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Autor:
Serrano-Ríos Manuel, Real Luis M, Gayán Javier, Martínez-Larrad María T, González-Pérez Antonio, Sáez María E, Ruiz Agustín
Publikováno v:
BMC Medical Genetics, Vol 11, Iss 1, p 148 (2010)
Abstract Background Altered lipid profile, and in particular low HDL and high triglyceride (TG) plasma levels, are within the major determinants of cardiovascular diseases. The identification of quantitative trait loci (QTL) affecting these lipid lev
Externí odkaz:
https://doaj.org/article/beb5636d9b2d4ca0aa34f4e81412b8da
'Does replication groups scoring reduce false positive rate in SNP interaction discovery?: Response'
Publikováno v:
BMC Genomics, Vol 11, Iss 1, p 403 (2010)
Abstract A response to Toplak et al: Does replication groups scoring reduce false positive rate in SNP interaction discovery? BMC Genomics 2010, 11:58. Background The genomewide evaluation of genetic epistasis is a computationally demanding task, and
Externí odkaz:
https://doaj.org/article/9d72deb40eb842e392efa01c055c4b56
Autor:
Gutiérrez Marta, Ochoa María, Molero Eva, Ochoa Carolina, Carrasco José M, Velasco Juan, Moreno-Rey Concha, Royo Jose, Morón Francisco J, Ramírez-Lorca Reposo, Salinas Ana, Rivero M Carmen, Zabena Carina, Martínez-Larrad María, Sáez María, González-Pérez Antonio, Galan José J, Gayán Javier, Reina Mercedes, Pascual Rocío, Romo-Astorga Alejandro, Susillo-González Juan, Vázquez Enrique, Real Luis M, Ruiz Agustín, Serrano-Ríos Manuel
Publikováno v:
BMC Genomics, Vol 11, Iss 1, p 326 (2010)
Abstract Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results In this stud
Externí odkaz:
https://doaj.org/article/8a4f75e18c0e4531af7058fcaeb69ed3
Autor:
González-Pérez Antonio, Romo-Astorga Alejandro, Susillo-González Juan, Cordoba José, Matilla-García Mariano, Ruiz-Marín Manuel, Ruiz Agustín, Gayán Javier
Publikováno v:
BMC Genetics, Vol 11, Iss 1, p 19 (2010)
Abstract Background The etiology of complex diseases is due to the combination of genetic and environmental factors, usually many of them, and each with a small effect. The identification of these small-effect contributing factors is still a demandin
Externí odkaz:
https://doaj.org/article/d45c9637dec1448584922d250ec14539
Autor:
Ruiz Agustín, Serrano-Hernando Javier, González-Pérez Antonio, Martínez-Larrad María T, Manzano Luis, Morón Francisco J, Grilo Antonio, Sáez María E, Ramírez-Lorca Reposo, Serrano-Ríos Manuel
Publikováno v:
Cardiovascular Diabetology, Vol 7, Iss 1, p 23 (2008)
Abstract Context Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed. Objective To investigate the possibility of the existence of a cro
Externí odkaz:
https://doaj.org/article/9e1b3695aad54135a8043f8adfd9f1e4
Autor:
Galan Jose, Quintas Antonio, Royo Jose, Sáez María, Bermudo Fernando, González-Pérez Antonio, Gayán Javier, Morón Francisco, Ramirez-Lorca Reposo, Real Luis, Ruiz Agustín
Publikováno v:
BMC Genomics, Vol 9, Iss 1, p 360 (2008)
Abstract Background The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease. Some of these genetic effects may interact in complex ways, proving undetectable by curren
Externí odkaz:
https://doaj.org/article/73fd3d434c064522b28bb5b9f39a1f3e
Publikováno v:
BMC Medicine, Vol 3, Iss 1, p 17 (2005)
Abstract Background Recent data indicate that chronic use of coxibs leads to an increased occurrence of thrombotic cardiovascular events. This raises the question as to whether traditional non-steroidal anti-inflammatory drugs (tNSAIDs) might also pr
Externí odkaz:
https://doaj.org/article/0def4ee1e5b04c0d91bcbd5fcba509ac
Publikováno v:
BMC Cancer, Vol 3, Iss 1, p 28 (2003)
Abstract Background Observational studies have consistently shown that aspirin and non-steroidal anti-inflammatory drug (NSAID) use is associated with a close to 50% reduced risk of colorectal cancer. Studies assessing the effects of NSAIDs on other
Externí odkaz:
https://doaj.org/article/80d1917455cd4fd5a32f19b88782185b