Výsledky vyhledávání - "González Soto, K. E."

Specific and safe targeting of glioblastoma using switchable and logic-gated RevCAR T cells

Autor: Abdelfatah Saleh Hassan, H. A., Mitwasi, N., Ullrich, M., Kubeil, M., Toussaint, M., Deuther-Conrad, W., Neuber, C., Arndt, C., Rodrigues Loureiro, L. R., Kegler, A., González Soto, K. E., Belter, B., Rössig, C., Pietzsch, J., Frenz, M., Bachmann, M., Feldmann, A.

Publikováno v: Frontiers in Immunology 14(2023), 1166169

Glioblastoma (GBM) is still an incurable tumor that is associated with high recurrence rate and poor survival despite the current treatment regimes. With the urgent need for novel therapeutic strategies, immunotherapies, especially chimeric antigen r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7b7e198045e8de2c36b95ca509d5ba
https://doi.org/10.3389/fimmu.2023.1166169

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A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells

Publikováno v: Frontiers in Immunology 14(2023), 1204543

The COVID-19 pandemic caused by SARS-CoV-2 led to millions of infections and deaths worldwide. As this virus evolves rapidly, there is a high need for treatment options, which can win the race against new emerging variants of concern. Here, we descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::fdce3d0afa5c96d96efc48a7e94d2f77
https://www.hzdr.de/publications/Publ-37085-1

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As small as it can be: short peptide-derived target molecules for redirection of UniCAR T-cells and imaging of SSTR2-expressing cancers

Autor: Loureiro, L. R., Bergmann, R., Wodtke, R., Brandt, F., Arndt, C., González Soto, K. E., Mitwasi, N., Kegler, A., Bartsch, T., Drewitz, L., Máthé, D., Feldmann, A., Bachmann, M.

Publikováno v: International Conference on Lymphocyte Engineering: ICLE 2022, 31.03.2022, Munich, Germany

Chimeric antigen receptor (CAR) T-cells are undoubtedly a promising approach in cancer immunotherapy. Nevertheless, mild to severe toxicities are associated with this approach including on-target/off-tumor effects and cytokine release syndrome. Aimin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::82ee679d55efbb300cac99b2e78b78d4
https://www.hzdr.de/publications/Publ-33876-1

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Adapter CARs: Estimation of the affinity between adapter and CAR domain required for function

Autor: Bartsch, T., Arndt, C., González Soto, K. E., Wodtke, R., Brandt, F., Loureiro, L. R., Mitwasi, N., Kegler, A., Feldmann, A., Bachmann, M.

Publikováno v: TUMOR IMMUNOLOGY MEETS ONCOLOGY (TIMO) XVI 2022 HALLE, 07.-09.07.2022, Halle, Deutschland

As next generation for CAR T cells, adaptor CAR platforms have been developed, which are designed to improve safety, but at the same time maintain the high efficiency of the CAR T cell approach. In our lab, we developed the UniCAR system, which consi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::7de400d0e45c769deb9eb2040bc3f571
https://www.hzdr.de/publications/Publ-35749-1

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RevCAR platform as a combinatorial approach for targeting acute myeloid leukemia

Autor: Loureiro, L. R., González Soto, K. E., Kittel-Boselli, E., Hoffmann, A., Bergmann, R., Arndt, C., Mitwasi, N., Kegler, A., Bartsch, T., Berndt, N., Altmann, H., Fasslrinner, F., Bornhäuser, M., Bachmann, M., Feldmann, A.

Publikováno v: World Immunotherapy Council´s 4th Young Investigator Symposium (WIC), 10.11.2021, Washington, USA

Background: In the past years, the treatment of acute myeloid leukemia (AML) has been significantly shifted towards the development of targeted approaches. Nonetheless, clinical translation of novel immunotherapeutic strategies such as chimeric antig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::7ea2641bfc6e4d6ff82374c6a6b25c89
https://www.hzdr.de/publications/Publ-33377-1

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Development of novel α-CEA target modules (RevTMs) for the switchable RevCAR system

Autor: González Soto, K. E.

Publikováno v: HZDR, 2019

Cancer is one of the main causes of death and represents a worldwide health problem. Most of the cancer-related deaths are associated with the appearance and progression of a solid tumor. Even though effective conventional treatments exist, they shar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::07b01cae74b6807f28ab8c880617fba2
https://www.hzdr.de/publications/Publ-30213-1

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