Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake.

Autor: Romero-Picó A; Instituto de Salud Carlos III, CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Department of Physiology, CIMUS - University of Santiago de Compostela, Santiago de Compostela 15782 Spain. Electronic address: amparo.romero@usc.es., Sanchez-Rebordelo E; Department of Physiology, CIMUS - University of Santiago de Compostela, Santiago de Compostela 15782 Spain., Imbernon M; Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Center, INSERM, U1172, University of Lille, France., González-Touceda D; Department of Physiology, CIMUS - University of Santiago de Compostela, Santiago de Compostela 15782 Spain., Folgueira C; Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Spain., Senra A; Department of Physiology, CIMUS - University of Santiago de Compostela, Santiago de Compostela 15782 Spain., Fernø J; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Norway., Blouet C; MRC Metabolic Disease Unit, Institute of Metabolic Science, University of Cambridge, UK., Cabrera R; Department of Experimental and Health Science, Universitat Pompeu Fabra, Barcelona Spain., van Gestel M; Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands., Adan RA; Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands., López M; Instituto de Salud Carlos III, CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Department of Physiology, CIMUS - University of Santiago de Compostela, Santiago de Compostela 15782 Spain; Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Spain., Maldonado R; Department of Experimental and Health Science, Universitat Pompeu Fabra, Barcelona Spain., Nogueiras R; Instituto de Salud Carlos III, CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Department of Physiology, CIMUS - University of Santiago de Compostela, Santiago de Compostela 15782 Spain; Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es., Diéguez C; Instituto de Salud Carlos III, CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Department of Physiology, CIMUS - University of Santiago de Compostela, Santiago de Compostela 15782 Spain; Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Spain.

Publikováno v: Neuropharmacology [Neuropharmacology] 2018 Mar 01; Vol. 130, pp. 62-70. Date of Electronic Publication: 2017 Dec 02.

Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice.

Autor: Pazos P; Department of Physiology/Research Center of Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad (MINECO), Spain., Lima L; Department of Physiology/Research Center of Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Tovar S; Department of Physiology/Research Center of Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad (MINECO), Spain., González-Touceda D; Department of Physiology/Research Center of Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad (MINECO), Spain., Diéguez C; Department of Physiology/Research Center of Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad (MINECO), Spain., García MC; Department of Physiology/Research Center of Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad (MINECO), Spain.

Publikováno v: Scientific reports [Sci Rep] 2015 Dec 10; Vol. 5, pp. 17977. Date of Electronic Publication: 2015 Dec 10.

Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.

Autor: Lear PV; Department of Physiology (P.V.L., D.G.-T., B.P.C., R.N., C.D.), Centre for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela and Institute of Health Sciences, and Department of Morphological Sciences (P.V., T.G.-C.), School of Medicine and University Clinical Hospital, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; Department of Pharmacology (P.V.L., R.T., P.W.T., J.P.), Oxford University, Oxford OX1 3QT, United Kingdom; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (D.G.-T., B.P.C., R.N., C.D.), 15706, Santiago de Compostela, Spain; Department of Physiology, Anatomy, and Genetics (V.G., H.C.C.), Oxford University, Oxford OX1 3QX, United Kingdom; and Neurometabolic Unit (E.R., A.C., I.P.H.), National Hospital for Neurology and Neurosurgery, University College London Hospitals, Queen Square, London WC1N 3BG, United Kingdom., González-Touceda D, Porteiro Couto B, Viaño P, Guymer V, Remzova E, Tunn R, Chalasani A, García-Caballero T, Hargreaves IP, Tynan PW, Christian HC, Nogueiras R, Parrington J, Diéguez C

Publikováno v: Endocrinology [Endocrinology] 2015 Mar; Vol. 156 (3), pp. 975-86. Date of Electronic Publication: 2014 Dec 29.

Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.

Autor: Romero-Picó A; Department of Physiology, School of Medicine-CIMUS-Instituto de Investigaciones Sanitarias (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), San Francisco s/n, Santiago de Compostela (A Coruña), University of Santiago de Compostela, Santiago de Compostela, Spain., Vázquez MJ, González-Touceda D, Folgueira C, Skibicka KP, Alvarez-Crespo M, Van Gestel MA, Velásquez DA, Schwarzer C, Herzog H, López M, Adan RA, Dickson SL, Diéguez C, Nogueiras R

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2013 Jun; Vol. 38 (7), pp. 1296-307. Date of Electronic Publication: 2013 Jan 24.

The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depressive-like Behaviors.

Autor: van de Wetering, Ross¹ (AUTHOR), Ewald, Amy¹ (AUTHOR), Welsh, Susan¹ (AUTHOR), Kornberger, Lindsay² (AUTHOR) prisinzano@uky.edu, Williamson, Samuel E.³ (AUTHOR), McElroy, Bryan D.⁴ (AUTHOR), Butelman, Eduardo R.⁴ (AUTHOR), Prisinzano, Thomas E.^2,3 (AUTHOR), Kivell, Bronwyn M.¹ (AUTHOR) bronwyn.kivell@vuw.ac.nz

Publikováno v: Molecules. Jun2023, Vol. 28 Issue 12, p4848. 22p.