological Disease, University Hospital of the RWTH Aachen, Aachen, Germany., Kramann R; Clinic for Renal and Hypertensive Disorders, Rheumatological and Immunological Disease, University Hospital of the RWTH Aachen, Aachen, Germany.; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands., Motika S; Department of Pathobiology, University of Illinois, Urbana, IL, USA., Hergenrother PJ; Department of Pathobiology, University of Illinois, Urbana, IL, USA., Bornstein SR; Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Diabetes and Nutritional Sciences, King's College London, London, UK.; Center for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden Faculty of Medicine, Dresden, Germany.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore City, Singapore., Hugo C; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany., Becker JU; Institute of Pathology, University Hospital of Cologne, Cologne, Germany., Amann K; Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany., Anders HJ; Division of Nephrology, Department of Medicine IV, University Hospital LMU Munich, Munich, Germany., Kreisel D; Department of Surgery, Washington University, Saint Louis, MO, USA.; Department of Pathology and Immunology, Washington University, Saint Louis, MO, USA., Pratt D; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada., Gütschow M; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, Bonn, Germany., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.; National Research Medical University, Laboratory of Experimental Oncology, Moscow, Russia., Linkermann A; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany. andreas.linkermann@ukdd.de.; Biotechnology Center, Technische Universität Dresden, Dresden, Germany. andreas.linkermann@ukdd.de.

Publikováno v: Nature communications [Nat Commun] 2021 Jul 20; Vol. 12 (1), pp. 4402. Date of Electronic Publication: 2021 Jul 20.